Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP

J 2021

Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP

WUNNAVA, Sreekar; Christina F. DIRSCHERL; Jakub VÝRAVSKÝ; Aleš KOVAŘÍK; Roman MATYÁŠEK et. al.

Základní údaje

Originální název

Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP

Autoři

WUNNAVA, Sreekar; Christina F. DIRSCHERL; Jakub VÝRAVSKÝ; Aleš KOVAŘÍK; Roman MATYÁŠEK; Jiří ŠPONER; Dieter BRAUN a Judit E. ŠPONER

Vydání

Chemistry - A European Journal, Wiley, 2021, 0947-6539

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10500 1.5. Earth and related environmental sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.020

Kód RIV

RIV/00216224:14310/21:00124432

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1002/chem.202103672

UT WoS

000721412200001

EID Scopus

2-s2.0-85119690173

Klíčová slova anglicky

cGMP; nonenzymatic polymerization; nucleotides; prebiotic chemistry

Štítky

14315010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 3. 2022 09:29, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

The assembly of ancient informational polymers from nucleotide precursors is the central challenge of life's origin on our planet. Among the possible solutions, dry polymerization of 3’,5’-cyclic guanosine monophosphate (3’,5’-cGMP) has been proposed as a candidate to create oligonucleotides of 15–20 units in length. However, the reported sensitivity of the reaction to the presence of cations raised questions of whether this chemistry could be relevant in a geological context. The experiments in this study show that the presence of cations is not restrictive as long as the reaction is conducted in an acidic environment, in contrast to previous reports that suggested optimal conditions at pH 9.

Citovat

WUNNAVA, Sreekar; Christina F. DIRSCHERL; Jakub VÝRAVSKÝ; Aleš KOVAŘÍK; Roman MATYÁŠEK; Jiří ŠPONER; Dieter BRAUN a Judit E. ŠPONER. Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP. Chemistry - A European Journal. Wiley, 2021, roč. 27, č. 70, s. 17581-17585. ISSN 0947-6539. Dostupné z: https://doi.org/10.1002/chem.202103672.

@article{1842557,
   author = {Wunnava, Sreekar and Dirscherl, Christina F. and Výravský, Jakub and Kovařík, Aleš and Matyášek, Roman and Šponer, Jiří and Braun, Dieter and Šponer, Judit E.},
   article_number = {70},
   doi = {https://doi.org/10.1002/chem.202103672},
   keywords = {cGMP; nonenzymatic polymerization; nucleotides; prebiotic chemistry},
   language = {eng},
   issn = {0947-6539},
   journal = {Chemistry - A European Journal},
   title = {Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP},
   url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202103672},
   volume = {27},
   year = {2021}
}

TY  - JOUR
ID  - 1842557
AU  - Wunnava, Sreekar - Dirscherl, Christina F. - Výravský, Jakub - Kovařík, Aleš - Matyášek, Roman - Šponer, Jiří - Braun, Dieter - Šponer, Judit E.
PY  - 2021
TI  - Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP
JF  - Chemistry - A European Journal
VL  - 27
IS  - 70
SP  - 17581-17585
EP  - 17581-17585
PB  - Wiley
SN  - 09476539
KW  - cGMP
KW  - nonenzymatic polymerization
KW  - nucleotides
KW  - prebiotic chemistry
UR  - https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202103672
N2  - The assembly of ancient informational polymers from nucleotide precursors is the central challenge of life's origin on our planet. Among the possible solutions, dry polymerization of 3’,5’-cyclic guanosine monophosphate (3’,5’-cGMP) has been proposed as a candidate to create oligonucleotides of 15–20 units in length. However, the reported sensitivity of the reaction to the presence of cations raised questions of whether this chemistry could be relevant in a geological context. The experiments in this study show that the presence of cations is not restrictive as long as the reaction is conducted in an acidic environment, in contrast to previous reports that suggested optimal conditions at pH 9.
ER  -

WUNNAVA, Sreekar; Christina F. DIRSCHERL; Jakub VÝRAVSKÝ; Aleš KOVAŘÍK; Roman MATYÁŠEK; Jiří ŠPONER; Dieter BRAUN a Judit E. ŠPONER. Acid-Catalyzed RNA-Oligomerization from 3',5'-cGMP. \textit{Chemistry - A European Journal}. Wiley, 2021, roč.~27, č.~70, s.~17581-17585. ISSN~0947-6539. Dostupné z: https://doi.org/10.1002/chem.202103672.

Přehled o publikaci