Pharyngeal Microbial Signatures Are Predictive of the Risk of
Fungal Pneumonia in Hematologic Patients

J 2021

Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients

COSTANTINI, Claudio; Emilia NUNZI; Angelica SPOLZINO; Melissa PALMIERI; Giorgia RENGA et al.

Základní údaje

Originální název

Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients

Autoři

Vydání

INFECTION AND IMMUNITY, WASHINGTON, The American Society for Microbiology, 2021, 0019-9567

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.616

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00119613

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

hematological malignancies; airway microbiome; antibiotics; indole-3-aldehyde; invasive fungal infection; metabolomics; tryptophan

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 6. 2025 13:54, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated. Nasal and oropharyngeal swabs were collected for functional microbiota characterization in 173 patients with hematological malignancies recruited in a multicenter, prospective, observational study and stratified according to the risk of developing IFI. A lower microbial richness and evenness were found in the pharyngeal microbiota of high-risk patients that were associated with a distinct taxonomic and metabolic profile. A murine model of IFI provided biologic plausibility for the finding that loss of protective anaerobes, such as Clostridiales and Bacteroidetes, along with an apparent restricted availability of tryptophan, is causally linked to the risk of IFI in hematologic patients and indicates avenues for antimicrobial stewardship and metabolic reequilibrium in IFI.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

GJ17-24592Y, projekt VaV

Název: Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

Investor: Grantová agentura ČR, Mapování interakcí mezi základními metabolickými pochody a střevní mikroflórou

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90051, velká výzkumná infrastruktura

Název: RECETOX II

Citovat

COSTANTINI, Claudio; Emilia NUNZI; Angelica SPOLZINO; Melissa PALMIERI; Giorgia RENGA; Teresa ZELANTE; Lukas ENGLMAIER; Kateřina COUFALÍKOVÁ; Zdeněk SPÁČIL; Monica BORGHI; Marina M. BELLET; Enzo ACERBI; Matteo PUCCETTI; Stefano GIOVAGNOLI; Roberta SPACCAPELO; Vincenzo N. TALESA; Giuseppe LOMURNO; Francesco MERLI; Luca FACCHINI; Antonio SPADEA; Lorella MELILLO; Katia CODELUPPI; Francesco MARCHESI; Gessica MARCHESINI; Daniela VALENTE; Giulia DRAGONETTI; Gianpaolo NADALI; Livio PAGANO; Franco AVERSA a Luigina ROMANI. Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients. INFECTION AND IMMUNITY. WASHINGTON: The American Society for Microbiology, 2021, roč. 89, č. 8, s. 1-17. ISSN 0019-9567. Dostupné z: https://doi.org/10.1128/IAI.00105-21.

@article{1826639,
   author = {Costantini, Claudio and Nunzi, Emilia and Spolzino, Angelica and Palmieri, Melissa and Renga, Giorgia and Zelante, Teresa and Englmaier, Lukas and Coufalíková, Kateřina and Spáčil, Zdeněk and Borghi, Monica and Bellet, Marina M. and Acerbi, Enzo and Puccetti, Matteo and Giovagnoli, Stefano and Spaccapelo, Roberta and Talesa, Vincenzo N. and Lomurno, Giuseppe and Merli, Francesco and Facchini, Luca and Spadea, Antonio and Melillo, Lorella and Codeluppi, Katia and Marchesi, Francesco and Marchesini, Gessica and Valente, Daniela and Dragonetti, Giulia and Nadali, Gianpaolo and Pagano, Livio and Aversa, Franco and Romani, Luigina},
   article_location = {WASHINGTON},
   article_number = {8},
   doi = {https://doi.org/10.1128/IAI.00105-21},
   keywords = {hematological malignancies; airway microbiome; antibiotics; indole-3-aldehyde; invasive fungal infection; metabolomics; tryptophan},
   language = {eng},
   issn = {0019-9567},
   journal = {INFECTION AND IMMUNITY},
   title = {Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients},
   url = {https://journals.asm.org/doi/10.1128/IAI.00105-21},
   volume = {89},
   year = {2021}
}

TY  - JOUR
ID  - 1826639
AU  - Costantini, Claudio - Nunzi, Emilia - Spolzino, Angelica - Palmieri, Melissa - Renga, Giorgia - Zelante, Teresa - Englmaier, Lukas - Coufalíková, Kateřina - Spáčil, Zdeněk - Borghi, Monica - Bellet, Marina M. - Acerbi, Enzo - Puccetti, Matteo - Giovagnoli, Stefano - Spaccapelo, Roberta - Talesa, Vincenzo N. - Lomurno, Giuseppe - Merli, Francesco - Facchini, Luca - Spadea, Antonio - Melillo, Lorella - Codeluppi, Katia - Marchesi, Francesco - Marchesini, Gessica - Valente, Daniela - Dragonetti, Giulia - Nadali, Gianpaolo - Pagano, Livio - Aversa, Franco - Romani, Luigina
PY  - 2021
TI  - Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients
JF  - INFECTION AND IMMUNITY
VL  - 89
IS  - 8
SP  - 1-17
EP  - 1-17
PB  - The American Society for Microbiology
SN  - 00199567
KW  - hematological malignancies
KW  - airway microbiome
KW  - antibiotics
KW  - indole-3-aldehyde
KW  - invasive fungal infection
KW  - metabolomics
KW  - tryptophan
UR  - https://journals.asm.org/doi/10.1128/IAI.00105-21
N2  - The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated. Nasal and oropharyngeal swabs were collected for functional microbiota characterization in 173 patients with hematological malignancies recruited in a multicenter, prospective, observational study and stratified according to the risk of developing IFI. A lower microbial richness and evenness were found in the pharyngeal microbiota of high-risk patients that were associated with a distinct taxonomic and metabolic profile. A murine model of IFI provided biologic plausibility for the finding that loss of protective anaerobes, such as Clostridiales and Bacteroidetes, along with an apparent restricted availability of tryptophan, is causally linked to the risk of IFI in hematologic patients and indicates avenues for antimicrobial stewardship and metabolic reequilibrium in IFI.
ER  -

COSTANTINI, Claudio; Emilia NUNZI; Angelica SPOLZINO; Melissa PALMIERI; Giorgia RENGA; Teresa ZELANTE; Lukas ENGLMAIER; Kateřina COUFALÍKOVÁ; Zdeněk SPÁČIL; Monica BORGHI; Marina M. BELLET; Enzo ACERBI; Matteo PUCCETTI; Stefano GIOVAGNOLI; Roberta SPACCAPELO; Vincenzo N. TALESA; Giuseppe LOMURNO; Francesco MERLI; Luca FACCHINI; Antonio SPADEA; Lorella MELILLO; Katia CODELUPPI; Francesco MARCHESI; Gessica MARCHESINI; Daniela VALENTE; Giulia DRAGONETTI; Gianpaolo NADALI; Livio PAGANO; Franco AVERSA a Luigina ROMANI. Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients. \textit{INFECTION AND IMMUNITY}. WASHINGTON: The American Society for Microbiology, 2021, roč.~89, č.~8, s.~1-17. ISSN~0019-9567. Dostupné z: https://doi.org/10.1128/IAI.00105-21.

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