Association of serum N-epsilon-Carboxy methyl lysine with
severity of diabetic retinopathy

J 2016

Association of serum N-epsilon-Carboxy methyl lysine with severity of diabetic retinopathy

MISHR, Nibh; Sandee SAXEN; Rajendra K SHUKL; Vinit SING; Carsten H MEYE et al.

Základní údaje

Originální název

Association of serum N-epsilon-Carboxy methyl lysine with severity of diabetic retinopathy

Autoři

MISHR, Nibh; Sandee SAXEN; Rajendra K SHUKL; Vinit SING; Carsten H MEYE; Peter KRUŽLIAK a Vinay K KHANN

Vydání

Journal of Diabetes and its Complications, New York, Elsevier Science Inc. 2016, 1056-8727

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.734

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00124650

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Diabetic retinopathy; Diabetic macular edema; Advanced glycation end products; N-epsilon-carboxy methyl lysine; External limiting membrane; Photoreceptor ellipsoid zone

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 5. 2022 11:03, Mgr. Tereza Miškechová

Anotace

V originále

Purpose: To correlate serum levels of N-epsilon-carboxy methyl lysine (N-epsilon-CML) with severity of retinopathy, in vivo macular edema and disruption of external limiting membrane (ELM) and photoreceptor ellipsoid zone in type 2 diabetes mellitus (DM). Methods: Consecutive cases of type 2 DM [diabetes mellitus with no retinopathy (No DR) (n = 20); non proliferative diabetic retinopathy (NPDR) with diabetic macular edema (n = 20); proliferative diabetic retinopathy with diabetic macular edema (PDR) (n = 20)] and healthy controls (n = 20) between the ages of 40 and 65 years were included (power of study = 93.8%). In vivo histology of retinal layers was assessed using spectral domain optical coherence tomography. Every study subject underwent macular thickness analysis using the macular cube 512 x 128 feature. Disruption of ELM and photoreceptor ellipsoid zone was graded: grade 0, no disruption of ELM and ellipsoid zone; grade 1, ELM disrupted and ellipsoid zone intact; grade 2, both ELM and ellipsoid zone disrupted. Data were statistically analyzed. Results: The mean levels of N-epsilon-CML were 31.34 +/- 21.23 ng/ml, 73.88 +/- 35.01 ng/ml, 91.21 +/- 66.65 ng/ml, and 132.08 +/- 84.07 ng/ml in control, No DR, NPDR and PDR respectively. N-epsilon-CML level was significantly different between the study groups (control, No DR, NPDR and PDR) (p < 0.001). Mean logMAR visual acuity decreased with increased levels of N-epsilon-CML (p < 0.001). The association of (NCML)-C-epsilon with the grades of disruption was found to be statistically significant (F value = 18.48, p < 0.001). Univariate analysis was done with N-epsilon-CML as a dependent variable. The values of N-epsilon-CML were normalized (log(10)) and were subjected to univariate analysis with fasting blood glucose level, glycosylated hemoglobin, central subfield macular thickness and cube average thickness among the diseased groups (NPDR and PDR) that act as confounders. It was found that none of the variables had significant effect on N-epsilon-CML (fasting blood glucose p = 0.12, HBA1c p = 0.65, central subfield macular thickness p = 0.13, cube average thickness p = 0.19). N-epsilon-CML tends to be a significant and important predictor of grade of ELM and ellipsoid zone disruption in diabetic retinopathy. Conclusions: Increased N-epsilon-CML levels are associated with increased severity of diabetic retinopathy, macular edema and structural changes in macula that is ELM and ellipsoid zone disruption, which serves as a prognosticator of visual outcome. (C) 2016 Elsevier Inc. All rights reserved.

Citovat

MISHR, Nibh; Sandee SAXEN; Rajendra K SHUKL; Vinit SING; Carsten H MEYE; Peter KRUŽLIAK a Vinay K KHANN. Association of serum N-epsilon-Carboxy methyl lysine with severity of diabetic retinopathy. Journal of Diabetes and its Complications. New York: Elsevier Science Inc., 2016, roč. 30, č. 3, s. 511-517. ISSN 1056-8727. Dostupné z: https://doi.org/10.1016/j.jdiacomp.2015.12.009.

