The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters

VASILEIOU, K., Jakub VYSLOUŽIL, Miroslava PAVELKOVÁ a Kateřina KUBOVÁ. The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters. Ceska a Slovenska Farmacie. Czech Medical Association J.E. Purkyn, 2017, roč. 66, č. 5, s. 274 - 280. ISSN 1210-7816.

Základní údaje

• Originální název: The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters
• Autoři: VASILEIOU, K., Jakub VYSLOUŽIL, Miroslava PAVELKOVÁ a Kateřina KUBOVÁ.
• Vydání: Ceska a Slovenska Farmacie, Czech Medical Association J.E. Purkyn, 2017, 1210-7816.

Další údaje

• Typ výsledku: Článek v odborném periodiku
• Utajení: není předmětem státního či obchodního tajemství
• Organizační jednotka: Přírodovědecká fakulta
• Klíčová slova česky: Eudragit RS®; Microparticles; Solvent evaporation; Sustained drug release

Anotace

Size-reduced microparticles were successfully obtained by solvent evaporation method. Different parameters were applied in each sample and their influence on microparticles was evaluated. As a model drug the insoluble ibuprofen was selected for the encapsulation process with Eudragit® RS. The obtained microparticles were inspected by optical microscopy and scanning electron microscopy. The effect of aqueous phase volume (600, 400, 200 ml) and the concentration of polyvinyl alcohol (PVA; 1.0% and 0.1%) were studied. It was evaluated how those variations and also size can affect microparticle characteristics such as encapsulation efficiency, drug loading, burst effect and microparticle morphology. It was observed that the sample prepared with 600 ml aqueous phase and 1% concentration of polyvinyl alcohol gave the most favorable results.