VASILEIOU, K., Jakub VYSLOUŽIL, Miroslava PAVELKOVÁ a Kateřina KUBOVÁ. The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters. Ceska a Slovenska Farmacie. Czech Medical Association J.E. Purkyn, 2017, roč. 66, č. 5, s. 274 - 280. ISSN 1210-7816. |
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@article{1851257, author = {Vasileiou, K. and Vysloužil, Jakub and Pavelková, Miroslava and Kubová, Kateřina}, article_number = {5}, issn = {1210-7816}, journal = {Ceska a Slovenska Farmacie}, title = {The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters}, volume = {66}, year = {2017} }
TY - JOUR ID - 1851257 AU - Vasileiou, K. - Vysloužil, Jakub - Pavelková, Miroslava - Kubová, Kateřina PY - 2017 TI - The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters JF - Ceska a Slovenska Farmacie VL - 66 IS - 5 SP - 274 - 280 EP - 274 - 280 PB - Czech Medical Association J.E. Purkyn SN - 12107816 N2 - Size-reduced microparticles were successfully obtained by solvent evaporation method. Different parameters were applied in each sample and their influence on microparticles was evaluated. As a model drug the insoluble ibuprofen was selected for the encapsulation process with Eudragit® RS. The obtained microparticles were inspected by optical microscopy and scanning electron microscopy. The effect of aqueous phase volume (600, 400, 200 ml) and the concentration of polyvinyl alcohol (PVA; 1.0% and 0.1%) were studied. It was evaluated how those variations and also size can affect microparticle characteristics such as encapsulation efficiency, drug loading, burst effect and microparticle morphology. It was observed that the sample prepared with 600 ml aqueous phase and 1% concentration of polyvinyl alcohol gave the most favorable results. ER -
VASILEIOU, K., Jakub VYSLOUŽIL, Miroslava PAVELKOVÁ a Kateřina KUBOVÁ. The size-reduced Eudragit® RS microparticles prepared by solvent evaporation method – Monitoring the effect of selected variables on tested parameters. \textit{Ceska a Slovenska Farmacie}. Czech Medical Association J.E. Purkyn, 2017, roč.~66, č.~5, s.~274 - 280. ISSN~1210-7816.
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