The Contribution of Autophagy and LncRNAs to MYC-Driven Gene
Regulatory Networks in Cancers

J 2021

The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

JAHANGIRI, L.; P. PUCCI; T. ISHOLA; R.M. TRIGG; J.A. WILLIAMS et al.

Základní údaje

Originální název

The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

Autoři

JAHANGIRI, L.; P. PUCCI; T. ISHOLA; R.M. TRIGG; J.A. WILLIAMS; J. PEREIRA; M.L. CAVANAGH; Suzanne Dawn TURNER; G.V. GKOUTOS a L. TSAPROUNI

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2021, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/21:00124232

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

MYC; gene regulatory networks (GRNs); autophagy; lncRNAs

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 5. 2022 13:38, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.

Citovat

JAHANGIRI, L.; P. PUCCI; T. ISHOLA; R.M. TRIGG; J.A. WILLIAMS; J. PEREIRA; M.L. CAVANAGH; Suzanne Dawn TURNER; G.V. GKOUTOS a L. TSAPROUNI. The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2021, roč. 22, č. 16, s. 8527-8546. ISSN 1422-0067. Dostupné z: https://doi.org/10.3390/ijms22168527.

@article{1835962,
   author = {Jahangiri, L. and Pucci, P. and Ishola, T. and Trigg, R.M. and Williams, J.A. and Pereira, J. and Cavanagh, M.L. and Turner, Suzanne Dawn and Gkoutos, G.V. and Tsaprouni, L.},
   article_location = {Basel},
   article_number = {16},
   doi = {https://doi.org/10.3390/ijms22168527},
   keywords = {MYC; gene regulatory networks (GRNs); autophagy; lncRNAs},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers},
   url = {https://www.mdpi.com/1422-0067/22/16/8527},
   volume = {22},
   year = {2021}
}

TY  - JOUR
ID  - 1835962
AU  - Jahangiri, L. - Pucci, P. - Ishola, T. - Trigg, R.M. - Williams, J.A. - Pereira, J. - Cavanagh, M.L. - Turner, Suzanne Dawn - Gkoutos, G.V. - Tsaprouni, L.
PY  - 2021
TI  - The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
JF  - International Journal of Molecular Sciences
VL  - 22
IS  - 16
SP  - 8527
EP  - 8527
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - MYC
KW  - gene regulatory networks (GRNs)
KW  - autophagy
KW  - lncRNAs
UR  - https://www.mdpi.com/1422-0067/22/16/8527
N2  - MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.
ER  -

JAHANGIRI, L.; P. PUCCI; T. ISHOLA; R.M. TRIGG; J.A. WILLIAMS; J. PEREIRA; M.L. CAVANAGH; Suzanne Dawn TURNER; G.V. GKOUTOS a L. TSAPROUNI. The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2021, roč.~22, č.~16, s.~8527-8546. ISSN~1422-0067. Dostupné z: https://doi.org/10.3390/ijms22168527.

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