Formulation and Evaluation of Novel Film Wound Dressing Based
on Collagen/Microfibrillated Carboxymethylcellulose Blend

J 2022

Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend

TENOROVÁ, Kateřina; Ruta MASTEIKOVÁ; Sylvie PAVLOKOVÁ; Klára KOSTELANSKÁ; J. BERNATONIENE et al.

Základní údaje

Originální název

Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend

Autoři

TENOROVÁ, Kateřina ; Ruta MASTEIKOVÁ; Sylvie PAVLOKOVÁ ; Klára KOSTELANSKÁ; J. BERNATONIENE a David VETCHÝ

Vydání

Pharmaceutics, Basel, MDPI, 2022, 1999-4923

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.400

Kód RIV

RIV/00216224:14160/22:00125797

Organizační jednotka

Farmaceutická fakulta

DOI

https://doi.org/10.3390/pharmaceutics14040782

UT WoS

000786850200001

EID Scopus

2-s2.0-85128475091

Klíčová slova anglicky

film wound dressing; collagen; microfibrillated carboxymethylcellulose; wound healing; blend films; solvent casting method

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 5. 2022 12:29, JUDr. Sabina Gajdzioková

Anotace

V originále

Collagen is essential as a physiological material in wound healing, so it is often used in wound management, mainly as a lyophilisate. Collagen also has excellent film-forming properties; unfortunately, however, its utilisation as a film wound dressing is limited because of its weak mechanical properties, especially in its wet state. For this reason, modifications or combinations with different materials are investigated. The combination of collagen with partially modified microfibrillar carboxymethylcellulose (CMC), which has not previously been described, provided a new possibility for strengthening collagen films and was the aim of this work. The collagen–CMC films based on three types of collagens, two plasticizers and two collagen. Plasticiser ratios were prepared using the solvent casting method; partially modified CMC served here as both a film-forming agent and a filler, without compromising the transparency of the films. The presence of microfibrils was confirmed microscopically by SEM. Organoleptic and physicochemical evaluation, especially in terms of practical application on wounds, demonstrated that all the samples had satisfactory properties for this purpose even after wetting. All the films retained acidic pH values even after 24 h, with a maximum of 6.27 ± 0.17, and showed a mild degree of swelling, with a maximum of about 6 after 24 h.

Citovat

TENOROVÁ, Kateřina; Ruta MASTEIKOVÁ; Sylvie PAVLOKOVÁ; Klára KOSTELANSKÁ; J. BERNATONIENE a David VETCHÝ. Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend. Pharmaceutics. Basel: MDPI, 2022, roč. 14, č. 4, s. 1-15. ISSN 1999-4923. Dostupné z: https://doi.org/10.3390/pharmaceutics14040782.

@article{1852539,
   author = {Tenorová, Kateřina and Masteiková, Ruta and Pavloková, Sylvie and Kostelanská, Klára and Bernatoniene, J. and Vetchý, David},
   article_location = {Basel},
   article_number = {4},
   doi = {https://doi.org/10.3390/pharmaceutics14040782},
   keywords = {film wound dressing; collagen; microfibrillated carboxymethylcellulose; wound healing; blend films; solvent casting method},
   language = {eng},
   issn = {1999-4923},
   journal = {Pharmaceutics},
   title = {Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend},
   url = {https://www.mdpi.com/1999-4923/14/4/782},
   volume = {14},
   year = {2022}
}

TY  - JOUR
ID  - 1852539
AU  - Tenorová, Kateřina - Masteiková, Ruta - Pavloková, Sylvie - Kostelanská, Klára - Bernatoniene, J. - Vetchý, David
PY  - 2022
TI  - Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend
JF  - Pharmaceutics
VL  - 14
IS  - 4
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 19994923
KW  - film wound dressing
KW  - collagen
KW  - microfibrillated carboxymethylcellulose
KW  - wound healing
KW  - blend films
KW  - solvent casting method
UR  - https://www.mdpi.com/1999-4923/14/4/782
N2  - Collagen is essential as a physiological material in wound healing, so it is often used in wound management, mainly as a lyophilisate. Collagen also has excellent film-forming properties; unfortunately, however, its utilisation as a film wound dressing is limited because of its weak mechanical properties, especially in its wet state. For this reason, modifications or combinations with different materials are investigated. The combination of collagen with partially modified microfibrillar carboxymethylcellulose (CMC), which has not previously been described, provided a new possibility for strengthening collagen films and was the aim of this work. The collagen–CMC films based on three types of collagens, two plasticizers and two collagen. Plasticiser ratios were prepared using the solvent casting method; partially modified CMC served here as both a film-forming agent and a filler, without compromising the transparency of the films. The presence of microfibrils was confirmed microscopically by SEM. Organoleptic and physicochemical evaluation, especially in terms of practical application on wounds, demonstrated that all the samples had satisfactory properties for this purpose even after wetting. All the films retained acidic pH values even after 24 h, with a maximum of 6.27 ± 0.17, and showed a mild degree of swelling, with a maximum of about 6 after 24 h.
ER  -

TENOROVÁ, Kateřina; Ruta MASTEIKOVÁ; Sylvie PAVLOKOVÁ; Klára KOSTELANSKÁ; J. BERNATONIENE a David VETCHÝ. Formulation and Evaluation of Novel Film Wound Dressing Based on Collagen/Microfibrillated Carboxymethylcellulose Blend. \textit{Pharmaceutics}. Basel: MDPI, 2022, roč.~14, č.~4, s.~1-15. ISSN~1999-4923. Dostupné z: https://doi.org/10.3390/pharmaceutics14040782.

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