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@article{1876276,
author = {Salát, Jiří and Straková, Petra and Růžek, Daniel},
article_number = {7},
doi = {http://dx.doi.org/10.3390/vaccines10071001},
keywords = {tick-borne encephalitis virus; vaccine; non-structural protein 1},
language = {eng},
issn = {2076-393X},
journal = {Vaccines},
title = {Dynamics of Whole Virus and Non-Structural Protein 1 (NS1) IgG Response in Mice Immunized with Two Commercial Tick-Borne Encephalitis Vaccines.},
url = {https://www.mdpi.com/2076-393X/10/7/1001},
volume = {10},
year = {2022}
}
TY - JOUR
ID - 1876276
AU - Salát, Jiří - Straková, Petra - Růžek, Daniel
PY - 2022
TI - Dynamics of Whole Virus and Non-Structural Protein 1 (NS1) IgG Response in Mice Immunized with Two Commercial Tick-Borne Encephalitis Vaccines.
JF - Vaccines
VL - 10
IS - 7
SP - 1-6
EP - 1-6
PB - MDPI
SN - 2076393X
KW - tick-borne encephalitis virus
KW - vaccine
KW - non-structural protein 1
UR - https://www.mdpi.com/2076-393X/10/7/1001
N2 - The presence of a non-structural protein 1 (NS1) in tick-borne encephalitis (TBE) vaccines and the possible induction of an NS1-specific immune response in vaccinated individuals remains a somewhat controversial topic. Previously, we detected the presence of NS1 in the Encepur TBE vaccine by mass spectrometry and found the induction of NS1-specific IgG antibodies in mice vaccinated with the FSME-Immun TBE vaccine. Here, in this follow-up study, we examined the dynamics and extent of the NS1-specific IgG response in mice vaccinated with these two vaccines in more detail and compared it with the IgG response to the whole virus (WV). Mice were vaccinated at two-week intervals with a total of six doses of each vaccine, and levels of IgG antibodies to TBE virus WV and NS1 were measured by ELISA after each dose. Both vaccines elicited a robust anti-WV IgG response after two doses. The Encepur vaccine did not elicit NS1-specific IgG even after all six doses. In contrast, the FSME-Immun vaccine triggered the production of NS1-specific IgG after four doses. The results indicate that FSME-Immun is the only vaccine that elicits an NS1-specific antibody response in mice. However, compared to WV-specific IgG, the NS1-specific response is weaker, and a higher number of doses is required to induce detectable levels of NS1-specific IgG antibodies.
ER -
SALÁT, Jiří, Petra STRAKOVÁ a Daniel RŮŽEK. Dynamics of Whole Virus and Non-Structural Protein 1 (NS1) IgG Response in Mice Immunized with Two Commercial Tick-Borne Encephalitis Vaccines. \textit{Vaccines}. MDPI, 2022, roč.~10, č.~7, s.~1-6. ISSN~2076-393X. Dostupné z: https://dx.doi.org/10.3390/vaccines10071001.
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