2022
Práškové částice pro plicní podání
KARAS, Jakub; David VETCHÝ a Jan GAJDZIOKZákladní údaje
Originální název
Práškové částice pro plicní podání
Název anglicky
Dry Powder Particles for Pulmonary Application
Autoři
KARAS, Jakub; David VETCHÝ a Jan GAJDZIOK
Vydání
CHEMICKÉ LISTY, Praha, Czech Society of Chemical Engineering, 2022, 0009-2770
Další údaje
Jazyk
čeština
Typ výsledku
Článek v odborném periodiku
Obor
30104 Pharmacology and pharmacy
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 0.600
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14160/22:00125336
Organizační jednotka
Farmaceutická fakulta
UT WoS
EID Scopus
Klíčová slova anglicky
Artificial lungs; Dry powder inhalation; Large porous particles; Lung particle deposition; Particles preparation methods; Spray drying
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 9. 11. 2022 15:47, JUDr. Sabina Gajdzioková
V originále
The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.
Anglicky
The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.
Návaznosti
| MUNI/A/1213/2020, interní kód MU |
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