Determining factors for the nano-biocompatibility of cobalt
oxide nanoparticles: proximal discrepancy in intrinsic atomic
interactions at differential vicinage

J 2021

Determining factors for the nano-biocompatibility of cobalt oxide nanoparticles: proximal discrepancy in intrinsic atomic interactions at differential vicinage

VERMA, Suresh K.; Pritam Kumar PANDA; Puja KUMARI; Paritosh PATEL; Aryashree ARUNIMA et al.

Základní údaje

Originální název

Determining factors for the nano-biocompatibility of cobalt oxide nanoparticles: proximal discrepancy in intrinsic atomic interactions at differential vicinage

Autoři

Vydání

Green Chemistry, CAMBRIDGE, ROYAL SOC CHEMISTRY, 2021, 1463-9262

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 11.034

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00123961

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

cobalt oxide nanoparticles; environmental and biomedical nanotoxicity; oxidative stress

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 1. 2022 22:50, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

The abounding use of cobalt oxide nanoparticles (Co3O4) requires a detailed understanding of their environmental and biomedical nanotoxicity and an eminent solution to the associated hazards; molecular and atomic aspects of the subject are poorly understood. This study reconnoiters the in vitro and in vivo nanotoxicity of Co3O4 nanoparticles using human colon cell lines and the embryonic zebrafish model. The synthesis of Co3O4 nanoparticles (G-CoONP) is delineated via the deployment of a medicinal herb, Calotropis gigantea, as an alternative greener solution; stable G-CoONP with a size of 41 +/- 15 nm are attainable. Gas chromatography-mass spectroscopy (GCMS) analysis revealed the role of floral extract biomolecules in G-CoO NP synthesis. The in vitro and in vivo effects are accompanied by dose-dependent exposure at the molecular level by eliciting Sod1 and P53 genes up to 8.2 and 5.2 fold leading to a significant change in the reactive oxygen species and apoptosis level. It unraveled the toxicity of the cobalt oxide NP as increased apoptosis elicited by higher oxidative stress due to the accumulation and internalization of nanoparticles in cells and embryos. Green synthesized G-CoONP exhibited higher biocompatibility than commercial C-CoONP with reduced apoptosis and ROS in both human colon cell lines and zebrafish embryos. In silico analysis portrayed the intrinsic atomic interaction of Co3O4 NP with cysteine, arginine, and histidine of oxidative stress (SOD1/sod1) and apoptosis (TP53/tp53) proteins leading to dysregulation of their structural and functional integrity in human and zebrafish, respectively. A proximal discrepancy in intrinsic atomic interaction due to the H-bonding and hydrophobic interaction at the differential in vitro and in vivo vicinage served as a key determinant factor for the cellular biocompatibility of Co3O4 nanoparticles.

Citovat

VERMA, Suresh K.; Pritam Kumar PANDA; Puja KUMARI; Paritosh PATEL; Aryashree ARUNIMA; Ealisha JHA; Shaheen HUSAIN; Ravi PRAKASH; Roland HERGENRODER; Yogendra Kumar MISHRA; Rajeev AHUJA; Rajender S. VARMA a Mrutyunjay SUAR. Determining factors for the nano-biocompatibility of cobalt oxide nanoparticles: proximal discrepancy in intrinsic atomic interactions at differential vicinage. Green Chemistry. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2021, roč. 23, č. 9, s. 3439-3458. ISSN 1463-9262. Dostupné z: https://doi.org/10.1039/d1gc00571e.

