Local Wnt signalling in the asymmetric migrating vertebrate
cells

J 2022

Local Wnt signalling in the asymmetric migrating vertebrate cells

ČADA, Štěpán a Vítězslav BRYJA

Základní údaje

Originální název

Local Wnt signalling in the asymmetric migrating vertebrate cells

Autoři

ČADA, Štěpán a Vítězslav BRYJA

Vydání

Seminars in Cell & Developmental Biology, Elsevier Ltd, 2022, 1084-9521

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.300

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00125589

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Wnt; Planar cell polarity; Cell migration; Axon guidance; Vangl; neural crest cell migration; amoeboid migration

Štítky

14314010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 5. 2022 11:33, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Wnt signalling is known to generate cellular asymmetry via Wnt/planar cell polarity pathway (Wnt/PCP). Wnt/PCP acts locally (i) to orient membrane polarity and asymmetric establishment of intercellular junctions via conserved set of PCP proteins most specifically represented by Vangl and Prickle, and (ii) to asymmetrically rearrange cytoskeletal structures via downstream effectors of Dishevelled (Dvl). This process is best described on stable phenotypes of epithelial cells. Here, however, we review the activity of Wnt signalling in migratory cells which experience the extensive rearrangements of cytoskeleton and consequently dynamic asymmetry, making the localised effects of Wnt signalling easier to distinguish. Firstly, we focused on migration of neuronal axons, which allows to study how the pre-existent cellular asymmetry can influence Wnt signalling outcome. Then, we reviewed the role of Wnt signalling in models of mesenchymal migration including neural crest, melanoma, and breast cancer cells. Last, we collected evidence for local Wnt signalling in amoeboid cells, especially lymphocytes. As the outcome of this review, we identify blank spots in our current understanding of this topic, propose models that synthesise the current observations and allow formulation of testable hypotheses for the future research.

Návaznosti

GX19-28347X, projekt VaV

Název: Molekulární a funkční analýza biologie kasein kinázy 1

Investor: Grantová agentura ČR, Molekulární a funkční analýza biologie kasein kinázy 1

Citovat

ČADA, Štěpán a Vítězslav BRYJA. Local Wnt signalling in the asymmetric migrating vertebrate cells. Seminars in Cell & Developmental Biology. Elsevier Ltd, 2022, roč. 125, May, s. 26-36. ISSN 1084-9521. Dostupné z: https://doi.org/10.1016/j.semcdb.2021.11.020.

@article{1843558,
   author = {Čada, Štěpán and Bryja, Vítězslav},
   article_number = {May},
   doi = {https://doi.org/10.1016/j.semcdb.2021.11.020},
   keywords = {Wnt; Planar cell polarity; Cell migration; Axon guidance; Vangl; neural crest cell migration; amoeboid migration},
   language = {eng},
   issn = {1084-9521},
   journal = {Seminars in Cell & Developmental Biology},
   title = {Local Wnt signalling in the asymmetric migrating vertebrate cells},
   url = {https://www.sciencedirect.com/science/article/pii/S1084952121003025},
   volume = {125},
   year = {2022}
}

TY  - JOUR
ID  - 1843558
AU  - Čada, Štěpán - Bryja, Vítězslav
PY  - 2022
TI  - Local Wnt signalling in the asymmetric migrating vertebrate cells
JF  - Seminars in Cell & Developmental Biology
VL  - 125
IS  - May
SP  - 26-36
EP  - 26-36
PB  - Elsevier Ltd
SN  - 10849521
KW  - Wnt
KW  - Planar cell polarity
KW  - Cell migration
KW  - Axon guidance
KW  - Vangl
KW  - neural crest cell migration
KW  - amoeboid migration
UR  - https://www.sciencedirect.com/science/article/pii/S1084952121003025
N2  - Wnt signalling is known to generate cellular asymmetry via Wnt/planar cell polarity pathway (Wnt/PCP). Wnt/PCP acts locally (i) to orient membrane polarity and asymmetric establishment of intercellular junctions via conserved set of PCP proteins most specifically represented by Vangl and Prickle, and (ii) to asymmetrically rearrange cytoskeletal structures via downstream effectors of Dishevelled (Dvl). This process is best described on stable phenotypes of epithelial cells. Here, however, we review the activity of Wnt signalling in migratory cells which experience the extensive rearrangements of cytoskeleton and consequently dynamic asymmetry, making the localised effects of Wnt signalling easier to distinguish. Firstly, we focused on migration of neuronal axons, which allows to study how the pre-existent cellular asymmetry can influence Wnt signalling outcome. Then, we reviewed the role of Wnt signalling in models of mesenchymal migration including neural crest, melanoma, and breast cancer cells. Last, we collected evidence for local Wnt signalling in amoeboid cells, especially lymphocytes. As the outcome of this review, we identify blank spots in our current understanding of this topic, propose models that synthesise the current observations and allow formulation of testable hypotheses for the future research.
ER  -

ČADA, Štěpán a Vítězslav BRYJA. Local Wnt signalling in the asymmetric migrating vertebrate cells. \textit{Seminars in Cell \&{} Developmental Biology}. Elsevier Ltd, 2022, roč.~125, May, s.~26-36. ISSN~1084-9521. Dostupné z: https://doi.org/10.1016/j.semcdb.2021.11.020.

Přehled o publikaci