KONKOLOVA, Eva, Kateřina KREJČOVÁ, Luděk EYER, Jan HODEK, Michala ZGARBOVÁ, Andrea FOŘTOVÁ, Michael JIRASEK, Filip TEPLY, Paul E. REYES-GUTIERREZ, Daniel RŮŽEK, Jan WEBER a Evzen BOURA. A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases. Molecules. MDPI, 2022, roč. 27, č. 6, s. 1-10. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules27061894. |
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@article{1840637, author = {Konkolova, Eva and Krejčová, Kateřina and Eyer, Luděk and Hodek, Jan and Zgarbová, Michala and Fořtová, Andrea and Jirasek, Michael and Teply, Filip and ReyesandGutierrez, Paul E. and Růžek, Daniel and Weber, Jan and Boura, Evzen}, article_number = {6}, doi = {http://dx.doi.org/10.3390/molecules27061894}, keywords = {helquat-like compound; RNA-dependent RNA-polymerase; SARS-CoV-2; Flaviruses; antiviral agents}, language = {eng}, issn = {1420-3049}, journal = {Molecules}, title = {A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases}, url = {https://www.mdpi.com/1420-3049/27/6/1894}, volume = {27}, year = {2022} }
TY - JOUR ID - 1840637 AU - Konkolova, Eva - Krejčová, Kateřina - Eyer, Luděk - Hodek, Jan - Zgarbová, Michala - Fořtová, Andrea - Jirasek, Michael - Teply, Filip - Reyes-Gutierrez, Paul E. - Růžek, Daniel - Weber, Jan - Boura, Evzen PY - 2022 TI - A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases JF - Molecules VL - 27 IS - 6 SP - 1-10 EP - 1-10 PB - MDPI SN - 14203049 KW - helquat-like compound KW - RNA-dependent RNA-polymerase KW - SARS-CoV-2 KW - Flaviruses KW - antiviral agents UR - https://www.mdpi.com/1420-3049/27/6/1894 N2 - Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible. ER -
KONKOLOVA, Eva, Kateřina KREJČOVÁ, Luděk EYER, Jan HODEK, Michala ZGARBOVÁ, Andrea FOŘTOVÁ, Michael JIRASEK, Filip TEPLY, Paul E. REYES-GUTIERREZ, Daniel RŮŽEK, Jan WEBER a Evzen BOURA. A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases. \textit{Molecules}. MDPI, 2022, roč.~27, č.~6, s.~1-10. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules27061894.
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