Colloidal lithography as a novel approach for the development
of Ni-nanocavity insulin sensor

J 2022

Colloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor

ŠIŠOLÁKOVÁ, Ivana, Ondrej PETRUŠ, Jana SHEPA, Zdeněk FARKA, Andrej ORIŇÁK et. al.

Základní údaje

Originální název

Colloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor

Autoři

ŠIŠOLÁKOVÁ, Ivana (703 Slovensko), Ondrej PETRUŠ (703 Slovensko), Jana SHEPA (703 Slovensko), Zdeněk FARKA (203 Česká republika, garant, domácí), Andrej ORIŇÁK (703 Slovensko) a Renáta ORIŇAKOVÁ

Vydání

Scientific Reports, Springer Nature, 2022, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

21001 Nano-materials

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.600

Kód RIV

RIV/00216224:14310/22:00129981

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1038/s41598-022-15283-7

UT WoS

001014944000030

Klíčová slova anglicky

electrochemical sensor; insulin; colloidal lithography; nanostructures

Štítky

CF NANO, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 10. 2024 10:29, Ing. Monika Szurmanová, Ph.D.

Anotace

V originále

In this study, a highly sensitive, fast, and selective enzyme-free electrochemical sensor based on the deposition of Ni cavities on conductive glass was proposed for insulin detection. Considering the growing prevalence of diabetes mellitus, an electrochemical sensor for the determination of insulin was proposed for the effective diagnosis of the disease. Colloidal lithography enabled deposition of nanostructured layer (substrate) with homogeneous distribution of Ni cavities on the electrode surface with a large active surface area. The morphology and structure of conductive indium tin oxide glass modified with Ni cavities (Ni-c-ITO) were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The diameter of the resulting cavities was approximately 500 nm, while their depth was calculated at 190 ± 4 nm and 188 ± 18 nm using AFM and SEM, respectively. The insulin assay performance was evaluated by cyclic voltammetry. Ni-c-ITO exhibited excellent analytical characteristics, including high sensitivity (1.032 µA µmol−1 dm3), a low detection limit (156 µmol dm−3), and a wide dynamic range (500 nmol dm−3 to 10 µmol dm−3). Finally, the determination of insulin in buffer with interferents and in real blood serum samples revealed high specificity and demonstrated the practical potential of the method.

Návaznosti

22020140, interní kód MU

Název: Věda v zemích V4 - výzkum nových senzorů pro diagnostiku diabetu (Akronym: Věda v zemích V4 - výzkum nových senzorů)

Investor: Mezinárodní visegrádský fond (IVF), Věda v zemích V4 - výzkum nových senzorů pro diagnostiku diabetu

90127, velká výzkumná infrastruktura

Název: CIISB II

Citovat

ŠIŠOLÁKOVÁ, Ivana, Ondrej PETRUŠ, Jana SHEPA, Zdeněk FARKA, Andrej ORIŇÁK a Renáta ORIŇAKOVÁ. Colloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor. Scientific Reports. Springer Nature, 2022, roč. 12, č. 1, s. 1-12. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-15283-7.

@article{1863572,
   author = {Šišoláková, Ivana and Petruš, Ondrej and Shepa, Jana and Farka, Zdeněk and Oriňák, Andrej and Oriňaková, Renáta},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-15283-7},
   keywords = {electrochemical sensor; insulin; colloidal lithography; nanostructures},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Colloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor},
   url = {https://www.nature.com/articles/s41598-022-15283-7},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 1863572
AU  - Šišoláková, Ivana - Petruš, Ondrej - Shepa, Jana - Farka, Zdeněk - Oriňák, Andrej - Oriňaková, Renáta
PY  - 2022
TI  - Colloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor
JF  - Scientific Reports
VL  - 12
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - Springer Nature
SN  - 20452322
KW  - electrochemical sensor
KW  - insulin
KW  - colloidal lithography
KW  - nanostructures
UR  - https://www.nature.com/articles/s41598-022-15283-7
N2  - In this study, a highly sensitive, fast, and selective enzyme-free electrochemical sensor based on the deposition of Ni cavities on conductive glass was proposed for insulin detection. Considering the growing prevalence of diabetes mellitus, an electrochemical sensor for the determination of insulin was proposed for the effective diagnosis of the disease. Colloidal lithography enabled deposition of nanostructured layer (substrate) with homogeneous distribution of Ni cavities on the electrode surface with a large active surface area. The morphology and structure of conductive indium tin oxide glass modified with Ni cavities (Ni-c-ITO) were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The diameter of the resulting cavities was approximately 500 nm, while their depth was calculated at 190 ± 4 nm and 188 ± 18 nm using AFM and SEM, respectively. The insulin assay performance was evaluated by cyclic voltammetry. Ni-c-ITO exhibited excellent analytical characteristics, including high sensitivity (1.032 µA µmol−1 dm3), a low detection limit (156 µmol dm−3), and a wide dynamic range (500 nmol dm−3 to 10 µmol dm−3). Finally, the determination of insulin in buffer with interferents and in real blood serum samples revealed high specificity and demonstrated the practical potential of the method.
ER  -

ŠIŠOLÁKOVÁ, Ivana, Ondrej PETRUŠ, Jana SHEPA, Zdeněk FARKA, Andrej ORIŇÁK a Renáta ORIŇAKOVÁ. Colloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor. \textit{Scientific Reports}. Springer Nature, 2022, roč.~12, č.~1, s.~1-12. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-022-15283-7.

Podrobný výpis o publikaci