Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
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BERNATSKY, Sasha (garant), Hector A Velasque GARCI, John J SPINELL, Patric GAFFNE, Karin E SMEDB, Rosalin RAMSEY-GOLDMA, Sophia S WAN, Hans-Olo ADAM, Demetriu ALBANE, Emanuel ANGELUCC, Stephen M ANSEL, Yan W ASMAN, Nikolau BECKE, Yoland BENAVENT, Sonja I BERND, Kimberly A BERTRAN, Brenda M BIRMAN, Heine BOEIN, Paol BOFFETT, Paige M BRACC, Pau BRENNA, Angela R BROOKS-WILSO, James R CERHA, Stephen J CHANOC, Jacquelin CLAVE, Luci COND, Karen H COTENBADE, David G CO, Wend COZE, Simo CROUC, Roo Anneclaire J DE, Sanjos Silvi DE, Loll Simonett DI, W Rya DIVE, Ahme DOGA, Lenka FORETOVÁ (203 Česká republika, domácí), Herv GHESQUIERE, Graham G GILE, Beng GLIMELIU, Thomas M HABERMAN, Corinn HAIOU, Patrici HARTG, Henri HJALGRI, Theodore R HOLFOR, Elizabeth A HOLL, Rebecca D JACKSO, Rudolp KAAK, Eleano KAN, Rachel S KELL, Robert J KLEI, Pete KRAF, Ann KRICKE, Qin LA, Lawrenc CHARLE, Mar LIEBO, Trac LIGHTFOO, Brian K LIN, Mar MAYNADI, Jame MCKA, Mad MELBY, Thierry J MOLIN, Alai MONNEREA, Lindsay M MORTO, Alexandr NIETER, Kari E NORT, Anne J NOVA, Kennet OFFI, Mark P PURDU, Marc RAI, Jacque RIB, Ev ROMA, Nathanie ROTHMA, Gille SALLE, Gianluc SEVER, Richard K SEVERSO, Christine F SKIBOL, Susan L SLAGE, Ale SMIT, Martyn T SMIT, Melissa C SOUTHE, Anthon STAINE, Lauren R TERA, Carrie A THOMPSO, Herv TILL, Lesley F TINKE, Ann TJONNELAN, Jenn TURNE, Claire M VAJDI, Roel C H VERMEULE, Josep VIJA, Paol VINEI, Jarm VIRTAM, Zhaomin WAN, Stephani WEINSTEI, Thomas E WITZI, Andre ZELENET, Ann ZELENIUCH-JACQUOTT, Yawe ZHAN, Tongzhan ZHEN, Mariagrazi ZUCC a Ann E CLARK
Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
BERNATSKY, Sasha, Hector A Velasque GARCI, John J SPINELL, Patric GAFFNE, Karin E SMEDB, Rosalin RAMSEY-GOLDMA, Sophia S WAN, Hans-Olo ADAM, Demetriu ALBANE, Emanuel ANGELUCC, Stephen M ANSEL, Yan W ASMAN, Nikolau BECKE, Yoland BENAVENT, Sonja I BERND, Kimberly A BERTRAN, Brenda M BIRMAN, Heine BOEIN, Paol BOFFETT, Paige M BRACC, Pau BRENNA, Angela R BROOKS-WILSO, James R CERHA, Stephen J CHANOC, Jacquelin CLAVE, Luci COND, Karen H COTENBADE, David G CO, Wend COZE, Simo CROUC, Roo Anneclaire J DE, Sanjos Silvi DE, Loll Simonett DI, W Rya DIVE, Ahme DOGA, Lenka FORETOVÁ, Herv GHESQUIERE, Graham G GILE, Beng GLIMELIU, Thomas M HABERMAN, Corinn HAIOU, Patrici HARTG, Henri HJALGRI, Theodore R HOLFOR, Elizabeth A HOLL, Rebecca D JACKSO, Rudolp KAAK, Eleano KAN, Rachel S KELL, Robert J KLEI, Pete KRAF, Ann KRICKE, Qin LA, Lawrenc CHARLE, Mar LIEBO, Trac LIGHTFOO, Brian K LIN, Mar MAYNADI, Jame MCKA, Mad MELBY, Thierry J MOLIN, Alai MONNEREA, Lindsay M MORTO, Alexandr NIETER, Kari E NORT, Anne J NOVA, Kennet OFFI, Mark P PURDU, Marc RAI, Jacque RIB, Ev ROMA, Nathanie ROTHMA, Gille SALLE, Gianluc SEVER, Richard K SEVERSO, Christine F SKIBOL, Susan L SLAGE, Ale SMIT, Martyn T SMIT, Melissa C SOUTHE, Anthon STAINE, Lauren R TERA, Carrie A THOMPSO, Herv TILL, Lesley F TINKE, Ann TJONNELAN, Jenn TURNE, Claire M VAJDI, Roel C H VERMEULE, Josep VIJA, Paol VINEI, Jarm VIRTAM, Zhaomin WAN, Stephani WEINSTEI, Thomas E WITZI, Andre ZELENET, Ann ZELENIUCH-JACQUOTT, Yawe ZHAN, Tongzhan ZHEN, Mariagrazi ZUCC a Ann E CLARK. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. LUPUS SCIENCE & MEDICINE. London: BMJ, 2017, roč. 4, č. 1, s. 1-6. ISSN 2053-8790. Dostupné z: https://dx.doi.org/10.1136/lupus-2016-000187.
