Protection provided by vaccination, booster doses and previous
infection against covid-19 infection, hospitalisation or death
over time in Czechia

J 2022

Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia

BEREC, Luděk; Martin ŠMÍD; Lenka PŘIBYLOVÁ; Ondřej MÁJEK; Tomáš PAVLÍK et. al.

Základní údaje

Originální název

Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia

Autoři

BEREC, Luděk (garant); Martin ŠMÍD; Lenka PŘIBYLOVÁ (203 Česká republika, domácí); Ondřej MÁJEK (203 Česká republika, domácí); Tomáš PAVLÍK (203 Česká republika, domácí); Jiří JARKOVSKÝ (203 Česká republika, domácí); Milan ZAJÍČEK; Jakub WEINER; Tamara BARUSOVÁ a Jan TRNKA

Vydání

PLoS ONE, Public Library of Science, 2022, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.700

Kód RIV

RIV/00216224:14110/22:00126311

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1371/journal.pone.0270801

UT WoS

000844536800079

EID Scopus

2-s2.0-85133679431

Klíčová slova anglicky

COVID 19; SARS CoV 2; Viral vaccines; Vaccines; Czech Republic; Immunity; Vaccination and immunization; Booster doses

Štítky

14119612, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 1. 2023 11:16, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Studies demonstrating the waning of post-vaccination and post-infection immunity against covid-19 generally analyzed a limited range of vaccines or subsets of populations. Using Czech national health data from the beginning of the covid-19 pandemic till November 20, 2021 we estimated the risks of reinfection, breakthrough infection, hospitalization and death by a Cox regression adjusted for sex, age, vaccine type and vaccination status. Vaccine effectiveness against infection declined from 87% at 0-2 months after the second dose to 53% at 7-8 months for BNT162b2 vaccine, from 90% at 0-2 months to 65% at 7-8 months for mRNA-1273, and from 83% at 0-2 months to 55% at 5-6 months for the ChAdOx1-S. Effectiveness against hospitalization and deaths declined by about 15% and 10%, respectively, during the first 6-8 months. Boosters (third dose) returned the protection to the levels observed shortly after dose 2. In unvaccinated, previously infected individuals the protection against infection declined from 97% after 2 months to 72% at 18 months. Our results confirm the waning of vaccination-induced immunity against infection and a smaller decline in the protection against hospitalization and death. Boosting restores the original vaccine effectiveness. Post-infection immunity also decreases over time.

Citovat

BEREC, Luděk; Martin ŠMÍD; Lenka PŘIBYLOVÁ; Ondřej MÁJEK; Tomáš PAVLÍK; Jiří JARKOVSKÝ; Milan ZAJÍČEK; Jakub WEINER; Tamara BARUSOVÁ a Jan TRNKA. Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia. PLoS ONE. Public Library of Science, 2022, roč. 17, č. 7, s. 1-13. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0270801.

@article{1876015,
   author = {Berec, Luděk and Šmíd, Martin and Přibylová, Lenka and Májek, Ondřej and Pavlík, Tomáš and Jarkovský, Jiří and Zajíček, Milan and Weiner, Jakub and Barusová, Tamara and Trnka, Jan},
   article_number = {7},
   doi = {http://dx.doi.org/10.1371/journal.pone.0270801},
   keywords = {COVID 19; SARS CoV 2; Viral vaccines; Vaccines; Czech Republic; Immunity; Vaccination and immunization; Booster doses},
   language = {eng},
   issn = {1932-6203},
   journal = {PLoS ONE},
   title = {Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia},
   url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270801},
   volume = {17},
   year = {2022}
}

TY  - JOUR
ID  - 1876015
AU  - Berec, Luděk - Šmíd, Martin - Přibylová, Lenka - Májek, Ondřej - Pavlík, Tomáš - Jarkovský, Jiří - Zajíček, Milan - Weiner, Jakub - Barusová, Tamara - Trnka, Jan
PY  - 2022
TI  - Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia
JF  - PLoS ONE
VL  - 17
IS  - 7
SP  - 1-13
EP  - 1-13
PB  - Public Library of Science
SN  - 19326203
KW  - COVID 19
KW  - SARS CoV 2
KW  - Viral vaccines
KW  - Vaccines
KW  - Czech Republic
KW  - Immunity
KW  - Vaccination and immunization
KW  - Booster doses
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270801
N2  - Studies demonstrating the waning of post-vaccination and post-infection immunity against covid-19 generally analyzed a limited range of vaccines or subsets of populations. Using Czech national health data from the beginning of the covid-19 pandemic till November 20, 2021 we estimated the risks of reinfection, breakthrough infection, hospitalization and death by a Cox regression adjusted for sex, age, vaccine type and vaccination status. Vaccine effectiveness against infection declined from 87% at 0-2 months after the second dose to 53% at 7-8 months for BNT162b2 vaccine, from 90% at 0-2 months to 65% at 7-8 months for mRNA-1273, and from 83% at 0-2 months to 55% at 5-6 months for the ChAdOx1-S. Effectiveness against hospitalization and deaths declined by about 15% and 10%, respectively, during the first 6-8 months. Boosters (third dose) returned the protection to the levels observed shortly after dose 2. In unvaccinated, previously infected individuals the protection against infection declined from 97% after 2 months to 72% at 18 months. Our results confirm the waning of vaccination-induced immunity against infection and a smaller decline in the protection against hospitalization and death. Boosting restores the original vaccine effectiveness. Post-infection immunity also decreases over time.
ER  -

BEREC, Luděk; Martin ŠMÍD; Lenka PŘIBYLOVÁ; Ondřej MÁJEK; Tomáš PAVLÍK; Jiří JARKOVSKÝ; Milan ZAJÍČEK; Jakub WEINER; Tamara BARUSOVÁ a Jan TRNKA. Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death over time in Czechia. \textit{PLoS ONE}. Public Library of Science, 2022, roč.~17, č.~7, s.~1-13. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0270801.

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