Socioeconomic deprivation in early life and symptoms of
depression and anxiety in young adulthood: Mediating role of
hippocampal connectivity

J 2022

Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity

ČERMÁKOVÁ, P., Lenka ANDRÝSKOVÁ, Milan BRÁZDIL a Klára MAREČKOVÁ

Základní údaje

Originální název

Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity

Autoři

ČERMÁKOVÁ, P., Lenka ANDRÝSKOVÁ (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí) a Klára MAREČKOVÁ (203 Česká republika, garant, domácí)

Vydání

Psychological Medicine, Velká Británie, Cambridge University Press, 2022, 0033-2917

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.900

Kód RIV

RIV/00216224:14740/22:00125564

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1017/S0033291720004754

UT WoS

000880310400031

Klíčová slova anglicky

anxiety; depression; fMRI; sex differences

Štítky

CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 10. 2024 11:48, Ing. Jana Kuchtová

Anotace

V originále

Background Experience of early-life socioeconomic deprivation (ELSD) may increase the risk of mental disorders in young adulthood. This association may be mediated by structural and functional alterations of the hippocampus. Methods We conducted a prospective cohort study on 122 participants of the European Longitudinal Study of Pregnancy and Childhood. Information about ELSD was collected via questionnaire from mothers during the first 18 months of participants' lives. At age 23-24, participants underwent examination by structural magnetic resonance imaging, resting-state functional connectivity and assessment of depressive symptoms (Mood and Feelings Questionnaire) and anxiety (Spielberger State-Trait Anxiety Inventory). The association of ELSD with brain outcomes in young adulthood was assessed with correlations, linear regression (adjusting for sex, socioeconomic position and mother's mental health) and moderated mediation analysis. Results Higher ELSD was associated with greater depressive symptoms (B = 0.22; p = 0.001), trait anxiety (B = 0.07; p = 0.02) and lower global connectivity of the right hippocampus (B =-0.01; p = 0.02). These associations persisted when adjusted for covariates. In women, lower global connectivity of the right hippocampus was associated with stronger trait anxiety (B =-4.14; p = 0.01). Global connectivity of the right hippocampus as well as connectivity between the right hippocampus and the left middle temporal gyrus mediated the association between ELSD and trait anxiety in women. Higher ELSD correlated with a lower volume of the right hippocampus in men, but the volume of the right hippocampus was not related to mental health. Conclusions Early preventive strategies targeted at children from socioeconomically deprived families may yield long-lasting benefits for the mental health of the population. © 2020 The Author(s). Published by Cambridge University Press.

Návaznosti

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

ČERMÁKOVÁ, P., Lenka ANDRÝSKOVÁ, Milan BRÁZDIL a Klára MAREČKOVÁ. Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity. Psychological Medicine. Velká Británie: Cambridge University Press, 2022, roč. 52, č. 13, s. 2671-2680. ISSN 0033-2917. Dostupné z: https://dx.doi.org/10.1017/S0033291720004754.

@article{1842657,
   author = {Čermáková, P. and Andrýsková, Lenka and Brázdil, Milan and Marečková, Klára},
   article_location = {Velká Británie},
   article_number = {13},
   doi = {http://dx.doi.org/10.1017/S0033291720004754},
   keywords = {anxiety; depression; fMRI; sex differences},
   language = {eng},
   issn = {0033-2917},
   journal = {Psychological Medicine},
   title = {Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity},
   url = {https://www.cambridge.org/core/journals/psychological-medicine/article/socioeconomic-deprivation-in-early-life-and-symptoms-of-depression-and-anxiety-in-young-adulthood-mediating-role-of-hippocampal-connectivity/389D84B5689593935017EA38FA905E44},
   volume = {52},
   year = {2022}
}

TY  - JOUR
ID  - 1842657
AU  - Čermáková, P. - Andrýsková, Lenka - Brázdil, Milan - Marečková, Klára
PY  - 2022
TI  - Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity
JF  - Psychological Medicine
VL  - 52
IS  - 13
SP  - 2671-2680
EP  - 2671-2680
PB  - Cambridge University Press
SN  - 00332917
KW  - anxiety
KW  - depression
KW  - fMRI
KW  - sex differences
UR  - https://www.cambridge.org/core/journals/psychological-medicine/article/socioeconomic-deprivation-in-early-life-and-symptoms-of-depression-and-anxiety-in-young-adulthood-mediating-role-of-hippocampal-connectivity/389D84B5689593935017EA38FA905E44
N2  - Background Experience of early-life socioeconomic deprivation (ELSD) may increase the risk of mental disorders in young adulthood. This association may be mediated by structural and functional alterations of the hippocampus. Methods We conducted a prospective cohort study on 122 participants of the European Longitudinal Study of Pregnancy and Childhood. Information about ELSD was collected via questionnaire from mothers during the first 18 months of participants' lives. At age 23-24, participants underwent examination by structural magnetic resonance imaging, resting-state functional connectivity and assessment of depressive symptoms (Mood and Feelings Questionnaire) and anxiety (Spielberger State-Trait Anxiety Inventory). The association of ELSD with brain outcomes in young adulthood was assessed with correlations, linear regression (adjusting for sex, socioeconomic position and mother's mental health) and moderated mediation analysis. Results Higher ELSD was associated with greater depressive symptoms (B = 0.22; p = 0.001), trait anxiety (B = 0.07; p = 0.02) and lower global connectivity of the right hippocampus (B =-0.01; p = 0.02). These associations persisted when adjusted for covariates. In women, lower global connectivity of the right hippocampus was associated with stronger trait anxiety (B =-4.14; p = 0.01). Global connectivity of the right hippocampus as well as connectivity between the right hippocampus and the left middle temporal gyrus mediated the association between ELSD and trait anxiety in women. Higher ELSD correlated with a lower volume of the right hippocampus in men, but the volume of the right hippocampus was not related to mental health. Conclusions Early preventive strategies targeted at children from socioeconomically deprived families may yield long-lasting benefits for the mental health of the population. © 2020 The Author(s). Published by Cambridge University Press.
ER  -

ČERMÁKOVÁ, P., Lenka ANDRÝSKOVÁ, Milan BRÁZDIL a Klára MAREČKOVÁ. Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: Mediating role of hippocampal connectivity. \textit{Psychological Medicine}. Velká Británie: Cambridge University Press, 2022, roč.~52, č.~13, s.~2671-2680. ISSN~0033-2917. Dostupné z: https://dx.doi.org/10.1017/S0033291720004754.

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