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@article{1837982,
author = {Bohutinska, M. and Alston, M. and Monnahan, P. and Malík Mandáková, Terezie and Bray, S. and Paajanen, P. and Kolar, F. and Yant, L.},
article_location = {OXFORD},
article_number = {9},
doi = {http://dx.doi.org/10.1093/molbev/msab096},
keywords = {polyploidy; convergence; genome duplication; adaptation},
language = {eng},
issn = {0737-4038},
journal = {Molecular Biology and Evolution},
title = {Novelty and Convergence in Adaptation to Whole Genome Duplication},
url = {https://academic.oup.com/mbe/article/38/9/3910/6203814},
volume = {38},
year = {2021}
}
TY - JOUR
ID - 1837982
AU - Bohutinska, M. - Alston, M. - Monnahan, P. - Malík Mandáková, Terezie - Bray, S. - Paajanen, P. - Kolar, F. - Yant, L.
PY - 2021
TI - Novelty and Convergence in Adaptation to Whole Genome Duplication
JF - Molecular Biology and Evolution
VL - 38
IS - 9
SP - 3910-3924
EP - 3910-3924
PB - OXFORD UNIV PRESS
SN - 07374038
KW - polyploidy
KW - convergence
KW - genome duplication
KW - adaptation
UR - https://academic.oup.com/mbe/article/38/9/3910/6203814
N2 - Whole genome duplication (WGD) can promote adaptation but is disruptive to conserved processes, especially meiosis. Studies in Arabidopsis arenosa revealed a coordinated evolutionary response to WGD involving interacting proteins controlling meiotic crossovers, which are minimized in an autotetraploid (within-species polyploid) to avoid missegregation. Here, we test whether this surprising flexibility of a conserved essential process, meiosis, is recapitulated in an independent WGD system, Cardamine amara, 17 My diverged from A. arenosa. We assess meiotic stability and perform population-based scans for positive selection, contrasting the genomic response to WGD in C. amara with that of A. arenosa. We found in C amara the strongest selection signals at genes with predicted functions thought important to adaptation to WGD: meiosis, chromosome remodeling, cell cycle, and ion transport. However, genomic responses to WGD in the two species differ: minimal ortholog-level convergence emerged, with none of the meiosis genes found in A. arenosa exhibiting strong signal in C amara. This is consistent with our observations of lower meiotic stability and occasional clonal spreading in diploid C amara, suggesting that nascent C. amara autotetraploid lineages were pre-adapted by their diploid lifestyle to survive while enduring reduced meiotic fidelity. However, in contrast to a lack of ortholog convergence, we see process-level and network convergence in DNA management, chromosome organization, stress signaling, and ion homeostasis processes. This gives the first insight into the salient adaptations required to meet the challenges of a WGD state and shows that autopolyploids can utilize multiple evolutionary trajectories to adapt to WGD.
ER -
BOHUTINSKA, M., M. ALSTON, P. MONNAHAN, Terezie MALÍK MANDÁKOVÁ, S. BRAY, P. PAAJANEN, F. KOLAR a L. YANT. Novelty and Convergence in Adaptation to Whole Genome Duplication. \textit{Molecular Biology and Evolution}. OXFORD: OXFORD UNIV PRESS, 2021, roč.~38, č.~9, s.~3910-3924. ISSN~0737-4038. Dostupné z: https://dx.doi.org/10.1093/molbev/msab096.
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