Q waves are the strongest electrocardiographic variable
associated with primary prophylactic implantable
cardioverter-defibrillator benefit: a prospective multicentre
study

J 2022

Q waves are the strongest electrocardiographic variable associated with primary prophylactic implantable cardioverter-defibrillator benefit: a prospective multicentre study

PELLI, Ari, Juhani M. JUNTTILA, Tuomas V. KENTTÄ, Simon SCHLÖGL, Markus ZABEL et. al.

Základní údaje

Originální název

Q waves are the strongest electrocardiographic variable associated with primary prophylactic implantable cardioverter-defibrillator benefit: a prospective multicentre study

Autoři

PELLI, Ari, Juhani M. JUNTTILA (garant), Tuomas V. KENTTÄ, Simon SCHLÖGL, Markus ZABEL, Marek MALÍK (203 Česká republika, domácí), Tobias REICHLIN, Rik WILLEMS, Marc A. VOS, Markus HARDEN, Tim FRIEDE, Christian STICHERLING a Heikki V HUIKURI

Vydání

EP Europace, Oxford, Oxford University Press, 2022, 1099-5129

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.100

Kód RIV

RIV/00216224:14110/22:00125980

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1093/europace/euab260

UT WoS

000790073500001

Klíčová slova anglicky

Implantable cardioverter-defibrillator; Primary prevention; Mortality; Appropriate shock; Benefit; Heart failure; Electrocardiogram; Q wave; QT interval

Štítky

14110211, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 6. 2022 14:31, Mgr. Tereza Miškechová

Anotace

V originále

Aim The association of standard 12-lead electrocardiogram (ECG) markers with benefits of the primary prophylactic implantable cardioverter-defibrillator (ICD) has not been determined in the contemporary era. We analysed traditional and novel ECG variables in a large prospective, controlled primary prophylactic ICD population to assess the predictive value of ECG in terms of ICD benefit. Methods and results Electrocardiograms from 1477 ICD patients and 700 control patients (EU-CERT-ICD; non-randomized, controlled, prospective multicentre study; ClinicalTrials.gov Identifier: NCT02064192), who met ICD implantation criteria but did not receive the device, were analysed. The primary outcome was all-cause mortality. In ICD patients, the co-primary outcome of first appropriate shock was used. Mean follow-up time was 2.4 +/- 1.1 years to death and 2.3 +/- 1.2 years to the first appropriate shock. Pathological Q waves were associated with decreased mortality in ICD patients [hazard ratio (HR) 0.54, 95% confidence interval (CI) 0.35-0.84; P < 0.01] and patients with pathological Q waves had significantly more benefit from ICD (HR 0.44, 95% CI 0.21-0.93; P = 0.03). QTc interval increase taken as a continuous variable was associated with both mortality and appropriate shock incidence, but commonly used cut-off values, were not statistically significantly associated with either of the outcomes. Conclusion Pathological Q waves were a strong ECG predictor of ICD benefit in primary prophylactic ICD patients. Excess mortality among Q wave patients seems to be due to arrhythmic death which can be prevented by ICD.

Citovat

PELLI, Ari, Juhani M. JUNTTILA, Tuomas V. KENTTÄ, Simon SCHLÖGL, Markus ZABEL, Marek MALÍK, Tobias REICHLIN, Rik WILLEMS, Marc A. VOS, Markus HARDEN, Tim FRIEDE, Christian STICHERLING a Heikki V HUIKURI. Q waves are the strongest electrocardiographic variable associated with primary prophylactic implantable cardioverter-defibrillator benefit: a prospective multicentre study. EP Europace. Oxford: Oxford University Press, 2022, roč. 24, č. 5, s. 774-783. ISSN 1099-5129. Dostupné z: https://dx.doi.org/10.1093/europace/euab260.

