Electrospun Biodegradable Nanofibers Coated Homogenously by Cu
Magnetron Sputtering Exhibit Fast Ion Release. Computational
and Experimental Study

J 2021

Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study

MANAKHOV, Anton M.; Natalya A. SITNIKOVA; Alphiya R. TSYGANKOVA; Alexander Yu. ALEKSEEV; Lyubov S. ADAMENKO et. al.

Základní údaje

Originální název

Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study

Autoři

MANAKHOV, Anton M. (garant); Natalya A. SITNIKOVA; Alphiya R. TSYGANKOVA; Alexander Yu. ALEKSEEV; Lyubov S. ADAMENKO; Elizaveta PERMYAKOVA; Victor S. BAIDYSHEV; Zakhar I. POPOV; Lucie BLAHOVÁ; Marek ELIÁŠ; Lenka ZAJÍČKOVÁ (203 Česká republika, domácí) a Anastasiya O. SOLOVIEVA

Vydání

Membranes, Basel, MDPI, 2021, 2077-0375

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20506 Coating and films

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.562

Kód RIV

RIV/00216224:14310/21:00123872

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/membranes11120965

UT WoS

000735924500001

EID Scopus

2-s2.0-85121317279

Klíčová slova anglicky

PCL nanofibers; XPS; copper; antibacterial coating; ion release; cytotoxicity

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 2. 2023 19:05, doc. Mgr. Lenka Zajíčková, Ph.D.

Anotace

V originále

Copper-coated nanofibrous materials are desirable for catalysis, electrochemistry, sensing, and biomedical use. The preparation of copper or copper-coated nanofibers can be pretty challenging, requiring many chemical steps that we eliminated in our robust approach, where for the first time, Cu was deposited by magnetron sputtering onto temperature-sensitive polymer nanofibers. For the first time, the large-scale modeling of PCL films irradiation by molecular dynamics simulation was performed and allowed to predict the ions penetration depth and tune the deposition conditions. The Cu-coated polycaprolactone (PCL) nanofibers were thoroughly characterized and tested as antibacterial agents for various Gram-positive and Gram-negative bacteria. Fast release of Cu2+ ions (concentration up to 3.4 mu g/mL) led to significant suppression of E. coli and S. aureus colonies but was insufficient against S. typhimurium and Ps. aeruginosa. The effect of Cu layer oxidation upon contact with liquid media was investigated by X-ray photoelectron spectroscopy revealing that, after two hours, 55% of Cu atoms are in form of CuO or Cu(OH)(2). The Cu-coated nanofibers will be great candidates for wound dressings thanks to an interesting synergistic effect: on the one hand, the rapid release of copper ions kills bacteria, while on the other hand, it stimulates the regeneration with the activation of immune cells. Indeed, copper ions are necessary for the bacteriostatic action of cells of the immune system. The reactive CO2/C2H4 plasma polymers deposited onto PCL-Cu nanofibers can be applied to grafting of viable proteins, peptides, or drugs, and it further explores the versatility of developed nanofibers for biomedical applications use.

Citovat

MANAKHOV, Anton M.; Natalya A. SITNIKOVA; Alphiya R. TSYGANKOVA; Alexander Yu. ALEKSEEV; Lyubov S. ADAMENKO; Elizaveta PERMYAKOVA; Victor S. BAIDYSHEV; Zakhar I. POPOV; Lucie BLAHOVÁ; Marek ELIÁŠ; Lenka ZAJÍČKOVÁ a Anastasiya O. SOLOVIEVA. Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study. Membranes. Basel: MDPI, 2021, roč. 11, č. 12, s. 965-983. ISSN 2077-0375. Dostupné z: https://dx.doi.org/10.3390/membranes11120965.

@article{1824593,
   author = {Manakhov, Anton M. and Sitnikova, Natalya A. and Tsygankova, Alphiya R. and Alekseev, Alexander Yu. and Adamenko, Lyubov S. and Permyakova, Elizaveta and Baidyshev, Victor S. and Popov, Zakhar I. and Blahová, Lucie and Eliáš, Marek and Zajíčková, Lenka and Solovieva, Anastasiya O.},
   article_location = {Basel},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/membranes11120965},
   keywords = {PCL nanofibers; XPS; copper; antibacterial coating; ion release; cytotoxicity},
   language = {eng},
   issn = {2077-0375},
   journal = {Membranes},
   title = {Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study},
   url = {https://www.mdpi.com/2077-0375/11/12/965},
   volume = {11},
   year = {2021}
}

TY  - JOUR
ID  - 1824593
AU  - Manakhov, Anton M. - Sitnikova, Natalya A. - Tsygankova, Alphiya R. - Alekseev, Alexander Yu. - Adamenko, Lyubov S. - Permyakova, Elizaveta - Baidyshev, Victor S. - Popov, Zakhar I. - Blahová, Lucie - Eliáš, Marek - Zajíčková, Lenka - Solovieva, Anastasiya O.
PY  - 2021
TI  - Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study
JF  - Membranes
VL  - 11
IS  - 12
SP  - 965
EP  - 965
PB  - MDPI
SN  - 20770375
KW  - PCL nanofibers
KW  - XPS
KW  - copper
KW  - antibacterial coating
KW  - ion release
KW  - cytotoxicity
UR  - https://www.mdpi.com/2077-0375/11/12/965
N2  - Copper-coated nanofibrous materials are desirable for catalysis, electrochemistry, sensing, and biomedical use. The preparation of copper or copper-coated nanofibers can be pretty challenging, requiring many chemical steps that we eliminated in our robust approach, where for the first time, Cu was deposited by magnetron sputtering onto temperature-sensitive polymer nanofibers. For the first time, the large-scale modeling of PCL films irradiation by molecular dynamics simulation was performed and allowed to predict the ions penetration depth and tune the deposition conditions. The Cu-coated polycaprolactone (PCL) nanofibers were thoroughly characterized and tested as antibacterial agents for various Gram-positive and Gram-negative bacteria. Fast release of Cu2+ ions (concentration up to 3.4 mu g/mL) led to significant suppression of E. coli and S. aureus colonies but was insufficient against S. typhimurium and Ps. aeruginosa. The effect of Cu layer oxidation upon contact with liquid media was investigated by X-ray photoelectron spectroscopy revealing that, after two hours, 55% of Cu atoms are in form of CuO or Cu(OH)(2). The Cu-coated nanofibers will be great candidates for wound dressings thanks to an interesting synergistic effect: on the one hand, the rapid release of copper ions kills bacteria, while on the other hand, it stimulates the regeneration with the activation of immune cells. Indeed, copper ions are necessary for the bacteriostatic action of cells of the immune system. The reactive CO2/C2H4 plasma polymers deposited onto PCL-Cu nanofibers can be applied to grafting of viable proteins, peptides, or drugs, and it further explores the versatility of developed nanofibers for biomedical applications use.
ER  -

MANAKHOV, Anton M.; Natalya A. SITNIKOVA; Alphiya R. TSYGANKOVA; Alexander Yu. ALEKSEEV; Lyubov S. ADAMENKO; Elizaveta PERMYAKOVA; Victor S. BAIDYSHEV; Zakhar I. POPOV; Lucie BLAHOVÁ; Marek ELIÁŠ; Lenka ZAJÍČKOVÁ a Anastasiya O. SOLOVIEVA. Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study. \textit{Membranes}. Basel: MDPI, 2021, roč.~11, č.~12, s.~965-983. ISSN~2077-0375. Dostupné z: https://dx.doi.org/10.3390/membranes11120965.

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