Low levels of minimal residual disease after induction
chemotherapy for BCR-ABL1-negative acute lymphoblastic
leukaemia in adults are clinically relevant

J 2022

Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant

SALEK, Cyril; František FOLBER; Eva FRONKOVA; Pavla PECHERKOVA; Hana JELINKOVA et al.

Základní údaje

Originální název

Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant

Autoři

SALEK, Cyril; František FOLBER; Eva FRONKOVA; Pavla PECHERKOVA; Hana JELINKOVA; Štěpán HRABOVSKÝ; Jan M. HORACEK; Petr CETKOVSKY; Jiří MAYER; Jan TRKA a Michael DOUBEK

Vydání

British journal of haematology, England, Wiley-Blackwell, 2022, 0007-1048

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.500

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/22:00125210

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

acute lymphoblastic leukaemia; minimal residual disease; prognostic factors; PCR; IG; TR rearrangements

Štítky

14110212, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 2. 2022 11:14, Mgr. Tereza Miškechová

Anotace

V originále

The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74 center dot 0%, 42 center dot 3% and 35 center dot 0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0 center dot 32 and 2 center dot 25).

Citovat

SALEK, Cyril; František FOLBER; Eva FRONKOVA; Pavla PECHERKOVA; Hana JELINKOVA; Štěpán HRABOVSKÝ; Jan M. HORACEK; Petr CETKOVSKY; Jiří MAYER; Jan TRKA a Michael DOUBEK. Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant. British journal of haematology. England: Wiley-Blackwell, 2022, roč. 196, č. 3, s. 706-710. ISSN 0007-1048. Dostupné z: https://doi.org/10.1111/bjh.17966.

@article{1824604,
   author = {Salek, Cyril and Folber, František and Fronkova, Eva and Pecherkova, Pavla and Jelinkova, Hana and Hrabovský, Štěpán and Horacek, Jan M. and Cetkovsky, Petr and Mayer, Jiří and Trka, Jan and Doubek, Michael},
   article_location = {England},
   article_number = {3},
   doi = {https://doi.org/10.1111/bjh.17966},
   keywords = {acute lymphoblastic leukaemia; minimal residual disease; prognostic factors; PCR; IG; TR rearrangements},
   language = {eng},
   issn = {0007-1048},
   journal = {British journal of haematology},
   title = {Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/bjh.17966},
   volume = {196},
   year = {2022}
}

TY  - JOUR
ID  - 1824604
AU  - Salek, Cyril - Folber, František - Fronkova, Eva - Pecherkova, Pavla - Jelinkova, Hana - Hrabovský, Štěpán - Horacek, Jan M. - Cetkovsky, Petr - Mayer, Jiří - Trka, Jan - Doubek, Michael
PY  - 2022
TI  - Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant
JF  - British journal of haematology
VL  - 196
IS  - 3
SP  - 706-710
EP  - 706-710
PB  - Wiley-Blackwell
SN  - 00071048
KW  - acute lymphoblastic leukaemia
KW  - minimal residual disease
KW  - prognostic factors
KW  - PCR
KW  - IG
KW  - TR rearrangements
UR  - https://onlinelibrary.wiley.com/doi/10.1111/bjh.17966
N2  - The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74 center dot 0%, 42 center dot 3% and 35 center dot 0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0 center dot 32 and 2 center dot 25).
ER  -

SALEK, Cyril; František FOLBER; Eva FRONKOVA; Pavla PECHERKOVA; Hana JELINKOVA; Štěpán HRABOVSKÝ; Jan M. HORACEK; Petr CETKOVSKY; Jiří MAYER; Jan TRKA a Michael DOUBEK. Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant. \textit{British journal of haematology}. England: Wiley-Blackwell, 2022, roč.~196, č.~3, s.~706-710. ISSN~0007-1048. Dostupné z: https://doi.org/10.1111/bjh.17966.

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