@article{1854531,
   author = {Mishr, Nibh and Saxen, Sandee and Shukl, Rajendra K and Sing, Vinit and Meye, Carsten H and Kružliak, Peter and Khann, Vinay K},
   article_location = {New York},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.jdiacomp.2015.12.009},
   keywords = {Diabetic retinopathy; Diabetic macular edema; Advanced glycation end products; N-epsilon-carboxy methyl lysine; External limiting membrane; Photoreceptor ellipsoid zone},
   language = {eng},
   issn = {1056-8727},
   journal = {Journal of Diabetes and its Complications},
   title = {Association of serum N-epsilon-Carboxy methyl lysine with severity of diabetic retinopathy},
   url = {https://www.sciencedirect.com/science/article/pii/S1056872715004912?via%3Dihub},
   volume = {30},
   year = {2016}
}

TY  - JOUR
ID  - 1854531
AU  - Mishr, Nibh - Saxen, Sandee - Shukl, Rajendra K - Sing, Vinit - Meye, Carsten H - Kružliak, Peter - Khann, Vinay K
PY  - 2016
TI  - Association of serum N-epsilon-Carboxy methyl lysine with severity of diabetic retinopathy
JF  - Journal of Diabetes and its Complications
VL  - 30
IS  - 3
SP  - 511-517
EP  - 511-517
PB  - Elsevier Science Inc.
SN  - 10568727
KW  - Diabetic retinopathy
KW  - Diabetic macular edema
KW  - Advanced glycation end products
KW  - N-epsilon-carboxy methyl lysine
KW  - External limiting membrane
KW  - Photoreceptor ellipsoid zone
UR  - https://www.sciencedirect.com/science/article/pii/S1056872715004912?via%3Dihub
N2  - Purpose: To correlate serum levels of N-epsilon-carboxy methyl lysine (N-epsilon-CML) with severity of retinopathy, in vivo macular edema and disruption of external limiting membrane (ELM) and photoreceptor ellipsoid zone in type 2 diabetes mellitus (DM). Methods: Consecutive cases of type 2 DM [diabetes mellitus with no retinopathy (No DR) (n = 20); non proliferative diabetic retinopathy (NPDR) with diabetic macular edema (n = 20); proliferative diabetic retinopathy with diabetic macular edema (PDR) (n = 20)] and healthy controls (n = 20) between the ages of 40 and 65 years were included (power of study = 93.8%). In vivo histology of retinal layers was assessed using spectral domain optical coherence tomography. Every study subject underwent macular thickness analysis using the macular cube 512 x 128 feature. Disruption of ELM and photoreceptor ellipsoid zone was graded: grade 0, no disruption of ELM and ellipsoid zone; grade 1, ELM disrupted and ellipsoid zone intact; grade 2, both ELM and ellipsoid zone disrupted. Data were statistically analyzed. Results: The mean levels of N-epsilon-CML were 31.34 +/- 21.23 ng/ml, 73.88 +/- 35.01 ng/ml, 91.21 +/- 66.65 ng/ml, and 132.08 +/- 84.07 ng/ml in control, No DR, NPDR and PDR respectively. N-epsilon-CML level was significantly different between the study groups (control, No DR, NPDR and PDR) (p < 0.001). Mean logMAR visual acuity decreased with increased levels of N-epsilon-CML (p < 0.001). The association of (NCML)-C-epsilon with the grades of disruption was found to be statistically significant (F value = 18.48, p < 0.001). Univariate analysis was done with N-epsilon-CML as a dependent variable. The values of N-epsilon-CML were normalized (log(10)) and were subjected to univariate analysis with fasting blood glucose level, glycosylated hemoglobin, central subfield macular thickness and cube average thickness among the diseased groups (NPDR and PDR) that act as confounders. It was found that none of the variables had significant effect on N-epsilon-CML (fasting blood glucose p = 0.12, HBA1c p = 0.65, central subfield macular thickness p = 0.13, cube average thickness p = 0.19). N-epsilon-CML tends to be a significant and important predictor of grade of ELM and ellipsoid zone disruption in diabetic retinopathy. Conclusions: Increased N-epsilon-CML levels are associated with increased severity of diabetic retinopathy, macular edema and structural changes in macula that is ELM and ellipsoid zone disruption, which serves as a prognosticator of visual outcome. (C) 2016 Elsevier Inc. All rights reserved.
ER  -

MISHR, Nibh; Sandee SAXEN; Rajendra K SHUKL; Vinit SING; Carsten H MEYE; Peter KRUŽLIAK a Vinay K KHANN. Association of serum N-epsilon-Carboxy methyl lysine with severity of diabetic retinopathy. \textit{Journal of Diabetes and its Complications}. New York: Elsevier Science Inc., 2016, roč.~30, č.~3, s.~511-517. ISSN~1056-8727. Dostupné z: https://doi.org/10.1016/j.jdiacomp.2015.12.009.

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