Umbilical Cord Mesenchymal Stromal Cells for Cartilage
Regeneration Applications

J 2022

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications

RUSSO, E.; M. CAPRNDA; Peter KRUŽLIAK; P. G. CONALDI; C. V. BORLONGAN et al.

Základní údaje

Originální název

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications

Autoři

RUSSO, E.; M. CAPRNDA; Peter KRUŽLIAK; P. G. CONALDI; C. V. BORLONGAN a G. LA ROCCA

Vydání

Stem Cells International, London, HINDAWI LTD, 2022, 1687-966X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.300

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/22:00125317

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Umbilical Cord Mesenchymal Stromal Cells; Cartilage Regeneration Applications

Štítky

14110121, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 1. 2022 10:37, Mgr. Tereza Miškechová

Anotace

V originále

Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.

Citovat

RUSSO, E.; M. CAPRNDA; Peter KRUŽLIAK; P. G. CONALDI; C. V. BORLONGAN a G. LA ROCCA. Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications. Stem Cells International. London: HINDAWI LTD, 2022, roč. 2022, January 2022, s. 1-23. ISSN 1687-966X. Dostupné z: https://doi.org/10.1155/2022/2454168.

@article{1829389,
   author = {Russo, E. and Caprnda, M. and Kružliak, Peter and Conaldi, P. G. and Borlongan, C. V. and La Rocca, G.},
   article_location = {London},
   article_number = {January 2022},
   doi = {https://doi.org/10.1155/2022/2454168},
   keywords = {Umbilical Cord Mesenchymal Stromal Cells; Cartilage Regeneration Applications},
   language = {eng},
   issn = {1687-966X},
   journal = {Stem Cells International},
   title = {Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications},
   url = {https://www.hindawi.com/journals/sci/2022/2454168/},
   volume = {2022},
   year = {2022}
}

TY  - JOUR
ID  - 1829389
AU  - Russo, E. - Caprnda, M. - Kružliak, Peter - Conaldi, P. G. - Borlongan, C. V. - La Rocca, G.
PY  - 2022
TI  - Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications
JF  - Stem Cells International
VL  - 2022
IS  - January 2022
SP  - 1-23
EP  - 1-23
PB  - HINDAWI LTD
SN  - 1687966X
KW  - Umbilical Cord Mesenchymal Stromal Cells
KW  - Cartilage Regeneration Applications
UR  - https://www.hindawi.com/journals/sci/2022/2454168/
N2  - Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.
ER  -

RUSSO, E.; M. CAPRNDA; Peter KRUŽLIAK; P. G. CONALDI; C. V. BORLONGAN a G. LA ROCCA. Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications. \textit{Stem Cells International}. London: HINDAWI LTD, 2022, roč.~2022, January 2022, s.~1-23. ISSN~1687-966X. Dostupné z: https://doi.org/10.1155/2022/2454168.

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