LENÁRT, Sára, Peter LENÁRT, Lucia KNOPFOVÁ, Hana KOTASOVÁ, Vendula PELKOVÁ, Veronika SEDLÁKOVÁ, Ondřej VACEK, Jana POKLUDOVÁ, Vladimír ČAN, Jan ŠMARDA, Karel SOUČEK, Aleš HAMPL a Petr BENEŠ. TACSTD2 upregulation is an early reaction to lung infection. Nature Scientific Reports. London: NATURE RESEARCH, 2022, roč. 12, č. 1, s. 9583-9597. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-13637-9. |
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@article{1860591, author = {Lenárt, Sára and Lenárt, Peter and Knopfová, Lucia and Kotasová, Hana and Pelková, Vendula and Sedláková, Veronika and Vacek, Ondřej and Pokludová, Jana and Čan, Vladimír and Šmarda, Jan and Souček, Karel and Hampl, Aleš and Beneš, Petr}, article_location = {London}, article_number = {1}, doi = {http://dx.doi.org/10.1038/s41598-022-13637-9}, keywords = {INNATE IMMUNE-RESPONSE; NF-KAPPA-B; EXPRESSION ATLAS; VIRAL-INFECTION; BARRIER; CELLS; GENE; IDENTIFICATION; CANCER; MURINE}, language = {eng}, issn = {2045-2322}, journal = {Nature Scientific Reports}, title = {TACSTD2 upregulation is an early reaction to lung infection}, url = {https://www.nature.com/articles/s41598-022-13637-9}, volume = {12}, year = {2022} }
TY - JOUR ID - 1860591 AU - Lenárt, Sára - Lenárt, Peter - Knopfová, Lucia - Kotasová, Hana - Pelková, Vendula - Sedláková, Veronika - Vacek, Ondřej - Pokludová, Jana - Čan, Vladimír - Šmarda, Jan - Souček, Karel - Hampl, Aleš - Beneš, Petr PY - 2022 TI - TACSTD2 upregulation is an early reaction to lung infection JF - Nature Scientific Reports VL - 12 IS - 1 SP - 9583 EP - 9583 PB - NATURE RESEARCH SN - 20452322 KW - INNATE IMMUNE-RESPONSE KW - NF-KAPPA-B KW - EXPRESSION ATLAS KW - VIRAL-INFECTION KW - BARRIER KW - CELLS KW - GENE KW - IDENTIFICATION KW - CANCER KW - MURINE UR - https://www.nature.com/articles/s41598-022-13637-9 N2 - TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved for cancer therapy, the physiological role of Trop2 is still not fully understood. In this article, we show that TACSTD2/Trop2 expression is evolutionarily conserved in lungs of various vertebrates. By analysis of publicly available transcriptomic data we demonstrate that TACSTD2 level consistently increases in lungs infected with miscellaneous, but mainly viral pathogens. Single cell and subpopulation based transcriptomic data revealed that the major source of TACSTD2 transcript are lung epithelial cells and their progenitors and that TACSTD2 is induced directly in lung epithelial cells following infection. Increase in TACSTD2 expression may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs. ER -
LENÁRT, Sára, Peter LENÁRT, Lucia KNOPFOVÁ, Hana KOTASOVÁ, Vendula PELKOVÁ, Veronika SEDLÁKOVÁ, Ondřej VACEK, Jana POKLUDOVÁ, Vladimír ČAN, Jan ŠMARDA, Karel SOUČEK, Aleš HAMPL a Petr BENEŠ. TACSTD2 upregulation is an early reaction to lung infection. \textit{Nature Scientific Reports}. London: NATURE RESEARCH, 2022, roč.~12, č.~1, s.~9583-9597. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-13637-9.
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