1996
Degeneration and regeneration of cutaneous sensory nerve formations
DUBOVÝ, Petr a Hakan ALDSKOGIUSZákladní údaje
Originální název
Degeneration and regeneration of cutaneous sensory nerve formations
Název česky
Degenerace a regenerace kožních nervových zakončení
Autoři
DUBOVÝ, Petr a Hakan ALDSKOGIUS
Vydání
Microscopy research and technique, USA, Wiley-Liss, INC. 1996, 1059-910X
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14110/96:00024507
Organizační jednotka
Lékařská fakulta
UT WoS
Klíčová slova anglicky
Collateral sprouting; Dorsal root ganglia; Freezing injury; Merkel cells; Nerve growth factor
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 19. 6. 2009 13:57, prof. RNDr. Petr Dubový, CSc.
V originále
Auxiliary structures of the cutaneous sensory nerve formations (SNF) are dependent on sensory innervation during their critical period of development. Denervation of mature cutaneous corpuscles results in survival of the terminal Schwann cells and the capsular structures which are probably responsible for successful reinnervation of the cutaneous SNF. In addition, the basal lamina tubes of Schwann cells are connected with the terminal Schwann cells and play an important role in the guidance of regrowing axons to their original targets. Long-lasting denervation causes atrophic changes of the terminal Schwann cells and alterations of their molecular equipment. These atrophic changes in the terminal Schwann cells may be responsible for erroneous reinnervation of cutaneous SNF. A population of the cutaneous Merkel cells surviving denervation may also serve as targets for regrowing sensory axons. The basal laminae of terminal Schwann cells are produced under control of the sensory terminals during maturation of cutaneous SNF. In adult animals, the basal laminae are capable of stimulating differentiation of migrated Schwann cells to the terminal Schwann cells without the presence of the sensory terminals. Nonspecific cholinesterase (nChE) is secreted by the terminal Schwann cells and is attached to their extracellular matrix. The synthesis of these molecules in adult animals is not influenced by the sensory terminals. However, the presence of nChE molecules is associated with living terminal Schwann cells. Fetal orthotopically grafted dorsal root ganglion (DRG) neurons have the ability to reinnervate cutaneous SNF of adult hosts. When cutaneous areas are denervated, axons from adjacent sensory nerves may extend collateral branches into this area. The capacity for such extension is dependent on: (1) type of sensory nerve ending, C and Adelta fibers having significantly greater capacity than sensory axons of larger caliber; (2) age of the animal, immature animals generally showing a greater capacity for collateral sprouting; (3) the state of the adjacent axons, those already in a growth mode being more capable than 'resting' ones; and (4) the regional and mechanical conditions at the site of denervation, hindpaw skin being much less extensively reinnervated by collateral fibers than that of the trunk.
Česky
Reinervace kožních somatosenzorických nervových formací probíhá několika způsoby.
Návaznosti
| GA309/93/0134, projekt VaV |
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| GA309/93/0574, projekt VaV |
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