Synergistic Effect of Chitosan and Selenium Nanoparticles on
Biodegradation and Antibacterial Properties of Collagenous
Scaffolds Designed for Infected Burn Wounds

J 2020

Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds

DORAZILOVA, Jana; Johana MUCHOVA; Kristyna SMERKOVA; Silvia KOCIOVA; Pavel DIVIS et al.

Základní údaje

Originální název

Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds

Autoři

DORAZILOVA, Jana; Johana MUCHOVA; Kristyna SMERKOVA; Silvia KOCIOVA; Pavel DIVIS; Pavel KOPEL; Radek VESELÝ; Veronika PAVLINAKOVA; Vojtech ADAM a Lucy VOJTOVA

Vydání

Journal of Nanomaterials, London, HINDAWI LTD, 2020, 1687-4110

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

21001 Nano-materials

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.986

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/20:00124598

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

tissue engineering; drug release; freeze-drying; collagen; chitosan; selenium nanoparticles; infected burn injuries; bacteria; Staphylococcus

Štítky

14110711, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 5. 2022 09:52, Mgr. Tereza Miškechová

Anotace

V originále

A highly porous scaffold is a desirable outcome in the field of tissue engineering. The porous structure mediates water-retaining properties that ensure good nutrient transportation as well as creates a suitable environment for cells. In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. The addition of antibacterial agents increased the application potential of the material for infected and chronic wounds. The morphology, swelling, biodegradation, and antibacterial activity of collagen-based scaffolds were characterized systematically to investigate the overall impact of the antibacterial additives. The additives visibly influenced the morphology, water-retaining properties as well as the stability of the materials in the presence of collagenase enzymes. Even at concentrations as low as 5 ppm of SeNPs, modified polymeric scaffolds showed considerable inhibition activity towards Gram-positive bacterial strains such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in a dose-dependent manner.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

DORAZILOVA, Jana; Johana MUCHOVA; Kristyna SMERKOVA; Silvia KOCIOVA; Pavel DIVIS; Pavel KOPEL; Radek VESELÝ; Veronika PAVLINAKOVA; Vojtech ADAM a Lucy VOJTOVA. Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds. Journal of Nanomaterials. London: HINDAWI LTD, 2020, roč. 10, č. 10, s. 1-21. ISSN 1687-4110. Dostupné z: https://doi.org/10.3390/nano10101971.

@article{1853540,
   author = {Dorazilova, Jana and Muchova, Johana and Smerkova, Kristyna and Kociova, Silvia and Divis, Pavel and Kopel, Pavel and Veselý, Radek and Pavlinakova, Veronika and Adam, Vojtech and Vojtova, Lucy},
   article_location = {London},
   article_number = {10},
   doi = {https://doi.org/10.3390/nano10101971},
   keywords = {tissue engineering; drug release; freeze-drying; collagen; chitosan; selenium nanoparticles; infected burn injuries; bacteria; Staphylococcus},
   language = {eng},
   issn = {1687-4110},
   journal = {Journal of Nanomaterials},
   title = {Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds},
   url = {https://www.mdpi.com/2079-4991/10/10/1971},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1853540
AU  - Dorazilova, Jana - Muchova, Johana - Smerkova, Kristyna - Kociova, Silvia - Divis, Pavel - Kopel, Pavel - Veselý, Radek - Pavlinakova, Veronika - Adam, Vojtech - Vojtova, Lucy
PY  - 2020
TI  - Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds
JF  - Journal of Nanomaterials
VL  - 10
IS  - 10
SP  - 1-21
EP  - 1-21
PB  - HINDAWI LTD
SN  - 16874110
KW  - tissue engineering
KW  - drug release
KW  - freeze-drying
KW  - collagen
KW  - chitosan
KW  - selenium nanoparticles
KW  - infected burn injuries
KW  - bacteria
KW  - Staphylococcus
UR  - https://www.mdpi.com/2079-4991/10/10/1971
N2  - A highly porous scaffold is a desirable outcome in the field of tissue engineering. The porous structure mediates water-retaining properties that ensure good nutrient transportation as well as creates a suitable environment for cells. In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. The addition of antibacterial agents increased the application potential of the material for infected and chronic wounds. The morphology, swelling, biodegradation, and antibacterial activity of collagen-based scaffolds were characterized systematically to investigate the overall impact of the antibacterial additives. The additives visibly influenced the morphology, water-retaining properties as well as the stability of the materials in the presence of collagenase enzymes. Even at concentrations as low as 5 ppm of SeNPs, modified polymeric scaffolds showed considerable inhibition activity towards Gram-positive bacterial strains such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in a dose-dependent manner.
ER  -

DORAZILOVA, Jana; Johana MUCHOVA; Kristyna SMERKOVA; Silvia KOCIOVA; Pavel DIVIS; Pavel KOPEL; Radek VESELÝ; Veronika PAVLINAKOVA; Vojtech ADAM a Lucy VOJTOVA. Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds. \textit{Journal of Nanomaterials}. London: HINDAWI LTD, 2020, roč.~10, č.~10, s.~1-21. ISSN~1687-4110. Dostupné z: https://doi.org/10.3390/nano10101971.

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