DIANA-miRGen v4: indexing promoters and regulators for more
than 1500 microRNAs

J 2021

DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs

PERDIKOPANIS, N., Georgios GEORGAKILAS, D. GRIGORIADIS, V. PIERROS, I. KAVAKIOTIS et. al.

Základní údaje

Originální název

DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs

Autoři

PERDIKOPANIS, N., Georgios GEORGAKILAS (300 Řecko, domácí), D. GRIGORIADIS, V. PIERROS, I. KAVAKIOTIS, Panagiotis ALEXIOU (300 Řecko, garant, domácí) a A. HATZIGEORGIOU

Vydání

Nucleic acids research, Oxford, Oxford University Press, 2021, 0305-1048

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 19.160

Kód RIV

RIV/00216224:14740/21:00124298

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1093/nar/gkaa1060

UT WoS

000608437800021

Klíčová slova anglicky

ANALYSIS GENE-EXPRESSIONDNA ELEMENTSENCYCLOPEDIA

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 2. 2022 13:26, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Deregulation ofmicroRNA (miRNA) expression plays a critical role in the transition from a physiological to a pathological state. The accurate miRNA promoter identification in multiple cell types is a fundamental endeavor towards understanding and characterizing the underlying mechanisms of both physiological as well as pathological conditions. DIANA-miRGen v4 (www.microrna.gr/ mirgenv4) provides cell type specific miRNA transcription start sites (TSSs) for over 1500 miRNAs retrieved from the analysis of >1000 cap analysis of gene expression (CAGE) samples corresponding to 133 tissues, cell lines and primary cells available in FANTOM repository. MiRNA TSS locations were associated with transcription factor binding site (TFBSs) annotation, for >280 TFs, derived from analyzing the majority of ENCODE ChIP-Seq datasets. For the first time, clusters of cell types having common miRNA TSSs are characterized and provided through a user friendly interface with multiple layers of customization. DIANA-miRGen v4 significantly improves our understanding of miRNA biogenesis regulation at the transcriptional level by providing a unique integration of high-quality annotations for hundreds of cell specific miRNA promoters with experimentally derived TFBSs.

Návaznosti

EF16_027/0008360, projekt VaV

Název: Postdoc@MUNI

Citovat

PERDIKOPANIS, N., Georgios GEORGAKILAS, D. GRIGORIADIS, V. PIERROS, I. KAVAKIOTIS, Panagiotis ALEXIOU a A. HATZIGEORGIOU. DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs. Nucleic acids research. Oxford: Oxford University Press, 2021, roč. 49, D1, s. "D151"-"D159", 9 s. ISSN 0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gkaa1060.

@article{1837277,
   author = {Perdikopanis, N. and Georgakilas, Georgios and Grigoriadis, D. and Pierros, V. and Kavakiotis, I. and Alexiou, Panagiotis and Hatzigeorgiou, A.},
   article_location = {Oxford},
   article_number = {D1},
   doi = {http://dx.doi.org/10.1093/nar/gkaa1060},
   keywords = {ANALYSIS GENE-EXPRESSIONDNA ELEMENTSENCYCLOPEDIA},
   language = {eng},
   issn = {0305-1048},
   journal = {Nucleic acids research},
   title = {DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs},
   url = {https://academic.oup.com/nar/article/49/D1/D151/6007663},
   volume = {49},
   year = {2021}
}

TY  - JOUR
ID  - 1837277
AU  - Perdikopanis, N. - Georgakilas, Georgios - Grigoriadis, D. - Pierros, V. - Kavakiotis, I. - Alexiou, Panagiotis - Hatzigeorgiou, A.
PY  - 2021
TI  - DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs
JF  - Nucleic acids research
VL  - 49
IS  - D1
SP  - "D151"-"D159"
EP  - "D151"-"D159"
PB  - Oxford University Press
SN  - 03051048
KW  - ANALYSIS GENE-EXPRESSIONDNA ELEMENTSENCYCLOPEDIA
UR  - https://academic.oup.com/nar/article/49/D1/D151/6007663
N2  - Deregulation ofmicroRNA (miRNA) expression plays a critical role in the transition from a physiological to a pathological state. The accurate miRNA promoter identification in multiple cell types is a fundamental endeavor towards understanding and characterizing the underlying mechanisms of both physiological as well as pathological conditions. DIANA-miRGen v4 (www.microrna.gr/ mirgenv4) provides cell type specific miRNA transcription start sites (TSSs) for over 1500 miRNAs retrieved from the analysis of >1000 cap analysis of gene expression (CAGE) samples corresponding to 133 tissues, cell lines and primary cells available in FANTOM repository. MiRNA TSS locations were associated with transcription factor binding site (TFBSs) annotation, for >280 TFs, derived from analyzing the majority of ENCODE ChIP-Seq datasets. For the first time, clusters of cell types having common miRNA TSSs are characterized and provided through a user friendly interface with multiple layers of customization. DIANA-miRGen v4 significantly improves our understanding of miRNA biogenesis regulation at the transcriptional level by providing a unique integration of high-quality annotations for hundreds of cell specific miRNA promoters with experimentally derived TFBSs.
ER  -

PERDIKOPANIS, N., Georgios GEORGAKILAS, D. GRIGORIADIS, V. PIERROS, I. KAVAKIOTIS, Panagiotis ALEXIOU a A. HATZIGEORGIOU. DIANA-miRGen v4: indexing promoters and regulators for more than 1500 microRNAs. \textit{Nucleic acids research}. Oxford: Oxford University Press, 2021, roč.~49, D1, s.~''D151''-''D159'', 9 s. ISSN~0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gkaa1060.

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