@article{1827277,
   author = {Verma, Suresh K. and Panda, Pritam Kumar and Kumari, Puja and Patel, Paritosh and Arunima, Aryashree and Jha, Ealisha and Husain, Shaheen and Prakash, Ravi and Hergenroder, Roland and Mishra, Yogendra Kumar and Ahuja, Rajeev and Varma, Rajender S. and Suar, Mrutyunjay},
   article_location = {CAMBRIDGE},
   article_number = {9},
   doi = {https://doi.org/10.1039/d1gc00571e},
   keywords = {cobalt oxide nanoparticles; environmental and biomedical nanotoxicity; oxidative stress},
   language = {eng},
   issn = {1463-9262},
   journal = {Green Chemistry},
   title = {Determining factors for the nano-biocompatibility of cobalt oxide nanoparticles: proximal discrepancy in intrinsic atomic interactions at differential vicinage},
   url = {https://pubs.rsc.org/en/content/articlelanding/2021/GC/D1GC00571E},
   volume = {23},
   year = {2021}
}

TY  - JOUR
ID  - 1827277
AU  - Verma, Suresh K. - Panda, Pritam Kumar - Kumari, Puja - Patel, Paritosh - Arunima, Aryashree - Jha, Ealisha - Husain, Shaheen - Prakash, Ravi - Hergenroder, Roland - Mishra, Yogendra Kumar - Ahuja, Rajeev - Varma, Rajender S. - Suar, Mrutyunjay
PY  - 2021
TI  - Determining factors for the nano-biocompatibility of cobalt oxide nanoparticles: proximal discrepancy in intrinsic atomic interactions at differential vicinage
JF  - Green Chemistry
VL  - 23
IS  - 9
SP  - 3439-3458
EP  - 3439-3458
PB  - ROYAL SOC CHEMISTRY
SN  - 14639262
KW  - cobalt oxide nanoparticles
KW  - environmental and biomedical nanotoxicity
KW  - oxidative stress
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/GC/D1GC00571E
N2  - The abounding use of cobalt oxide nanoparticles (Co3O4) requires a detailed understanding of their environmental and biomedical nanotoxicity and an eminent solution to the associated hazards; molecular and atomic aspects of the subject are poorly understood. This study reconnoiters the in vitro and in vivo nanotoxicity of Co3O4 nanoparticles using human colon cell lines and the embryonic zebrafish model. The synthesis of Co3O4 nanoparticles (G-CoONP) is delineated via the deployment of a medicinal herb, Calotropis gigantea, as an alternative greener solution; stable G-CoONP with a size of 41 +/- 15 nm are attainable. Gas chromatography-mass spectroscopy (GCMS) analysis revealed the role of floral extract biomolecules in G-CoO NP synthesis. The in vitro and in vivo effects are accompanied by dose-dependent exposure at the molecular level by eliciting Sod1 and P53 genes up to 8.2 and 5.2 fold leading to a significant change in the reactive oxygen species and apoptosis level. It unraveled the toxicity of the cobalt oxide NP as increased apoptosis elicited by higher oxidative stress due to the accumulation and internalization of nanoparticles in cells and embryos. Green synthesized G-CoONP exhibited higher biocompatibility than commercial C-CoONP with reduced apoptosis and ROS in both human colon cell lines and zebrafish embryos. In silico analysis portrayed the intrinsic atomic interaction of Co3O4 NP with cysteine, arginine, and histidine of oxidative stress (SOD1/sod1) and apoptosis (TP53/tp53) proteins leading to dysregulation of their structural and functional integrity in human and zebrafish, respectively. A proximal discrepancy in intrinsic atomic interaction due to the H-bonding and hydrophobic interaction at the differential in vitro and in vivo vicinage served as a key determinant factor for the cellular biocompatibility of Co3O4 nanoparticles.
ER  -

VERMA, Suresh K.; Pritam Kumar PANDA; Puja KUMARI; Paritosh PATEL; Aryashree ARUNIMA; Ealisha JHA; Shaheen HUSAIN; Ravi PRAKASH; Roland HERGENRODER; Yogendra Kumar MISHRA; Rajeev AHUJA; Rajender S. VARMA a Mrutyunjay SUAR. Determining factors for the nano-biocompatibility of cobalt oxide nanoparticles: proximal discrepancy in intrinsic atomic interactions at differential vicinage. \textit{Green Chemistry}. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2021, roč.~23, č.~9, s.~3439-3458. ISSN~1463-9262. Dostupné z: https://doi.org/10.1039/d1gc00571e.

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