VAŠKŮ, Anna, Miroslav SOUČEK, Dobroslav HÁJEK, Lydie HOLLÁ, Vladimír ZNOJIL and Jiří VÁCHA. Association analysis of 24-h blood pressure records with I/D ACE gene polymorphism and AB0 blood group system. Physiological Research. 1999, vol. 48, No 2, p. 99-104. ISSN 0862-8408.
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Basic information
Original name Association analysis of 24-h blood pressure records with I/D ACE gene polymorphism and AB0 blood group system
Authors VAŠKŮ, Anna (203 Czech Republic, guarantor), Miroslav SOUČEK (203 Czech Republic), Dobroslav HÁJEK (203 Czech Republic), Lydie HOLLÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition Physiological Research, 1999, 0862-8408.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.521
RIV identification code RIV/00216224:14110/99:00000716
Organization unit Faculty of Medicine
UT WoS 000080227700002
Keywords in English circadian blood pressure rhythm; I/D ACE polymorphism; ABO blood group system; sex; body mass index
Tags ABO blood group system, body mass index, circadian blood pressure rhythm, I/D ACE polymorphism, Sex
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 17/6/2009 13:17.
Abstract
The purpose of the study was to analyse associations among 24-h blood pressure records parameters, insertion/deletion angiotensin I converting enzyme gene polymorphism and ABO blood group system in sample of Czech subjects from general population. Eleven parameters describing the 24-h blood pressure readings were obtained from the analysis of the 24-h blood pressure records in 243 volunteers, 119 men and 124 women. Using multivariation analysis of variance, the parameters were adjusted for sex and BMI. All the subjects were genotyped for insertion/deletion angiotensin I converting enzyme (I/D ACE) gene polymorphism. They were examined for the blood group in ABO system routinely. An association between interaction of I/D ACE gene polymorphism and ABO blood group systém on the one side and mean values of systolic (p=0.016), mean arterial (p=0.027) blood pressures and the maximum amplitude position of 24-h BP rhythm (p=0.036) on the other side was found.
Links
GA306/93/2192, research and development projectName: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.
Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
VS96097, research and development projectName: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases
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