A Helquat-like Compound as a Potent Inhibitor of Flaviviral and
Coronaviral Polymerases

J 2022

A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases

KONKOLOVA, Eva, Kateřina KREJČOVÁ, Luděk EYER, Jan HODEK, Michala ZGARBOVÁ et. al.

Základní údaje

Originální název

A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases

Autoři

KONKOLOVA, Eva, Kateřina KREJČOVÁ, Luděk EYER (203 Česká republika), Jan HODEK, Michala ZGARBOVÁ, Andrea FOŘTOVÁ (203 Česká republika), Michael JIRASEK, Filip TEPLY, Paul E. REYES-GUTIERREZ, Daniel RŮŽEK (203 Česká republika, domácí), Jan WEBER a Evzen BOURA

Vydání

Molecules, MDPI, 2022, 1420-3049

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10606 Microbiology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600

Kód RIV

RIV/00216224:14310/22:00125511

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/molecules27061894

UT WoS

000774291500001

Klíčová slova anglicky

helquat-like compound; RNA-dependent RNA-polymerase; SARS-CoV-2; Flaviruses; antiviral agents

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 4. 2022 12:45, Mgr. Marie Šípková, DiS.

Anotace

V originále

Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.

Citovat

KONKOLOVA, Eva, Kateřina KREJČOVÁ, Luděk EYER, Jan HODEK, Michala ZGARBOVÁ, Andrea FOŘTOVÁ, Michael JIRASEK, Filip TEPLY, Paul E. REYES-GUTIERREZ, Daniel RŮŽEK, Jan WEBER a Evzen BOURA. A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases. Molecules. MDPI, 2022, roč. 27, č. 6, s. 1-10. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules27061894.

@article{1840637,
   author = {Konkolova, Eva and Krejčová, Kateřina and Eyer, Luděk and Hodek, Jan and Zgarbová, Michala and Fořtová, Andrea and Jirasek, Michael and Teply, Filip and ReyesandGutierrez, Paul E. and Růžek, Daniel and Weber, Jan and Boura, Evzen},
   article_number = {6},
   doi = {http://dx.doi.org/10.3390/molecules27061894},
   keywords = {helquat-like compound; RNA-dependent RNA-polymerase; SARS-CoV-2; Flaviruses; antiviral agents},
   language = {eng},
   issn = {1420-3049},
   journal = {Molecules},
   title = {A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases},
   url = {https://www.mdpi.com/1420-3049/27/6/1894},
   volume = {27},
   year = {2022}
}

TY  - JOUR
ID  - 1840637
AU  - Konkolova, Eva - Krejčová, Kateřina - Eyer, Luděk - Hodek, Jan - Zgarbová, Michala - Fořtová, Andrea - Jirasek, Michael - Teply, Filip - Reyes-Gutierrez, Paul E. - Růžek, Daniel - Weber, Jan - Boura, Evzen
PY  - 2022
TI  - A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases
JF  - Molecules
VL  - 27
IS  - 6
SP  - 1-10
EP  - 1-10
PB  - MDPI
SN  - 14203049
KW  - helquat-like compound
KW  - RNA-dependent RNA-polymerase
KW  - SARS-CoV-2
KW  - Flaviruses
KW  - antiviral agents
UR  - https://www.mdpi.com/1420-3049/27/6/1894
N2  - Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.
ER  -

KONKOLOVA, Eva, Kateřina KREJČOVÁ, Luděk EYER, Jan HODEK, Michala ZGARBOVÁ, Andrea FOŘTOVÁ, Michael JIRASEK, Filip TEPLY, Paul E. REYES-GUTIERREZ, Daniel RŮŽEK, Jan WEBER a Evzen BOURA. A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases. \textit{Molecules}. MDPI, 2022, roč.~27, č.~6, s.~1-10. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules27061894.

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