High CD4-to-CD8 ratio identifies an at-risk population
susceptible to lethal COVID-19

J 2022

High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19

ZUANI DE, Marco; Petra LÁZNIČKOVÁ; Veronika TOMÁŠKOVÁ; Martina DVONČOVÁ; Giancarlo FORTE et al.

Základní údaje

Originální název

High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19

Autoři

ZUANI DE, Marco; Petra LÁZNIČKOVÁ ; Veronika TOMÁŠKOVÁ; Martina DVONČOVÁ; Giancarlo FORTE; Gorazd Bernard STOKIN; Vladimír ŠRÁMEK; Martin HELÁN a Jan FRIČ

Vydání

Scandinavian journal of immunology, HOBOKEN, WILEY, 2022, 0300-9475

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Slovinsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.700

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/22:00125332

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

CD4-to-CD8 ratio; COVID-19; Intensive care unit; SARS-CoV-2; T cells; TEMRA

Štítky

14110122, 14110513, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 7. 2022 10:29, Mgr. Tereza Miškechová

Anotace

V originále

Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU.

Citovat

ZUANI DE, Marco; Petra LÁZNIČKOVÁ; Veronika TOMÁŠKOVÁ; Martina DVONČOVÁ; Giancarlo FORTE; Gorazd Bernard STOKIN; Vladimír ŠRÁMEK; Martin HELÁN a Jan FRIČ. High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19. Scandinavian journal of immunology. HOBOKEN: WILEY, 2022, roč. 95, č. 3, s. 1-11. ISSN 0300-9475. Dostupné z: https://doi.org/10.1111/sji.13125.

@article{1830717,
   author = {Zuani De, Marco and Lázničková, Petra and Tomášková, Veronika and Dvončová, Martina and Forte, Giancarlo and Stokin, Gorazd Bernard and Šrámek, Vladimír and Helán, Martin and Frič, Jan},
   article_location = {HOBOKEN},
   article_number = {3},
   doi = {https://doi.org/10.1111/sji.13125},
   keywords = {CD4-to-CD8 ratio; COVID-19; Intensive care unit; SARS-CoV-2; T cells; TEMRA},
   language = {eng},
   issn = {0300-9475},
   journal = {Scandinavian journal of immunology},
   title = {High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/sji.13125},
   volume = {95},
   year = {2022}
}

TY  - JOUR
ID  - 1830717
AU  - Zuani De, Marco - Lázničková, Petra - Tomášková, Veronika - Dvončová, Martina - Forte, Giancarlo - Stokin, Gorazd Bernard - Šrámek, Vladimír - Helán, Martin - Frič, Jan
PY  - 2022
TI  - High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19
JF  - Scandinavian journal of immunology
VL  - 95
IS  - 3
SP  - 1-11
EP  - 1-11
PB  - WILEY
SN  - 03009475
KW  - CD4-to-CD8 ratio
KW  - COVID-19
KW  - Intensive care unit
KW  - SARS-CoV-2
KW  - T cells
KW  - TEMRA
UR  - https://onlinelibrary.wiley.com/doi/10.1111/sji.13125
N2  - Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU.
ER  -

ZUANI DE, Marco; Petra LÁZNIČKOVÁ; Veronika TOMÁŠKOVÁ; Martina DVONČOVÁ; Giancarlo FORTE; Gorazd Bernard STOKIN; Vladimír ŠRÁMEK; Martin HELÁN a Jan FRIČ. High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19. \textit{Scandinavian journal of immunology}. HOBOKEN: WILEY, 2022, roč.~95, č.~3, s.~1-11. ISSN~0300-9475. Dostupné z: https://doi.org/10.1111/sji.13125.

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