| ZUANI DE, Marco, Petra LÁZNIČKOVÁ, Veronika TOMÁŠKOVÁ, Martina DVONČOVÁ, Giancarlo FORTE, Gorazd Bernard STOKIN, Vladimír ŠRÁMEK, Martin HELÁN a Jan FRIČ. High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19. Scandinavian journal of immunology. HOBOKEN: WILEY, 2022, roč. 95, č. 3, s. 1-11. ISSN 0300-9475. Dostupné z: https://dx.doi.org/10.1111/sji.13125. |
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@article{1830717,
author = {Zuani De, Marco and Lázničková, Petra and Tomášková, Veronika and Dvončová, Martina and Forte, Giancarlo and Stokin, Gorazd Bernard and Šrámek, Vladimír and Helán, Martin and Frič, Jan},
article_location = {HOBOKEN},
article_number = {3},
doi = {http://dx.doi.org/10.1111/sji.13125},
keywords = {CD4-to-CD8 ratio; COVID-19; Intensive care unit; SARS-CoV-2; T cells; TEMRA},
language = {eng},
issn = {0300-9475},
journal = {Scandinavian journal of immunology},
title = {High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19},
url = {https://onlinelibrary.wiley.com/doi/10.1111/sji.13125},
volume = {95},
year = {2022}
}
TY - JOUR
ID - 1830717
AU - Zuani De, Marco - Lázničková, Petra - Tomášková, Veronika - Dvončová, Martina - Forte, Giancarlo - Stokin, Gorazd Bernard - Šrámek, Vladimír - Helán, Martin - Frič, Jan
PY - 2022
TI - High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19
JF - Scandinavian journal of immunology
VL - 95
IS - 3
SP - 1-11
EP - 1-11
PB - WILEY
SN - 03009475
KW - CD4-to-CD8 ratio
KW - COVID-19
KW - Intensive care unit
KW - SARS-CoV-2
KW - T cells
KW - TEMRA
UR - https://onlinelibrary.wiley.com/doi/10.1111/sji.13125
N2 - Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU.
ER -
ZUANI DE, Marco, Petra LÁZNIČKOVÁ, Veronika TOMÁŠKOVÁ, Martina DVONČOVÁ, Giancarlo FORTE, Gorazd Bernard STOKIN, Vladimír ŠRÁMEK, Martin HELÁN a Jan FRIČ. High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19. \textit{Scandinavian journal of immunology}. HOBOKEN: WILEY, 2022, roč.~95, č.~3, s.~1-11. ISSN~0300-9475. Dostupné z: https://dx.doi.org/10.1111/sji.13125.
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