Impact of Prenatal Stress on Amygdala Anatomy in Young
Adulthood: Timing and Location Matter

J 2022

Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter

MAREČKOVÁ, Klára; Radek MAREČEK; Lenka ANDRÝSKOVÁ; Milan BRÁZDIL; Y.S. NIKOLOVA et al.

Základní údaje

Originální název

Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter

Autoři

MAREČKOVÁ, Klára; Radek MAREČEK; Lenka ANDRÝSKOVÁ ; Milan BRÁZDIL a Y.S. NIKOLOVA

Vydání

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2022, 2451-9022

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.900

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/22:00125608

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

MATERNAL DEPRESSIVE SYMPTOMSNEUROBIOLOGICAL CONSEQUENCESFUNCTIONAL CONNECTIVITYBASOLATERAL AMYGDALABRAIN-DEVELOPMENTCORTICAL NUCLEUSHIPPOCAMPUSSYSTEMVOLUMEAGE

Štítky

143180, CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 6. 2025 07:41, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

BACKGROUND: Exposure to maternal stress in utero has long-term implications for the developing brain and has been linked with a higher risk of depression. The amygdala, which develops during the early embryonic stage and is critical for emotion processing, might be particularly sensitive. METHODS: Using data from a neuroimaging follow-up of the European Longitudinal Study of Pregnancy and Childhood prenatal birth cohort (n = 129, 47% men, 23-24 years old), we studied the impact of prenatal stress during the first and second halves of pregnancy on the volume of the amygdala and its nuclei in young adult offspring. We further evaluated the relationship between amygdala anatomy and offspring depressive symptomatology. Amygdala nuclei were parcellated using FreeSurfer's automated segmentation pipeline. Depressive symptoms were measured via self-report using the Beck Depression Inventory. RESULTS: Exposure to stress during the first half of pregnancy was associated with smaller accessory basal (Cohen's f(2) = 0.27, false discovery rate [FDR]-corrected p [pFDR] = .03) and cortical (Cohen's f(2) = 0.29, pFDR = .03) nuclei volumes. This effect remained significant after correcting for sex, stress during the second half of pregnancy, maternal age at birth, birth weight, maternal education, and offspring's age at magnetic resonance imaging. These two nuclei showed a quadratic relationship with Beck Depression Inventory scores in young adulthood, where both smaller and larger volumes were associated with more depressive symptoms (accessory basal nucleus: adj. R-2 = 0.05, pFDR = .015; cortical nucleus: adj. R-2 = 0.04, pFDR = .015). CONCLUSIONS: We conclude that exposure to stress during the first half of pregnancy might have long-term implications for amygdala anatomy, which may in turn predict the experience of depressive symptoms in young adulthood.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NU20J-04-00022, projekt VaV

Název: Zdravé stárnutí mozku: Celoživotní perspektiva

Investor: Ministerstvo zdravotnictví ČR, Zdravé stárnutí mozku: Celoživotní perspektiva, Podprogram 2 - juniorský - výzkumníci do 35 let

90121, velká výzkumná infrastruktura

Název: RECETOX RI

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

MAREČKOVÁ, Klára; Radek MAREČEK; Lenka ANDRÝSKOVÁ; Milan BRÁZDIL a Y.S. NIKOLOVA. Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter. BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING. 2022, roč. 7, č. 2, s. 231-238. ISSN 2451-9022. Dostupné z: https://doi.org/10.1016/j.bpsc.2021.07.009.

@article{1844917,
   author = {Marečková, Klára and Mareček, Radek and Andrýsková, Lenka and Brázdil, Milan and Nikolova, Y.S.},
   article_number = {2},
   doi = {https://doi.org/10.1016/j.bpsc.2021.07.009},
   keywords = {MATERNAL DEPRESSIVE SYMPTOMSNEUROBIOLOGICAL CONSEQUENCESFUNCTIONAL CONNECTIVITYBASOLATERAL AMYGDALABRAIN-DEVELOPMENTCORTICAL NUCLEUSHIPPOCAMPUSSYSTEMVOLUMEAGE},
   language = {eng},
   issn = {2451-9022},
   journal = {BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING},
   title = {Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter},
   url = {https://www.sciencedirect.com/science/article/pii/S2451902221002032?via%3Dihub},
   volume = {7},
   year = {2022}
}

TY  - JOUR
ID  - 1844917
AU  - Marečková, Klára - Mareček, Radek - Andrýsková, Lenka - Brázdil, Milan - Nikolova, Y.S.
PY  - 2022
TI  - Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter
JF  - BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
VL  - 7
IS  - 2
SP  - 231-238
EP  - 231-238
SN  - 24519022
KW  - MATERNAL DEPRESSIVE SYMPTOMSNEUROBIOLOGICAL CONSEQUENCESFUNCTIONAL CONNECTIVITYBASOLATERAL AMYGDALABRAIN-DEVELOPMENTCORTICAL NUCLEUSHIPPOCAMPUSSYSTEMVOLUMEAGE
UR  - https://www.sciencedirect.com/science/article/pii/S2451902221002032?via%3Dihub
N2  - BACKGROUND: Exposure to maternal stress in utero has long-term implications for the developing brain and has been linked with a higher risk of depression. The amygdala, which develops during the early embryonic stage and is critical for emotion processing, might be particularly sensitive. METHODS: Using data from a neuroimaging follow-up of the European Longitudinal Study of Pregnancy and Childhood prenatal birth cohort (n = 129, 47% men, 23-24 years old), we studied the impact of prenatal stress during the first and second halves of pregnancy on the volume of the amygdala and its nuclei in young adult offspring. We further evaluated the relationship between amygdala anatomy and offspring depressive symptomatology. Amygdala nuclei were parcellated using FreeSurfer's automated segmentation pipeline. Depressive symptoms were measured via self-report using the Beck Depression Inventory. RESULTS: Exposure to stress during the first half of pregnancy was associated with smaller accessory basal (Cohen's f(2) = 0.27, false discovery rate [FDR]-corrected p [pFDR] = .03) and cortical (Cohen's f(2) = 0.29, pFDR = .03) nuclei volumes. This effect remained significant after correcting for sex, stress during the second half of pregnancy, maternal age at birth, birth weight, maternal education, and offspring's age at magnetic resonance imaging. These two nuclei showed a quadratic relationship with Beck Depression Inventory scores in young adulthood, where both smaller and larger volumes were associated with more depressive symptoms (accessory basal nucleus: adj. R-2 = 0.05, pFDR = .015; cortical nucleus: adj. R-2 = 0.04, pFDR = .015). CONCLUSIONS: We conclude that exposure to stress during the first half of pregnancy might have long-term implications for amygdala anatomy, which may in turn predict the experience of depressive symptoms in young adulthood.
ER  -

MAREČKOVÁ, Klára; Radek MAREČEK; Lenka ANDRÝSKOVÁ; Milan BRÁZDIL a Y.S. NIKOLOVA. Impact of Prenatal Stress on Amygdala Anatomy in Young Adulthood: Timing and Location Matter. \textit{BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING}. 2022, roč.~7, č.~2, s.~231-238. ISSN~2451-9022. Dostupné z: https://doi.org/10.1016/j.bpsc.2021.07.009.

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