The Role of Autophagy and lncRNAs in the Maintenance of Cancer
Stem Cells

J 2021

The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells

JAHANGIRI, L.; T. ISHOLA; P. PUCCI; R.M. TRIGG; J. PEREIRA et al.

Základní údaje

Originální název

The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells

Autoři

JAHANGIRI, L.; T. ISHOLA; P. PUCCI; R.M. TRIGG; J. PEREIRA; J.A. WILLIAMS; M.L. CAVANAGH; G.V. GKOUTOS; L. TSAPROUNI a Suzanne Dawn TURNER

Vydání

Cancers, BASEL, MDPI, 2021, 2072-6694

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.575

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/21:00124198

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

cancer stem cells (CSCs); tumour microenvironment; solid cancers; haematological malignancies; autophagy; LncRNAs

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 2. 2022 14:52, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Simple Summary Cancer stem cells (CSCs) represent a distinct cancer subpopulation that can influence the tumour microenvironment, in addition to cancer progression and relapse. A multitude of factors including CSC properties, long noncoding RNAs (lncRNAs), and autophagy play pivotal roles in maintaining CSCs. We discuss the methods of detection of CSCs and how our knowledge of regulatory and cellular processes, and their interaction with the microenvironment, may lead to more effective targeting of these cells. Autophagy and lncRNAs can regulate several cellular functions, thereby promoting stemness factors and CSC properties, hence understanding this triangle and its associated signalling networks can lead to enhanced therapy response, while paving the way for the development of novel therapeutic approaches. Cancer stem cells (CSCs) possess properties such as self-renewal, resistance to apoptotic cues, quiescence, and DNA-damage repair capacity. Moreover, CSCs strongly influence the tumour microenvironment (TME) and may account for cancer progression, recurrence, and relapse. CSCs represent a distinct subpopulation in tumours and the detection, characterisation, and understanding of the regulatory landscape and cellular processes that govern their maintenance may pave the way to improving prognosis, selective targeted therapy, and therapy outcomes. In this review, we have discussed the characteristics of CSCs identified in various cancer types and the role of autophagy and long noncoding RNAs (lncRNAs) in maintaining the homeostasis of CSCs. Further, we have discussed methods to detect CSCs and strategies for treatment and relapse, taking into account the requirement to inhibit CSC growth and survival within the complex backdrop of cellular processes, microenvironmental interactions, and regulatory networks associated with cancer. Finally, we critique the computationally reinforced triangle of factors inclusive of CSC properties, the process of autophagy, and lncRNA and their associated networks with respect to hypoxia, epithelial-to-mesenchymal transition (EMT), and signalling pathways.

Citovat

JAHANGIRI, L.; T. ISHOLA; P. PUCCI; R.M. TRIGG; J. PEREIRA; J.A. WILLIAMS; M.L. CAVANAGH; G.V. GKOUTOS; L. TSAPROUNI a Suzanne Dawn TURNER. The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells. Cancers. BASEL: MDPI, 2021, roč. 13, č. 6, s. „1239“, 31 s. ISSN 2072-6694. Dostupné z: https://doi.org/10.3390/cancers13061239.

@article{1834789,
   author = {Jahangiri, L. and Ishola, T. and Pucci, P. and Trigg, R.M. and Pereira, J. and Williams, J.A. and Cavanagh, M.L. and Gkoutos, G.V. and Tsaprouni, L. and Turner, Suzanne Dawn},
   article_location = {BASEL},
   article_number = {6},
   doi = {https://doi.org/10.3390/cancers13061239},
   keywords = {cancer stem cells (CSCs); tumour microenvironment; solid cancers; haematological malignancies; autophagy; LncRNAs},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells},
   url = {https://www.mdpi.com/2072-6694/13/6/1239},
   volume = {13},
   year = {2021}
}

TY  - JOUR
ID  - 1834789
AU  - Jahangiri, L. - Ishola, T. - Pucci, P. - Trigg, R.M. - Pereira, J. - Williams, J.A. - Cavanagh, M.L. - Gkoutos, G.V. - Tsaprouni, L. - Turner, Suzanne Dawn
PY  - 2021
TI  - The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells
JF  - Cancers
VL  - 13
IS  - 6
SP  - „1239“
EP  - „1239“
PB  - MDPI
SN  - 20726694
KW  - cancer stem cells (CSCs)
KW  - tumour microenvironment
KW  - solid cancers
KW  - haematological malignancies
KW  - autophagy
KW  - LncRNAs
UR  - https://www.mdpi.com/2072-6694/13/6/1239
N2  - Simple Summary Cancer stem cells (CSCs) represent a distinct cancer subpopulation that can influence the tumour microenvironment, in addition to cancer progression and relapse. A multitude of factors including CSC properties, long noncoding RNAs (lncRNAs), and autophagy play pivotal roles in maintaining CSCs. We discuss the methods of detection of CSCs and how our knowledge of regulatory and cellular processes, and their interaction with the microenvironment, may lead to more effective targeting of these cells. Autophagy and lncRNAs can regulate several cellular functions, thereby promoting stemness factors and CSC properties, hence understanding this triangle and its associated signalling networks can lead to enhanced therapy response, while paving the way for the development of novel therapeutic approaches. Cancer stem cells (CSCs) possess properties such as self-renewal, resistance to apoptotic cues, quiescence, and DNA-damage repair capacity. Moreover, CSCs strongly influence the tumour microenvironment (TME) and may account for cancer progression, recurrence, and relapse. CSCs represent a distinct subpopulation in tumours and the detection, characterisation, and understanding of the regulatory landscape and cellular processes that govern their maintenance may pave the way to improving prognosis, selective targeted therapy, and therapy outcomes. In this review, we have discussed the characteristics of CSCs identified in various cancer types and the role of autophagy and long noncoding RNAs (lncRNAs) in maintaining the homeostasis of CSCs. Further, we have discussed methods to detect CSCs and strategies for treatment and relapse, taking into account the requirement to inhibit CSC growth and survival within the complex backdrop of cellular processes, microenvironmental interactions, and regulatory networks associated with cancer. Finally, we critique the computationally reinforced triangle of factors inclusive of CSC properties, the process of autophagy, and lncRNA and their associated networks with respect to hypoxia, epithelial-to-mesenchymal transition (EMT), and signalling pathways.
ER  -

JAHANGIRI, L.; T. ISHOLA; P. PUCCI; R.M. TRIGG; J. PEREIRA; J.A. WILLIAMS; M.L. CAVANAGH; G.V. GKOUTOS; L. TSAPROUNI a Suzanne Dawn TURNER. The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells. \textit{Cancers}. BASEL: MDPI, 2021, roč.~13, č.~6, s.~„1239“, 31 s. ISSN~2072-6694. Dostupné z: https://doi.org/10.3390/cancers13061239.

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