| DORAZILOVA, Jana, Johana MUCHOVA, Kristyna SMERKOVA, Silvia KOCIOVA, Pavel DIVIS, Pavel KOPEL, Radek VESELÝ, Veronika PAVLINAKOVA, Vojtech ADAM and Lucy VOJTOVA. Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds. Journal of Nanomaterials. London: HINDAWI LTD, 2020, vol. 10, No 10, p. 1-21. ISSN 1687-4110. Available from: https://dx.doi.org/10.3390/nano10101971. |
Other formats:
BibTeX
LaTeX
RIS
@article{1853540,
author = {Dorazilova, Jana and Muchova, Johana and Smerkova, Kristyna and Kociova, Silvia and Divis, Pavel and Kopel, Pavel and Veselý, Radek and Pavlinakova, Veronika and Adam, Vojtech and Vojtova, Lucy},
article_location = {London},
article_number = {10},
doi = {http://dx.doi.org/10.3390/nano10101971},
keywords = {tissue engineering; drug release; freeze-drying; collagen; chitosan; selenium nanoparticles; infected burn injuries; bacteria; Staphylococcus},
language = {eng},
issn = {1687-4110},
journal = {Journal of Nanomaterials},
title = {Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds},
url = {https://www.mdpi.com/2079-4991/10/10/1971},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1853540
AU - Dorazilova, Jana - Muchova, Johana - Smerkova, Kristyna - Kociova, Silvia - Divis, Pavel - Kopel, Pavel - Veselý, Radek - Pavlinakova, Veronika - Adam, Vojtech - Vojtova, Lucy
PY - 2020
TI - Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds
JF - Journal of Nanomaterials
VL - 10
IS - 10
SP - 1-21
EP - 1-21
PB - HINDAWI LTD
SN - 16874110
KW - tissue engineering
KW - drug release
KW - freeze-drying
KW - collagen
KW - chitosan
KW - selenium nanoparticles
KW - infected burn injuries
KW - bacteria
KW - Staphylococcus
UR - https://www.mdpi.com/2079-4991/10/10/1971
N2 - A highly porous scaffold is a desirable outcome in the field of tissue engineering. The porous structure mediates water-retaining properties that ensure good nutrient transportation as well as creates a suitable environment for cells. In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. The addition of antibacterial agents increased the application potential of the material for infected and chronic wounds. The morphology, swelling, biodegradation, and antibacterial activity of collagen-based scaffolds were characterized systematically to investigate the overall impact of the antibacterial additives. The additives visibly influenced the morphology, water-retaining properties as well as the stability of the materials in the presence of collagenase enzymes. Even at concentrations as low as 5 ppm of SeNPs, modified polymeric scaffolds showed considerable inhibition activity towards Gram-positive bacterial strains such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in a dose-dependent manner.
ER -
DORAZILOVA, Jana, Johana MUCHOVA, Kristyna SMERKOVA, Silvia KOCIOVA, Pavel DIVIS, Pavel KOPEL, Radek VESELÝ, Veronika PAVLINAKOVA, Vojtech ADAM and Lucy VOJTOVA. Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds. \textit{Journal of Nanomaterials}. London: HINDAWI LTD, 2020, vol.~10, No~10, p.~1-21. ISSN~1687-4110. Available from: https://dx.doi.org/10.3390/nano10101971.
|
