Preoperative CA125 significantly improves risk stratification
in high-grade endometrial cancer

a 2021

Preoperative CA125 significantly improves risk stratification in high-grade endometrial cancer

LOMBAERS, M; K CORNEL; N VISSER; F AMANT; P BRONSERT et al.

Základní údaje

Originální název

Preoperative CA125 significantly improves risk stratification in high-grade endometrial cancer

Autoři

Vydání

ESGO 2021 Congress, 2021

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

ISSN

Změněno: 16. 5. 2022 13:01, Mgr. Tereza Miškechová

Anotace

V originále

Introduction/Background*Patients with high-grade endometrial carcinoma (EC) have an increased risk of lymph node metastasis (LNM). Preoperative serum CA125 and imaging findings have been incorporated in multiple risk stratification models to predict LNM and advanced disease in EC and are widely used in clinical practice. However, data on their predictive value in high-grade EC are limited. We therefore aim to determine the predictive value of CA125 combined with preoperative computed tomography (CT) imaging in high-grade EC for LNM. Methodology Retrospective multicentre cohort study including patients (n=334) with preoperative high-grade EC and available CA125. Clinical data including imaging results, primary surgical treatment and final International Federation of Gynaecology and Obstetrics (FIGO) stage were recorded. CA125 was considered elevated at >35 IU/L. Result(s)*Patients with high-grade EC (n=334) and elevated CA125 more often presented with advanced FIGO stage (III-IV), 64.2% (95/148) versus 18.8% (35/186) in patients with normal CA125 (p<0.05). For patients with elevated CA125 who underwent surgical staging (n=192), the prevalence of LNM was 56.5% (39/69), compared to 14.6% (18/123) in patients with normal CA125 (p<0.05). For patients with preoperative CT imaging (n=148), LNM were suspected in 18.9% (28/148), but histologically confirmed in 27.7% (41/148) of the patients. Preoperative CA125 and CT findings for LNM in relation to risk of LNM are shown in table 1.

Citovat

LOMBAERS, M; K CORNEL; N VISSER; F AMANT; P BRONSERT; P GEOMINI; GIL-MORENO; D Van HAMONT; J HUVILA; C KRAKSTAD; M KOSKAS; G Mancebo MORENO; X MATIAS-GUIU; B PIJLMAN; C VOS; Vít WEINBERGER; M SNIJDERS; I HALDORSEN; C REIJNEN a J PIJNENBORG. Preoperative CA125 significantly improves risk stratification in high-grade endometrial cancer. In ESGO 2021 Congress. 2021. ISSN 1525-1438.

@proceedings{1853617,
   author = {Lombaers, M and Cornel, K and Visser, N and Amant, F and Bronsert, P and Geomini, P and GilandMoreno, and Hamont, D Van and Huvila, J and Krakstad, C and Koskas, M and Moreno, G Mancebo and MatiasandGuiu, X and Pijlman, B and Vos, C and Weinberger, Vít and Snijders, M and Haldorsen, I and Reijnen, C and Pijnenborg, J},
   booktitle = {ESGO 2021 Congress},
   language = {eng},
   title = {Preoperative CA125 significantly improves risk stratification in high-grade endometrial cancer},
   url = {https://ijgc.bmj.com/content/31/Suppl_3/A97.2},
   year = {2021}
}

TY  - CONF
ID  - 1853617
AU  - Lombaers, M - Cornel, K - Visser, N - Amant, F - Bronsert, P - Geomini, P - Gil-Moreno,
AU  - Hamont, D Van - Huvila, J - Krakstad, C - Koskas, M - Moreno, G Mancebo - Matias-Guiu, X - Pijlman, B - Vos, C - Weinberger, Vít - Snijders, M - Haldorsen, I - Reijnen, C - Pijnenborg, J
PY  - 2021
TI  - Preoperative CA125 significantly improves risk stratification in high-grade endometrial cancer
UR  - https://ijgc.bmj.com/content/31/Suppl_3/A97.2
N2  - Introduction/Background*Patients with high-grade endometrial carcinoma (EC) have an increased risk of lymph node metastasis (LNM). Preoperative serum CA125 and imaging findings have been incorporated in multiple risk stratification models to predict LNM and advanced disease in EC and are widely used in clinical practice. However, data on their predictive value in high-grade EC are limited. We therefore aim to determine the predictive value of CA125 combined with preoperative computed tomography (CT) imaging in high-grade EC for LNM. Methodology Retrospective multicentre cohort study including patients (n=334) with preoperative high-grade EC and available CA125. Clinical data including imaging results, primary surgical treatment and final International Federation of Gynaecology and Obstetrics (FIGO) stage were recorded. CA125 was considered elevated at >35 IU/L. Result(s)*Patients with high-grade EC (n=334) and elevated CA125 more often presented with advanced FIGO stage (III-IV), 64.2% (95/148) versus 18.8% (35/186) in patients with normal CA125 (p<0.05). For patients with elevated CA125 who underwent surgical staging (n=192), the prevalence of LNM was 56.5% (39/69), compared to 14.6% (18/123) in patients with normal CA125 (p<0.05). For patients with preoperative CT imaging (n=148), LNM were suspected in 18.9% (28/148), but histologically confirmed in 27.7% (41/148) of the patients. Preoperative CA125 and CT findings for LNM in relation to risk of LNM are shown in table 1.
ER  -

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