Effect of one year antihypertensive therapy with angiotensin I
converting enzyme (ACE) inhibitor on hemodynamic, hematological
and biochemical parameters. Effects of I/D ACE and M235T and
T174M angiotensinogen gene polymorphisms

J 1999

Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms

VAŠKŮ, Anna; Miroslav SOUČEK; Vladimír ZNOJIL; Lada RAMBOUSKOVÁ; Ivan ŘIHÁČEK et al.

Základní údaje

Originální název

Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms

Autoři

VAŠKŮ, Anna; Miroslav SOUČEK; Vladimír ZNOJIL; Lada RAMBOUSKOVÁ; Ivan ŘIHÁČEK; Karel CÍDL; Lenka STŘELCOVÁ a Jiří VÁCHA

Vydání

Scripta medica, Brno, Lékařská fakulta Masarykovy univerzity, 1999, 1211-3395

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/99:00001112

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

quinapril; angiotensin-converting enzyme; angiotensinogen; ambulatory blood pressure monitoring

Štítky

Ambulatory blood pressure monitoring, angiotensin-converting enzyme, angiotensinogen, quinapril

Změněno: 24. 4. 2003 11:04, prof. MUDr. Anna Vašků, CSc.

Anotace

V originále

The purpose of the study has been to evaluate the influence of one year angiotensin I-converting enzyme inhibitor (IACE) treatment on 24-h blood pressure (BP) and heart rate (HR) parameters, other hemodynamic (ECG, ECHO) parameters and hematological and biochemical tests in the genetic context of renin - angiotensin system gene polymorphisms. Eleven newly diagnosed essential hypertensives were treated with ACE inhibitor quinapril (Accupro, Gödecke, Berlin) for one year. All patients were genotyped for three polymorphisms - I/D of angiotensin I-converting enzyme and M235->T and T174->M of angiotensinogen genes, respectively. A decrease in the mean levels of systolic (p=0.001), mean arterial (p=0.002) and diastolic (p=0.003) blood pressures were found. No significant differences in ECG parameters nor differences in ECHO parameters became evident.However, a decrease in the red blood cell count (p=0.004) and an increase in the MCV of the RBCs (p=0.002) were observed. Differences in the blood glucose levels appeared to be associated with I/D ACE genotype (p=0.01).

Návaznosti

GA306/93/2192, projekt VaV

Název: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.

Investor: Grantová agentura ČR, Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

VS96097, projekt VaV

Název: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob

Citovat

VAŠKŮ, Anna; Miroslav SOUČEK; Vladimír ZNOJIL; Lada RAMBOUSKOVÁ; Ivan ŘIHÁČEK; Karel CÍDL; Lenka STŘELCOVÁ a Jiří VÁCHA. Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms. Scripta medica. Brno: Lékařská fakulta Masarykovy univerzity, 1999, roč. 72, 2-3, s. 87-96. ISSN 1211-3395.

@article{207691,
   author = {Vašků, Anna and Souček, Miroslav and Znojil, Vladimír and Rambousková, Lada and Řiháček, Ivan and Cídl, Karel and Střelcová, Lenka and Vácha, Jiří},
   article_location = {Brno},
   article_number = {2-3},
   keywords = {quinapril; angiotensin-converting enzyme; angiotensinogen; ambulatory blood pressure monitoring},
   language = {eng},
   issn = {1211-3395},
   journal = {Scripta medica},
   title = {Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms},
   volume = {72},
   year = {1999}
}

TY  - JOUR
ID  - 207691
AU  - Vašků, Anna - Souček, Miroslav - Znojil, Vladimír - Rambousková, Lada - Řiháček, Ivan - Cídl, Karel - Střelcová, Lenka - Vácha, Jiří
PY  - 1999
TI  - Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms
JF  - Scripta medica
VL  - 72
IS  - 2-3
SP  - 87
EP  - 87
PB  - Lékařská fakulta Masarykovy univerzity
SN  - 12113395
KW  - quinapril
KW  - angiotensin-converting enzyme
KW  - angiotensinogen
KW  - ambulatory blood pressure monitoring
N2  - The purpose of the study has been to evaluate the influence of one year angiotensin I-converting enzyme inhibitor (IACE) treatment on 24-h blood pressure (BP) and heart rate (HR) parameters, other hemodynamic (ECG, ECHO) parameters and hematological and biochemical tests in the genetic context of renin - angiotensin system gene polymorphisms. Eleven newly diagnosed essential hypertensives were treated with ACE inhibitor quinapril (Accupro, Gödecke, Berlin) for one year. All patients were genotyped for three polymorphisms - I/D of angiotensin I-converting enzyme and M235->T and T174->M of angiotensinogen genes, respectively. A decrease in the mean levels of systolic (p=0.001), mean arterial (p=0.002) and diastolic (p=0.003) blood pressures were found. No significant differences in ECG parameters nor differences in ECHO parameters became evident.However, a decrease in the red blood cell count (p=0.004) and an increase in the MCV of the RBCs (p=0.002) were observed. Differences in the blood glucose levels appeared to be associated with I/D ACE genotype (p=0.01).
ER  -

VAŠKŮ, Anna; Miroslav SOUČEK; Vladimír ZNOJIL; Lada RAMBOUSKOVÁ; Ivan ŘIHÁČEK; Karel CÍDL; Lenka STŘELCOVÁ a Jiří VÁCHA. Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms. \textit{Scripta medica}. Brno: Lékařská fakulta Masarykovy univerzity, 1999, roč.~72, 2-3, s.~87-96. ISSN~1211-3395.

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