@article{1854528, author = {Bernatsky, Sasha and Garci, Hector A Velasque and Spinell, John J and Gaffne, Patric and Smedb, Karin E and RamseyandGoldma, Rosalin and Wan, Sophia S and Adam, HansandOlo and Albane, Demetriu and Angelucc, Emanuel and Ansel, Stephen M and Asman, Yan W and Becke, Nikolau and Benavent, Yoland and Bernd, Sonja I and Bertran, Kimberly A and Birman, Brenda M and Boein, Heine and Boffett, Paol and Bracc, Paige M and Brenna, Pau and BrooksandWilso, Angela R and Cerha, James R and Chanoc, Stephen J and Clave, Jacquelin and Cond, Luci and Cotenbade, Karen H and Co, David G and Coze, Wend and Crouc, Simo and De, Roo Anneclaire J and de, Sanjos Silvi and Di, Loll Simonett and Dive, W Rya and Doga, Ahme and Foretová, Lenka and Ghesquiere, Herv and Gile, Graham G and Glimeliu, Beng and Haberman, Thomas M and Haiou, Corinn and Hartg, Patrici and Hjalgri, Henri and Holfor, Theodore R and Holl, Elizabeth A and Jackso, Rebecca D and Kaak, Rudolp and Kan, Eleano and Kell, Rachel S and Klei, Robert J and Kraf, Pete and Kricke, Ann and La, Qin and Charle, Lawrenc and Liebo, Mar and Lightfoo, Trac and Lin, Brian K and Maynadi, Mar and Mcka, Jame and Melby, Mad and Molin, Thierry J and Monnerea, Alai and Morto, Lindsay M and Nieter, Alexandr and Nort, Kari E and Nova, Anne J and Offi, Kennet and Purdu, Mark P and Rai, Marc and Rib, Jacque and Roma, Ev and Rothma, Nathanie and Salle, Gille and Sever, Gianluc and Severso, Richard K and Skibol, Christine F and Slage, Susan L and Smit, Ale and Smit, Martyn T and Southe, Melissa C and Staine, Anthon and Tera, Lauren R and Thompso, Carrie A and Till, Herv and Tinke, Lesley F and Tjonnelan, Ann and Turne, Jenn and Vajdi, Claire M and Vermeule, Roel C H and Vija, Josep and Vinei, Paol and Virtam, Jarm and Wan, Zhaomin and Weinstei, Stephani and Witzi, Thomas E and Zelenet, Andre and ZeleniuchandJacquott, Ann and Zhan, Yawe and Zhen, Tongzhan and Zucc, Mariagrazi and Clark, Ann E}, article_location = {London}, article_number = {1}, doi = {http://dx.doi.org/10.1136/lupus-2016-000187}, keywords = {B-cell lymphoma; Lupus-related single nucleotide polymorphisms}, language = {eng}, issn = {2053-8790}, journal = {LUPUS SCIENCE & MEDICINE}, title = {Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma}, url = {https://lupus.bmj.com/content/4/1/e000187}, volume = {4}, year = {2017} }
TY - JOUR ID - 1854528 AU - Bernatsky, Sasha - Garci, Hector A Velasque - Spinell, John J - Gaffne, Patric - Smedb, Karin E - Ramsey-Goldma, Rosalin - Wan, Sophia S - Adam, Hans-Olo - Albane, Demetriu - Angelucc, Emanuel - Ansel, Stephen M - Asman, Yan W - Becke, Nikolau - Benavent, Yoland - Bernd, Sonja I - Bertran, Kimberly A - Birman, Brenda M - Boein, Heine - Boffett, Paol - Bracc, Paige M - Brenna, Pau - Brooks-Wilso, Angela R - Cerha, James R - Chanoc, Stephen J - Clave, Jacquelin - Cond, Luci - Cotenbade, Karen H - Co, David G - Coze, Wend - Crouc, Simo - De, Roo Anneclaire J - de, Sanjos Silvi - Di, Loll Simonett - Dive, W Rya - Doga, Ahme - Foretová, Lenka - Ghesquiere, Herv - Gile, Graham G - Glimeliu, Beng - Haberman, Thomas M - Haiou, Corinn - Hartg, Patrici - Hjalgri, Henri - Holfor, Theodore R - Holl, Elizabeth A - Jackso, Rebecca D - Kaak, Rudolp - Kan, Eleano - Kell, Rachel S - Klei, Robert J - Kraf, Pete - Kricke, Ann - La, Qin - Charle, Lawrenc - Liebo, Mar - Lightfoo, Trac - Lin, Brian K - Maynadi, Mar - Mcka, Jame - Melby, Mad - Molin, Thierry J - Monnerea, Alai - Morto, Lindsay M - Nieter, Alexandr - Nort, Kari E - Nova, Anne J - Offi, Kennet - Purdu, Mark P - Rai, Marc - Rib, Jacque - Roma, Ev - Rothma, Nathanie - Salle, Gille - Sever, Gianluc - Severso, Richard K - Skibol, Christine F - Slage, Susan L - Smit, Ale - Smit, Martyn T - Southe, Melissa C - Staine, Anthon - Tera, Lauren R - Thompso, Carrie A - Till, Herv - Tinke, Lesley F - Tjonnelan, Ann - Turne, Jenn - Vajdi, Claire M - Vermeule, Roel C H - Vija, Josep - Vinei, Paol - Virtam, Jarm - Wan, Zhaomin - Weinstei, Stephani - Witzi, Thomas E - Zelenet, Andre - Zeleniuch-Jacquott, Ann - Zhan, Yawe - Zhen, Tongzhan - Zucc, Mariagrazi - Clark, Ann E PY - 2017 TI - Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma JF - LUPUS SCIENCE & MEDICINE VL - 4 IS - 1 SP - 1-6 EP - 1-6 PB - BMJ SN - 20538790 KW - B-cell lymphoma KW - Lupus-related single nucleotide polymorphisms UR - https://lupus.bmj.com/content/4/1/e000187 N2 - Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE. ER -
BERNATSKY, Sasha, Hector A Velasque GARCI, John J SPINELL, Patric GAFFNE, Karin E SMEDB, Rosalin RAMSEY-GOLDMA, Sophia S WAN, Hans-Olo ADAM, Demetriu ALBANE, Emanuel ANGELUCC, Stephen M ANSEL, Yan W ASMAN, Nikolau BECKE, Yoland BENAVENT, Sonja I BERND, Kimberly A BERTRAN, Brenda M BIRMAN, Heine BOEIN, Paol BOFFETT, Paige M BRACC, Pau BRENNA, Angela R BROOKS-WILSO, James R CERHA, Stephen J CHANOC, Jacquelin CLAVE, Luci COND, Karen H COTENBADE, David G CO, Wend COZE, Simo CROUC, Roo Anneclaire J DE, Sanjos Silvi DE, Loll Simonett DI, W Rya DIVE, Ahme DOGA, Lenka FORETOVÁ, Herv GHESQUIERE, Graham G GILE, Beng GLIMELIU, Thomas M HABERMAN, Corinn HAIOU, Patrici HARTG, Henri HJALGRI, Theodore R HOLFOR, Elizabeth A HOLL, Rebecca D JACKSO, Rudolp KAAK, Eleano KAN, Rachel S KELL, Robert J KLEI, Pete KRAF, Ann KRICKE, Qin LA, Lawrenc CHARLE, Mar LIEBO, Trac LIGHTFOO, Brian K LIN, Mar MAYNADI, Jame MCKA, Mad MELBY, Thierry J MOLIN, Alai MONNEREA, Lindsay M MORTO, Alexandr NIETER, Kari E NORT, Anne J NOVA, Kennet OFFI, Mark P PURDU, Marc RAI, Jacque RIB, Ev ROMA, Nathanie ROTHMA, Gille SALLE, Gianluc SEVER, Richard K SEVERSO, Christine F SKIBOL, Susan L SLAGE, Ale SMIT, Martyn T SMIT, Melissa C SOUTHE, Anthon STAINE, Lauren R TERA, Carrie A THOMPSO, Herv TILL, Lesley F TINKE, Ann TJONNELAN, Jenn TURNE, Claire M VAJDI, Roel C H VERMEULE, Josep VIJA, Paol VINEI, Jarm VIRTAM, Zhaomin WAN, Stephani WEINSTEI, Thomas E WITZI, Andre ZELENET, Ann ZELENIUCH-JACQUOTT, Yawe ZHAN, Tongzhan ZHEN, Mariagrazi ZUCC a Ann E CLARK. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. \textit{LUPUS SCIENCE \&{} MEDICINE}. London: BMJ, 2017, roč.~4, č.~1, s.~1-6. ISSN~2053-8790. Dostupné z: https://dx.doi.org/10.1136/lupus-2016-000187.