@article{1859440,
   author = {Pelli, Ari and Junttila, Juhani M. and Kenttä, Tuomas V. and Schlögl, Simon and Zabel, Markus and Malík, Marek and Reichlin, Tobias and Willems, Rik and Vos, Marc A. and Harden, Markus and Friede, Tim and Sticherling, Christian and Huikuri, Heikki V},
   article_location = {Oxford},
   article_number = {5},
   doi = {http://dx.doi.org/10.1093/europace/euab260},
   keywords = {Implantable cardioverter-defibrillator; Primary prevention; Mortality; Appropriate shock; Benefit; Heart failure; Electrocardiogram; Q wave; QT interval},
   language = {eng},
   issn = {1099-5129},
   journal = {EP Europace},
   title = {Q waves are the strongest electrocardiographic variable associated with primary prophylactic implantable cardioverter-defibrillator benefit: a prospective multicentre study},
   url = {https://academic.oup.com/europace/article/24/5/774/6446242?login=true},
   volume = {24},
   year = {2022}
}

TY  - JOUR
ID  - 1859440
AU  - Pelli, Ari - Junttila, Juhani M. - Kenttä, Tuomas V. - Schlögl, Simon - Zabel, Markus - Malík, Marek - Reichlin, Tobias - Willems, Rik - Vos, Marc A. - Harden, Markus - Friede, Tim - Sticherling, Christian - Huikuri, Heikki V
PY  - 2022
TI  - Q waves are the strongest electrocardiographic variable associated with primary prophylactic implantable cardioverter-defibrillator benefit: a prospective multicentre study
JF  - EP Europace
VL  - 24
IS  - 5
SP  - 774-783
EP  - 774-783
PB  - Oxford University Press
SN  - 10995129
KW  - Implantable cardioverter-defibrillator
KW  - Primary prevention
KW  - Mortality
KW  - Appropriate shock
KW  - Benefit
KW  - Heart failure
KW  - Electrocardiogram
KW  - Q wave
KW  - QT interval
UR  - https://academic.oup.com/europace/article/24/5/774/6446242?login=true
N2  - Aim The association of standard 12-lead electrocardiogram (ECG) markers with benefits of the primary prophylactic implantable cardioverter-defibrillator (ICD) has not been determined in the contemporary era. We analysed traditional and novel ECG variables in a large prospective, controlled primary prophylactic ICD population to assess the predictive value of ECG in terms of ICD benefit. Methods and results Electrocardiograms from 1477 ICD patients and 700 control patients (EU-CERT-ICD; non-randomized, controlled, prospective multicentre study; ClinicalTrials.gov Identifier: NCT02064192), who met ICD implantation criteria but did not receive the device, were analysed. The primary outcome was all-cause mortality. In ICD patients, the co-primary outcome of first appropriate shock was used. Mean follow-up time was 2.4 +/- 1.1 years to death and 2.3 +/- 1.2 years to the first appropriate shock. Pathological Q waves were associated with decreased mortality in ICD patients [hazard ratio (HR) 0.54, 95% confidence interval (CI) 0.35-0.84; P < 0.01] and patients with pathological Q waves had significantly more benefit from ICD (HR 0.44, 95% CI 0.21-0.93; P = 0.03). QTc interval increase taken as a continuous variable was associated with both mortality and appropriate shock incidence, but commonly used cut-off values, were not statistically significantly associated with either of the outcomes. Conclusion Pathological Q waves were a strong ECG predictor of ICD benefit in primary prophylactic ICD patients. Excess mortality among Q wave patients seems to be due to arrhythmic death which can be prevented by ICD.
ER  -

PELLI, Ari, Juhani M. JUNTTILA, Tuomas V. KENTTÄ, Simon SCHLÖGL, Markus ZABEL, Marek MALÍK, Tobias REICHLIN, Rik WILLEMS, Marc A. VOS, Markus HARDEN, Tim FRIEDE, Christian STICHERLING a Heikki V HUIKURI. Q waves are the strongest electrocardiographic variable associated with primary prophylactic implantable cardioverter-defibrillator benefit: a prospective multicentre study. \textit{EP Europace}. Oxford: Oxford University Press, 2022, roč.~24, č.~5, s.~774-783. ISSN~1099-5129. Dostupné z: https://dx.doi.org/10.1093/europace/euab260.

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