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@inproceedings{1827944,
author = {Plesinger, F. and Halamek, J. and Chládek, Jan and Jurak, P. and Ivora, A. and Doležalová, Irena and Koriťáková, Eva and Jurková, Tereza and Chrastina, Jan and Brázdil, Milan},
address = {Neuveden},
booktitle = {43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society},
doi = {http://dx.doi.org/10.1109/EMBC46164.2021.9629577},
edition = {30 10 2021},
keywords = {Pre-implant Heart Activity; Vagal Nerve Stimulation Therapy; Epileptic Patients},
howpublished = {elektronická verze "online"},
language = {eng},
location = {Neuveden},
pages = {5816-5819},
publisher = {IEEE},
title = {Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients},
url = {https://ieeexplore.ieee.org/document/9629577},
year = {2021}
}
TY - JOUR
ID - 1827944
AU - Plesinger, F. - Halamek, J. - Chládek, Jan - Jurak, P. - Ivora, A. - Doležalová, Irena - Koriťáková, Eva - Jurková, Tereza - Chrastina, Jan - Brázdil, Milan
PY - 2021
TI - Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients
PB - IEEE
CY - Neuveden
KW - Pre-implant Heart Activity
KW - Vagal Nerve Stimulation Therapy
KW - Epileptic Patients
UR - https://ieeexplore.ieee.org/document/9629577
N2 - Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures – mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay.Clinical Relevance— Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments.
ER -
PLESINGER, F., J. HALAMEK, Jan CHLÁDEK, P. JURAK, A. IVORA, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Tereza JURKOVÁ, Jan CHRASTINA a Milan BRÁZDIL. Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients. Online. In \textit{43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society}. 30 10 2021. Neuveden: IEEE, 2021, s.~5816-5819. ISSN~2375-7477. Dostupné z: https://dx.doi.org/10.1109/EMBC46164.2021.9629577.
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