Technology of Processing Plant Extracts Using an
Aluminometasilicate Porous Carrier into a Solid Dosage Form

J 2022

Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form

KOSTELANSKÁ, Klára, S. KURHAJEC, Sylvie PAVLOKOVÁ, David VETCHÝ, Jan GAJDZIOK et. al.

Základní údaje

Originální název

Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form

Autoři

KOSTELANSKÁ, Klára (203 Česká republika, garant, domácí), S. KURHAJEC, Sylvie PAVLOKOVÁ (203 Česká republika, domácí), David VETCHÝ (203 Česká republika, domácí), Jan GAJDZIOK (203 Česká republika, domácí) a Aleš FRANC (203 Česká republika, domácí)

Vydání

Pharmaceutics, Basel, MDPI, 2022, 1999-4923

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.400

Kód RIV

RIV/00216224:14160/22:00125492

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/pharmaceutics14020248

UT WoS

000764616000001

Klíčová slova anglicky

Adsorption; Antioxidant activity; Liquisolid systems; Magnesium aluminometasilicates; Plant extracts; Porous carriers

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 3. 2022 09:32, Mgr. Sylvie Pavloková, Ph.D.

Anotace

V originále

A method of preparing tablets called liquisolid technique is currently emerging. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). The most common are microcrystalline cellulose (MCC), magnesium aluminometasilicates, silica aerogels, mesoporous silicates, clays, etc. In this study, magnesium aluminometasilicate is used to prepare modified LSS formulations with plant extracts as model drugs dissolved in water (W) or ethanol (E). The modification involves drying tablets in a microwave (MW) and hot air dryer (HA) for a specified period. Powder blends and tablets were evaluated for physical properties, and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). PLS and ANOVA were used to compare tablets properties depending on the composition and technology. The experiment is based on a previous one, in which the plant extracts were processed into tablets using a similar method. Therefore, extending the study to include more plants and the robust statistical evaluation and comparison of the products was a procedure to justify the suitability of the presented method for a wide range of liquid plant extracts. As a result, we obtained tablets with excellent physical properties, including a short disintegration and dissolution, which is problematic in tableted extracts.

Citovat

KOSTELANSKÁ, Klára, S. KURHAJEC, Sylvie PAVLOKOVÁ, David VETCHÝ, Jan GAJDZIOK a Aleš FRANC. Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form. Pharmaceutics. Basel: MDPI, 2022, roč. 14, č. 2, s. 1-20. ISSN 1999-4923. Dostupné z: https://dx.doi.org/10.3390/pharmaceutics14020248.

@article{1839859,
   author = {Kostelanská, Klára and Kurhajec, S. and Pavloková, Sylvie and Vetchý, David and Gajdziok, Jan and Franc, Aleš},
   article_location = {Basel},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/pharmaceutics14020248},
   keywords = {Adsorption; Antioxidant activity; Liquisolid systems; Magnesium aluminometasilicates; Plant extracts; Porous carriers},
   language = {eng},
   issn = {1999-4923},
   journal = {Pharmaceutics},
   title = {Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form},
   url = {https://www.mdpi.com/1999-4923/14/2/248},
   volume = {14},
   year = {2022}
}

TY  - JOUR
ID  - 1839859
AU  - Kostelanská, Klára - Kurhajec, S. - Pavloková, Sylvie - Vetchý, David - Gajdziok, Jan - Franc, Aleš
PY  - 2022
TI  - Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form
JF  - Pharmaceutics
VL  - 14
IS  - 2
SP  - 1-20
EP  - 1-20
PB  - MDPI
SN  - 19994923
KW  - Adsorption
KW  - Antioxidant activity
KW  - Liquisolid systems
KW  - Magnesium aluminometasilicates
KW  - Plant extracts
KW  - Porous carriers
UR  - https://www.mdpi.com/1999-4923/14/2/248
N2  - A method of preparing tablets called liquisolid technique is currently emerging. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). The most common are microcrystalline cellulose (MCC), magnesium aluminometasilicates, silica aerogels, mesoporous silicates, clays, etc. In this study, magnesium aluminometasilicate is used to prepare modified LSS formulations with plant extracts as model drugs dissolved in water (W) or ethanol (E). The modification involves drying tablets in a microwave (MW) and hot air dryer (HA) for a specified period. Powder blends and tablets were evaluated for physical properties, and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). PLS and ANOVA were used to compare tablets properties depending on the composition and technology. The experiment is based on a previous one, in which the plant extracts were processed into tablets using a similar method. Therefore, extending the study to include more plants and the robust statistical evaluation and comparison of the products was a procedure to justify the suitability of the presented method for a wide range of liquid plant extracts. As a result, we obtained tablets with excellent physical properties, including a short disintegration and dissolution, which is problematic in tableted extracts.
ER  -

KOSTELANSKÁ, Klára, S. KURHAJEC, Sylvie PAVLOKOVÁ, David VETCHÝ, Jan GAJDZIOK a Aleš FRANC. Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid Dosage Form. \textit{Pharmaceutics}. Basel: MDPI, 2022, roč.~14, č.~2, s.~1-20. ISSN~1999-4923. Dostupné z: https://dx.doi.org/10.3390/pharmaceutics14020248.

Podrobný výpis o publikaci