Shannon entropy: A novel parameter for quantifying pentagon
copying performance in non-demented Parkinson's disease
patients

J 2022

Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients

BRABENEC, Luboš; Patrícia KLOBUŠIAKOVÁ; Jiří MEKYSKA a Irena REKTOROVÁ

Základní údaje

Originální název

Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients

Autoři

BRABENEC, Luboš; Patrícia KLOBUŠIAKOVÁ; Jiří MEKYSKA a Irena REKTOROVÁ

Vydání

PARKINSONISM & RELATED DISORDERS, OXFORD, ELSEVIER SCI LTD, 2022, 1353-8020

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.100

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/22:00125465

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

Parkinson's disease; Kinematic analysis; Pentagon copying test; In-air movement; Shannon entropy

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 10:04, Ing. Jana Kuchtová

Anotace

V originále

Introduction: Impaired copy of intersecting pentagons from the Mini-Mental State Examination (MMSE), has been used to assess dementia in Parkinson's disease (PD). We used a digitizing tablet during the pentagon copying test (PCT) as a potential tool for evaluating early cognitive deficits in PD without major cognitive impairment. We also aimed to uncover the neural correlates of the identified parameters using whole-brain magnetic resonance imaging (MRI). Methods: We enrolled 27 patients with PD without major cognitive impairment and 25 age-matched healthy controls (HC). We focused on drawing parameters using a digitizing tablet. Parameters with between-group differences were correlated with cognitive outcomes and were used as covariates in the whole-brain voxel-wise analysis using voxel-based morphometry; familywise error (FWE) threshold p < 0.001. Results: PD patients differed from HC in attention domain z-scores (p < 0.0001). In terms of tablet parameters, the groups differed in Shannon entropy (horizontal in-air, p = 0.003), which quantifies the movements between two strokes. In PD, a correlation was found between the median of Shannon entropy (horizontal in-air) and attention z-scores (R = -0.55, p = 0.006). The VBM revealed an association between our drawing parameter of interest and gray matter (GM) volume variability in the right superior parietal lobe (SPL). Conclusion: Using a digitizing tablet during the PCT, we identified a novel entropy-based parameter that differed between the nondemented PD and HC groups. This in-air parameter correlated with the level of attention and was linked to GM volume variability of the region engaged in spatial attention.

Návaznosti

NU20-04-00294, projekt VaV

Název: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

Investor: Ministerstvo zdravotnictví ČR, Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

734718, interní kód MU

Název: Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology (Akronym: CoBeN)

Investor: Evropská unie, Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Přiložené soubory

PIIS1353802021004442.pdf

Citovat

BRABENEC, Luboš; Patrícia KLOBUŠIAKOVÁ; Jiří MEKYSKA a Irena REKTOROVÁ. Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, 2022, roč. 94, JAN, s. 45-48. ISSN 1353-8020. Dostupné z: https://doi.org/10.1016/j.parkreldis.2021.11.037.

@article{1838646,
   author = {Brabenec, Luboš and Klobušiaková, Patrícia and Mekyska, Jiří and Rektorová, Irena},
   article_location = {OXFORD},
   article_number = {JAN},
   doi = {https://doi.org/10.1016/j.parkreldis.2021.11.037},
   keywords = {Parkinson's disease; Kinematic analysis; Pentagon copying test; In-air movement; Shannon entropy},
   language = {eng},
   issn = {1353-8020},
   journal = {PARKINSONISM & RELATED DISORDERS},
   title = {Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients},
   url = {https://www.sciencedirect.com/science/article/pii/S1353802021004442?via%3Dihub},
   volume = {94},
   year = {2022}
}

TY  - JOUR
ID  - 1838646
AU  - Brabenec, Luboš - Klobušiaková, Patrícia - Mekyska, Jiří - Rektorová, Irena
PY  - 2022
TI  - Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients
JF  - PARKINSONISM & RELATED DISORDERS
VL  - 94
IS  - JAN
SP  - 45-48
EP  - 45-48
PB  - ELSEVIER SCI LTD
SN  - 13538020
KW  - Parkinson's disease
KW  - Kinematic analysis
KW  - Pentagon copying test
KW  - In-air movement
KW  - Shannon entropy
UR  - https://www.sciencedirect.com/science/article/pii/S1353802021004442?via%3Dihub
N2  - Introduction: Impaired copy of intersecting pentagons from the Mini-Mental State Examination (MMSE), has been used to assess dementia in Parkinson's disease (PD). We used a digitizing tablet during the pentagon copying test (PCT) as a potential tool for evaluating early cognitive deficits in PD without major cognitive impairment. We also aimed to uncover the neural correlates of the identified parameters using whole-brain magnetic resonance imaging (MRI). Methods: We enrolled 27 patients with PD without major cognitive impairment and 25 age-matched healthy controls (HC). We focused on drawing parameters using a digitizing tablet. Parameters with between-group differences were correlated with cognitive outcomes and were used as covariates in the whole-brain voxel-wise analysis using voxel-based morphometry; familywise error (FWE) threshold p < 0.001. Results: PD patients differed from HC in attention domain z-scores (p < 0.0001). In terms of tablet parameters, the groups differed in Shannon entropy (horizontal in-air, p = 0.003), which quantifies the movements between two strokes. In PD, a correlation was found between the median of Shannon entropy (horizontal in-air) and attention z-scores (R = -0.55, p = 0.006). The VBM revealed an association between our drawing parameter of interest and gray matter (GM) volume variability in the right superior parietal lobe (SPL). Conclusion: Using a digitizing tablet during the PCT, we identified a novel entropy-based parameter that differed between the nondemented PD and HC groups. This in-air parameter correlated with the level of attention and was linked to GM volume variability of the region engaged in spatial attention.
ER  -

BRABENEC, Luboš; Patrícia KLOBUŠIAKOVÁ; Jiří MEKYSKA a Irena REKTOROVÁ. Shannon entropy: A novel parameter for quantifying pentagon copying performance in non-demented Parkinson's disease patients. \textit{PARKINSONISM \&{}amp; RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2022, roč.~94, JAN, s.~45-48. ISSN~1353-8020. Dostupné z: https://doi.org/10.1016/j.parkreldis.2021.11.037.

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