| KONKOLOVA, Eva, Kateřina KREJČOVÁ, Luděk EYER, Jan HODEK, Michala ZGARBOVÁ, Andrea FOŘTOVÁ, Michael JIRASEK, Filip TEPLY, Paul E. REYES-GUTIERREZ, Daniel RŮŽEK, Jan WEBER a Evzen BOURA. A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases. Molecules. MDPI, 2022, roč. 27, č. 6, s. 1-10. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules27061894. |
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@article{1840637,
author = {Konkolova, Eva and Krejčová, Kateřina and Eyer, Luděk and Hodek, Jan and Zgarbová, Michala and Fořtová, Andrea and Jirasek, Michael and Teply, Filip and ReyesandGutierrez, Paul E. and Růžek, Daniel and Weber, Jan and Boura, Evzen},
article_number = {6},
doi = {http://dx.doi.org/10.3390/molecules27061894},
keywords = {helquat-like compound; RNA-dependent RNA-polymerase; SARS-CoV-2; Flaviruses; antiviral agents},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases},
url = {https://www.mdpi.com/1420-3049/27/6/1894},
volume = {27},
year = {2022}
}
TY - JOUR
ID - 1840637
AU - Konkolova, Eva - Krejčová, Kateřina - Eyer, Luděk - Hodek, Jan - Zgarbová, Michala - Fořtová, Andrea - Jirasek, Michael - Teply, Filip - Reyes-Gutierrez, Paul E. - Růžek, Daniel - Weber, Jan - Boura, Evzen
PY - 2022
TI - A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases
JF - Molecules
VL - 27
IS - 6
SP - 1-10
EP - 1-10
PB - MDPI
SN - 14203049
KW - helquat-like compound
KW - RNA-dependent RNA-polymerase
KW - SARS-CoV-2
KW - Flaviruses
KW - antiviral agents
UR - https://www.mdpi.com/1420-3049/27/6/1894
N2 - Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.
ER -
KONKOLOVA, Eva, Kateřina KREJČOVÁ, Luděk EYER, Jan HODEK, Michala ZGARBOVÁ, Andrea FOŘTOVÁ, Michael JIRASEK, Filip TEPLY, Paul E. REYES-GUTIERREZ, Daniel RŮŽEK, Jan WEBER a Evzen BOURA. A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases. \textit{Molecules}. MDPI, 2022, roč.~27, č.~6, s.~1-10. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules27061894.
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