Somatic Mutations in Exon 7 of the TP53 Gene in Index
Colorectal Lesions Are Associated with the Early Occurrence of
Metachronous Adenoma

J 2022

Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma

HÁLKOVÁ, Tereza; Renata PTÁČKOVÁ; Anastasiya SEMYAKINA; Štěpán SUCHÁNEK; Eva TRABOULSI et al.

Základní údaje

Originální název

Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma

Autoři

Vydání

Cancers, Basel, MDPI, 2022, 2072-6694

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.200

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/22:00129671

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

colorectal cancer; colorectal adenomas; colonoscopy; index lesion; synchronous lesion; metachronous lesion; tumor heterogeneity; TP53

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 7. 2022 13:04, Mgr. Tereza Miškechová

Anotace

V originále

(1) Background: this prospective study was focused on detailed analysis of the mutation heterogeneity in colorectal lesions removed during baseline (index) colonoscopy to identify patients at high risk of early occurrence of metachronous adenomas. (2) Methods: a total of 120 patients after endoscopic therapy of advanced colorectal neoplasia size ≥10 mm (index lesion) with subsequent surveillance colonoscopy after 10–18 months were included. In total, 143 index lesions and 84 synchronous lesions in paraffin blocks were divided into up to 30 samples. In each of them, the detection of somatic mutations in 11 hot spot gene loci was performed. Statistical analysis to correlate the mutation profiles and the degree of heterogeneity of the lesions with the risk of metachronous adenoma occurrence was undertaken. (3) Results: mutation in exon 7 of the TP53 gene found in the index lesion significantly correlated with the early occurrence of metachronous adenoma (log-rank test p = 0.003, hazard ratio 2.73, 95% confidence interval 1.14–6.56). We did not find an association between the risk of metachronous adenomas and other markers monitored. (4) Conclusions: the findings of this study could lead to an adjustment of existing recommendations for surveillance colonoscopies in a specific group of patients with mutations in exon 7 of the TP53 gene in an index lesion, where a shortening of surveillance interval may be warranted.

Návaznosti

NV17-31909A, projekt VaV

Název: Vývoj multiparametrického testu nové generace pro predikci rizika rekurence kolorektální neoplázie

Citovat

HÁLKOVÁ, Tereza; Renata PTÁČKOVÁ; Anastasiya SEMYAKINA; Štěpán SUCHÁNEK; Eva TRABOULSI; Ondřej NGO; Kateřina HEJCMANOVÁ; Ondřej MÁJEK; Jan BUREŠ; Miroslav ZAVORAL; Marek MINÁRIK a Lucie BENEŠOVÁ. Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma. Cancers. Basel: MDPI, 2022, roč. 14, č. 12, s. 1-12. ISSN 2072-6694. Dostupné z: https://doi.org/10.3390/cancers14122823.

@article{1863061,
   author = {Hálková, Tereza and Ptáčková, Renata and Semyakina, Anastasiya and Suchánek, Štěpán and Traboulsi, Eva and Ngo, Ondřej and Hejcmanová, Kateřina and Májek, Ondřej and Bureš, Jan and Zavoral, Miroslav and Minárik, Marek and Benešová, Lucie},
   article_location = {Basel},
   article_number = {12},
   doi = {https://doi.org/10.3390/cancers14122823},
   keywords = {colorectal cancer; colorectal adenomas; colonoscopy; index lesion; synchronous lesion; metachronous lesion; tumor heterogeneity; TP53},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma},
   url = {https://www.mdpi.com/2072-6694/14/12/2823},
   volume = {14},
   year = {2022}
}

TY  - JOUR
ID  - 1863061
AU  - Hálková, Tereza - Ptáčková, Renata - Semyakina, Anastasiya - Suchánek, Štěpán - Traboulsi, Eva - Ngo, Ondřej - Hejcmanová, Kateřina - Májek, Ondřej - Bureš, Jan - Zavoral, Miroslav - Minárik, Marek - Benešová, Lucie
PY  - 2022
TI  - Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma
JF  - Cancers
VL  - 14
IS  - 12
SP  - 1-12
EP  - 1-12
PB  - MDPI
SN  - 20726694
KW  - colorectal cancer
KW  - colorectal adenomas
KW  - colonoscopy
KW  - index lesion
KW  - synchronous lesion
KW  - metachronous lesion
KW  - tumor heterogeneity
KW  - TP53
UR  - https://www.mdpi.com/2072-6694/14/12/2823
N2  - (1) Background: this prospective study was focused on detailed analysis of the mutation heterogeneity in colorectal lesions removed during baseline (index) colonoscopy to identify patients at high risk of early occurrence of metachronous adenomas. (2) Methods: a total of 120 patients after endoscopic therapy of advanced colorectal neoplasia size ≥10 mm (index lesion) with subsequent surveillance colonoscopy after 10–18 months were included. In total, 143 index lesions and 84 synchronous lesions in paraffin blocks were divided into up to 30 samples. In each of them, the detection of somatic mutations in 11 hot spot gene loci was performed. Statistical analysis to correlate the mutation profiles and the degree of heterogeneity of the lesions with the risk of metachronous adenoma occurrence was undertaken. (3) Results: mutation in exon 7 of the TP53 gene found in the index lesion significantly correlated with the early occurrence of metachronous adenoma (log-rank test p = 0.003, hazard ratio 2.73, 95% confidence interval 1.14–6.56). We did not find an association between the risk of metachronous adenomas and other markers monitored. (4) Conclusions: the findings of this study could lead to an adjustment of existing recommendations for surveillance colonoscopies in a specific group of patients with mutations in exon 7 of the TP53 gene in an index lesion, where a shortening of surveillance interval may be warranted.
ER  -

HÁLKOVÁ, Tereza; Renata PTÁČKOVÁ; Anastasiya SEMYAKINA; Štěpán SUCHÁNEK; Eva TRABOULSI; Ondřej NGO; Kateřina HEJCMANOVÁ; Ondřej MÁJEK; Jan BUREŠ; Miroslav ZAVORAL; Marek MINÁRIK a Lucie BENEŠOVÁ. Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma. \textit{Cancers}. Basel: MDPI, 2022, roč.~14, č.~12, s.~1-12. ISSN~2072-6694. Dostupné z: https://doi.org/10.3390/cancers14122823.

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