NiO Nanoparticles for Electrochemical Insulin Detection

J 2021

NiO Nanoparticles for Electrochemical Insulin Detection

SHEPA, Jana; Ivana ŠIŠOLÁKOVÁ; Marek VOJTKO; Libuše TRNKOVÁ; Géza NAGY et al.

Základní údaje

Originální název

NiO Nanoparticles for Electrochemical Insulin Detection

Autoři

SHEPA, Jana; Ivana ŠIŠOLÁKOVÁ; Marek VOJTKO; Libuše TRNKOVÁ; Géza NAGY; Iveta MASKAĽOVÁ; Andrej ORIŇAK a Renáta ORIŇAKOVÁ

Vydání

Sensors, MDPI, 2021, 1424-8220

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10405 Electrochemistry

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.847

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/21:00124465

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

NiO nanoparticles; insulin; electrochemical sensor

Štítky

14313010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 3. 2022 08:50, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Diabetes mellitus represents one of the most widespread diseases in civilization nowadays. Since the costs for treating and diagnosing of diabetes represent several billions of dollars per year, a cheap, fast, and simple sensor for diabetes diagnosis is needed. Electrochemical insulin sensors can be considered as a novel approach for diabetes diagnosis. In this study, carbon electrode with electrodeposited NiO nanoparticles was selected as a suitable electrode material for insulin determination. The morphology and surface composition were studied by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and X-ray photoelectron spectroscopy (XPS). For a better understanding of insulin determination on NiO-modified electrodes, the mechanism of electrochemical reaction and the kinetic parameters were studied. They were calculated from both voltammetric and amperometric measurements. The modified carbon electrode displayed a wide linear range from 600 nM to 10 µM, a low limit of detection of 19.6 nM, and a high sensitivity of 7.06 µA/µM. The electrodes were stable for 30 cycles and were able to detect insulin even in bovine blood serum. Additionally, the temperature stability of this electrode and its storage conditions were studied with appropriate outcomes. The above results show the high promise of this electrode for detecting insulin in clinical samples.

Návaznosti

90110, velká výzkumná infrastruktura

Název: CzechNanoLab

Citovat

SHEPA, Jana; Ivana ŠIŠOLÁKOVÁ; Marek VOJTKO; Libuše TRNKOVÁ; Géza NAGY; Iveta MASKAĽOVÁ; Andrej ORIŇAK a Renáta ORIŇAKOVÁ. NiO Nanoparticles for Electrochemical Insulin Detection. Sensors. MDPI, 2021, roč. 21, č. 15, s. 1-16. ISSN 1424-8220. Dostupné z: https://doi.org/10.3390/s21155063.

@article{1843477,
   author = {Shepa, Jana and Šišoláková, Ivana and Vojtko, Marek and Trnková, Libuše and Nagy, Géza and Maskaľová, Iveta and Oriňak, Andrej and Oriňaková, Renáta},
   article_number = {15},
   doi = {https://doi.org/10.3390/s21155063},
   keywords = {NiO nanoparticles; insulin; electrochemical sensor},
   language = {eng},
   issn = {1424-8220},
   journal = {Sensors},
   title = {NiO Nanoparticles for Electrochemical Insulin Detection},
   url = {https://www.mdpi.com/1424-8220/21/15/5063},
   volume = {21},
   year = {2021}
}

TY  - JOUR
ID  - 1843477
AU  - Shepa, Jana - Šišoláková, Ivana - Vojtko, Marek - Trnková, Libuše - Nagy, Géza - Maskaľová, Iveta - Oriňak, Andrej - Oriňaková, Renáta
PY  - 2021
TI  - NiO Nanoparticles for Electrochemical Insulin Detection
JF  - Sensors
VL  - 21
IS  - 15
SP  - 1-16
EP  - 1-16
PB  - MDPI
SN  - 14248220
KW  - NiO nanoparticles
KW  - insulin
KW  - electrochemical sensor
UR  - https://www.mdpi.com/1424-8220/21/15/5063
N2  - Diabetes mellitus represents one of the most widespread diseases in civilization nowadays. Since the costs for treating and diagnosing of diabetes represent several billions of dollars per year, a cheap, fast, and simple sensor for diabetes diagnosis is needed. Electrochemical insulin sensors can be considered as a novel approach for diabetes diagnosis. In this study, carbon electrode with electrodeposited NiO nanoparticles was selected as a suitable electrode material for insulin determination. The morphology and surface composition were studied by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and X-ray photoelectron spectroscopy (XPS). For a better understanding of insulin determination on NiO-modified electrodes, the mechanism of electrochemical reaction and the kinetic parameters were studied. They were calculated from both voltammetric and amperometric measurements. The modified carbon electrode displayed a wide linear range from 600 nM to 10 µM, a low limit of detection of 19.6 nM, and a high sensitivity of 7.06 µA/µM. The electrodes were stable for 30 cycles and were able to detect insulin even in bovine blood serum. Additionally, the temperature stability of this electrode and its storage conditions were studied with appropriate outcomes. The above results show the high promise of this electrode for detecting insulin in clinical samples.
ER  -

SHEPA, Jana; Ivana ŠIŠOLÁKOVÁ; Marek VOJTKO; Libuše TRNKOVÁ; Géza NAGY; Iveta MASKAĽOVÁ; Andrej ORIŇAK a Renáta ORIŇAKOVÁ. NiO Nanoparticles for Electrochemical Insulin Detection. \textit{Sensors}. MDPI, 2021, roč.~21, č.~15, s.~1-16. ISSN~1424-8220. Dostupné z: https://doi.org/10.3390/s21155063.

Přehled o publikaci