Endogenously-Produced Hyaluronan and Its Potential to Regulate
the Development of Peritoneal Adhesions

J 2022

Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions

KOCURKOVÁ, Anna; Kristina NESPOROVA; Miriam SANDANUSOVÁ; Michaela KERBEROVÁ; Kateřina LEHKÁ et al.

Základní údaje

Originální název

Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions

Autoři

KOCURKOVÁ, Anna; Kristina NESPOROVA; Miriam SANDANUSOVÁ; Michaela KERBEROVÁ; Kateřina LEHKÁ; Vladimír VELEBNÝ; Lukáš KUBALA a Gabriela AMBROŽOVÁ

Vydání

Biomolecules, MDPI, 2022, 2218-273X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.500

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00125404

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

peritoneal adhesion; fibrosis; hyaluronan; mesothelial cell; metabolism; inflammation; mesothelial-to-mesenchymal transition

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 25. 11. 2024 14:13, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Formation of peritoneal adhesions (PA) is one of the major complications following intra-abdominal surgery. It is primarily caused by activation of the mesothelial layer and underlying tissues in the peritoneal membrane resulting in the transition of mesothelial cells (MCs) and fibroblasts to a pro-fibrotic phenotype. Pro-fibrotic transition of MCs-mesothelial-to-mesenchymal transition (MMT), and fibroblasts activation to myofibroblasts are interconnected to changes in cellular metabolism and culminate in the deposition of extracellular matrix (ECM) in the form of fibrotic tissue between injured sides in the abdominal cavity. However, ECM is not only a mechanical scaffold of the newly synthetized tissue but reciprocally affects fibrosis development. Hyaluronan (HA), an important component of ECM, is a non-sulfated glycosaminoglycan consisting of N-acetyl-D-glucosamine (GlcNAc) and D-glucuronic acid (GlcUA) that can affect the majority of processes involved in PA formation. This review considers the role of endogenously produced HA in the context of different fibrosis-related pathologies and its overlap in the development of PA.

Citovat

KOCURKOVÁ, Anna; Kristina NESPOROVA; Miriam SANDANUSOVÁ; Michaela KERBEROVÁ; Kateřina LEHKÁ; Vladimír VELEBNÝ; Lukáš KUBALA a Gabriela AMBROŽOVÁ. Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions. Biomolecules. MDPI, 2022, roč. 12, č. 1, s. 1-17. ISSN 2218-273X. Dostupné z: https://doi.org/10.3390/biom12010045.

@article{1835118,
   author = {Kocurková, Anna and Nesporova, Kristina and Sandanusová, Miriam and Kerberová, Michaela and Lehká, Kateřina and Velebný, Vladimír and Kubala, Lukáš and Ambrožová, Gabriela},
   article_number = {1},
   doi = {https://doi.org/10.3390/biom12010045},
   keywords = {peritoneal adhesion; fibrosis; hyaluronan; mesothelial cell; metabolism; inflammation; mesothelial-to-mesenchymal transition},
   language = {eng},
   issn = {2218-273X},
   journal = {Biomolecules},
   title = {Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions},
   url = {https://www.mdpi.com/2218-273X/12/1/45},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 1835118
AU  - Kocurková, Anna - Nesporova, Kristina - Sandanusová, Miriam - Kerberová, Michaela - Lehká, Kateřina - Velebný, Vladimír - Kubala, Lukáš - Ambrožová, Gabriela
PY  - 2022
TI  - Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions
JF  - Biomolecules
VL  - 12
IS  - 1
SP  - 1-17
EP  - 1-17
PB  - MDPI
SN  - 2218273X
KW  - peritoneal adhesion
KW  - fibrosis
KW  - hyaluronan
KW  - mesothelial cell
KW  - metabolism
KW  - inflammation
KW  - mesothelial-to-mesenchymal transition
UR  - https://www.mdpi.com/2218-273X/12/1/45
N2  - Formation of peritoneal adhesions (PA) is one of the major complications following intra-abdominal surgery. It is primarily caused by activation of the mesothelial layer and underlying tissues in the peritoneal membrane resulting in the transition of mesothelial cells (MCs) and fibroblasts to a pro-fibrotic phenotype. Pro-fibrotic transition of MCs-mesothelial-to-mesenchymal transition (MMT), and fibroblasts activation to myofibroblasts are interconnected to changes in cellular metabolism and culminate in the deposition of extracellular matrix (ECM) in the form of fibrotic tissue between injured sides in the abdominal cavity. However, ECM is not only a mechanical scaffold of the newly synthetized tissue but reciprocally affects fibrosis development. Hyaluronan (HA), an important component of ECM, is a non-sulfated glycosaminoglycan consisting of N-acetyl-D-glucosamine (GlcNAc) and D-glucuronic acid (GlcUA) that can affect the majority of processes involved in PA formation. This review considers the role of endogenously produced HA in the context of different fibrosis-related pathologies and its overlap in the development of PA.
ER  -

KOCURKOVÁ, Anna; Kristina NESPOROVA; Miriam SANDANUSOVÁ; Michaela KERBEROVÁ; Kateřina LEHKÁ; Vladimír VELEBNÝ; Lukáš KUBALA a Gabriela AMBROŽOVÁ. Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions. \textit{Biomolecules}. MDPI, 2022, roč.~12, č.~1, s.~1-17. ISSN~2218-273X. Dostupné z: https://doi.org/10.3390/biom12010045.

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