Impaired lung function and mortality in Eastern Europe: results
from multi-centre cohort study

J 2022

Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study

SARYCHEVA, Tatyana Vladimirovna; Nadezda CAPKOVA; Andrzej PAJAK; Sofia MALYUTINA; Galina SIMONOVA et al.

Základní údaje

Originální název

Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study

Autoři

SARYCHEVA, Tatyana Vladimirovna; Nadezda CAPKOVA; Andrzej PAJAK; Sofia MALYUTINA; Galina SIMONOVA; Abdonas TAMOSIUNAS; Martin BOBÁK a Hynek PIKHART

Vydání

Respiratory Research, ENGLAND, BMC, 2022, 1465-993X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/22:00126377

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Forced expiratory volume in one second; Pulmonary function test; Cohort study; Mortality

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 6. 2025 07:01, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Background The association between impaired lung function and mortality has been well documented in the general population of Western European countries. We assessed the risk of death associated with reduced spirometry indices among people from four Central and Eastern European countries. Methods This prospective population-based cohort includes men and women aged 45-69 years, residents in urban settlements in Czech Republic, Poland, Russia and Lithuania, randomly selected from population registers. The baseline survey in 2002-2005 included 36,106 persons of whom 24,993 met the inclusion criteria. Cox proportional hazards models were used to estimate the hazard ratios of mortality over 11-16 years of follow-up for mild, moderate, moderate-severe and very severe lung function impairment categories. Results After adjusting for covariates, mild (hazard ratio (HR): 1.25; 95% CI 1.15-1.37) to severe (HR: 3.35; 95% CI 2.62-4.27) reduction in FEV1 was associated with an increased risk of death according to degree of lung impairment, compared to people with normal lung function. The association was only slightly attenuated but remained significant after exclusion of smokers and participants with previous history of respiratory diseases. The HRs varied between countries but not statistically significant; the highest excess risk among persons with more severe impairment was seen in Poland (HR: 4.28, 95% CI 2.14-8.56) and Lithuania (HR: 4.07, 95% CI 2.21-7.50). Conclusions Reduced FEV1 is an independent predictor of all-cause mortality, with risk increasing with the degree of lung function impairment and some country-specific variation between the cohorts.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

857487, interní kód MU

Název: R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research (Akronym: R-Exposome Chair)

Investor: Evropská unie, R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research, Spreading excellence and widening participation

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90121, velká výzkumná infrastruktura

Název: RECETOX RI

Přiložené soubory

1883611.pdf

Citovat

SARYCHEVA, Tatyana Vladimirovna; Nadezda CAPKOVA; Andrzej PAJAK; Sofia MALYUTINA; Galina SIMONOVA; Abdonas TAMOSIUNAS; Martin BOBÁK a Hynek PIKHART. Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study. Respiratory Research. ENGLAND: BMC, 2022, roč. 23, č. 1, s. 1-10. ISSN 1465-993X. Dostupné z: https://doi.org/10.1186/s12931-022-02057-y.

@article{1883611,
   author = {Sarycheva, Tatyana Vladimirovna and Capkova, Nadezda and Pajak, Andrzej and Malyutina, Sofia and Simonova, Galina and Tamosiunas, Abdonas and Bobák, Martin and Pikhart, Hynek},
   article_location = {ENGLAND},
   article_number = {1},
   doi = {https://doi.org/10.1186/s12931-022-02057-y},
   keywords = {Forced expiratory volume in one second; Pulmonary function test; Cohort study; Mortality},
   language = {eng},
   issn = {1465-993X},
   journal = {Respiratory Research},
   title = {Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study},
   url = {https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-02057-y},
   volume = {23},
   year = {2022}
}

TY  - JOUR
ID  - 1883611
AU  - Sarycheva, Tatyana Vladimirovna - Capkova, Nadezda - Pajak, Andrzej - Malyutina, Sofia - Simonova, Galina - Tamosiunas, Abdonas - Bobák, Martin - Pikhart, Hynek
PY  - 2022
TI  - Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study
JF  - Respiratory Research
VL  - 23
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - BMC
SN  - 1465993X
KW  - Forced expiratory volume in one second
KW  - Pulmonary function test
KW  - Cohort study
KW  - Mortality
UR  - https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-02057-y
N2  - Background The association between impaired lung function and mortality has been well documented in the general population of Western European countries. We assessed the risk of death associated with reduced spirometry indices among people from four Central and Eastern European countries. Methods This prospective population-based cohort includes men and women aged 45-69 years, residents in urban settlements in Czech Republic, Poland, Russia and Lithuania, randomly selected from population registers. The baseline survey in 2002-2005 included 36,106 persons of whom 24,993 met the inclusion criteria. Cox proportional hazards models were used to estimate the hazard ratios of mortality over 11-16 years of follow-up for mild, moderate, moderate-severe and very severe lung function impairment categories. Results After adjusting for covariates, mild (hazard ratio (HR): 1.25; 95% CI 1.15-1.37) to severe (HR: 3.35; 95% CI 2.62-4.27) reduction in FEV1 was associated with an increased risk of death according to degree of lung impairment, compared to people with normal lung function. The association was only slightly attenuated but remained significant after exclusion of smokers and participants with previous history of respiratory diseases. The HRs varied between countries but not statistically significant; the highest excess risk among persons with more severe impairment was seen in Poland (HR: 4.28, 95% CI 2.14-8.56) and Lithuania (HR: 4.07, 95% CI 2.21-7.50). Conclusions Reduced FEV1 is an independent predictor of all-cause mortality, with risk increasing with the degree of lung function impairment and some country-specific variation between the cohorts.
ER  -

SARYCHEVA, Tatyana Vladimirovna; Nadezda CAPKOVA; Andrzej PAJAK; Sofia MALYUTINA; Galina SIMONOVA; Abdonas TAMOSIUNAS; Martin BOBÁK a Hynek PIKHART. Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study. \textit{Respiratory Research}. ENGLAND: BMC, 2022, roč.~23, č.~1, s.~1-10. ISSN~1465-993X. Dostupné z: https://doi.org/10.1186/s12931-022-02057-y.

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