The size-reduced Eudragit® RS microparticles prepared by
solvent evaporation method – Monitoring the effect of selected
variables on tested parameters

J 2017

The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters

VASILEIOU, K.; Jakub VYSLOUŽIL; Miroslava PAVELKOVÁ a Kateřina KUBOVÁ

Základní údaje

Originální název

The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters

Autoři

VASILEIOU, K.; Jakub VYSLOUŽIL ; Miroslava PAVELKOVÁ a Kateřina KUBOVÁ

Vydání

Ceska a Slovenska Farmacie, Czech Medical Association J.E. Purkyn, 2017, 1210-7816

Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Přírodovědecká fakulta

EID Scopus

2-s2.0-85045441407

Klíčová slova česky

Eudragit RS®; Microparticles; Solvent evaporation; Sustained drug release

Změněno: 5. 5. 2022 17:45, JUDr. Sabina Gajdzioková

Anotace

V originále

Size-reduced microparticles were successfully obtained by solvent evaporation method. Different parameters were applied in each sample and their influence on microparticles was evaluated. As a model drug the insoluble ibuprofen was selected for the encapsulation process with Eudragit® RS. The obtained microparticles were inspected by optical microscopy and scanning electron microscopy. The effect of aqueous phase volume (600, 400, 200 ml) and the concentration of polyvinyl alcohol (PVA; 1.0% and 0.1%) were studied. It was evaluated how those variations and also size can affect microparticle characteristics such as encapsulation efficiency, drug loading, burst effect and microparticle morphology. It was observed that the sample prepared with 600 ml aqueous phase and 1% concentration of polyvinyl alcohol gave the most favorable results.

Citovat

VASILEIOU, K.; Jakub VYSLOUŽIL; Miroslava PAVELKOVÁ a Kateřina KUBOVÁ. The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters. Ceska a Slovenska Farmacie. Czech Medical Association J.E. Purkyn, 2017, roč. 66, č. 5, s. 274 - 280. ISSN 1210-7816.

@article{1851257,
   author = {Vasileiou, K. and Vysloužil, Jakub and Pavelková, Miroslava and Kubová, Kateřina},
   article_number = {5},
   issn = {1210-7816},
   journal = {Ceska a Slovenska Farmacie},
   title = {The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters},
   volume = {66},
   year = {2017}
}

TY  - JOUR
ID  - 1851257
AU  - Vasileiou, K. - Vysloužil, Jakub - Pavelková, Miroslava - Kubová, Kateřina
PY  - 2017
TI  - The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters
JF  - Ceska a Slovenska Farmacie
VL  - 66
IS  - 5
SP  - 274 - 280
EP  - 274 - 280
PB  - Czech Medical Association J.E. Purkyn
SN  - 12107816
N2  - Size-reduced microparticles were successfully obtained by solvent evaporation method. Different parameters were applied in each sample and their influence on microparticles was evaluated. As a model drug the insoluble ibuprofen was selected for the encapsulation process with Eudragit® RS. The obtained microparticles were inspected by optical microscopy and scanning electron microscopy. The effect of aqueous phase volume (600, 400, 200 ml) and the concentration of polyvinyl alcohol (PVA; 1.0% and 0.1%) were studied. It was evaluated how those variations and also size can affect microparticle characteristics such as encapsulation efficiency, drug loading, burst effect and microparticle morphology. It was observed that the sample prepared with 600 ml aqueous phase and 1% concentration of polyvinyl alcohol gave the most favorable results.
ER  -

VASILEIOU, K.; Jakub VYSLOUŽIL; Miroslava PAVELKOVÁ a Kateřina KUBOVÁ. The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters. \textit{Ceska a Slovenska Farmacie}. Czech Medical Association J.E. Purkyn, 2017, roč.~66, č.~5, s.~274 - 280. ISSN~1210-7816.

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