| VAŠKŮ, Anna, Miroslav SOUČEK, Vladimír ZNOJIL, Lada RAMBOUSKOVÁ, Ivan ŘIHÁČEK, Karel CÍDL, Lenka STŘELCOVÁ a Jiří VÁCHA. Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms. Scripta medica. Brno: Lékařská fakulta Masarykovy univerzity, 1999, roč. 72, 2-3, s. 87-96. ISSN 1211-3395. |
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@article{207691,
author = {Vašků, Anna and Souček, Miroslav and Znojil, Vladimír and Rambousková, Lada and Řiháček, Ivan and Cídl, Karel and Střelcová, Lenka and Vácha, Jiří},
article_location = {Brno},
article_number = {2-3},
keywords = {quinapril; angiotensin-converting enzyme; angiotensinogen; ambulatory blood pressure monitoring},
language = {eng},
issn = {1211-3395},
journal = {Scripta medica},
title = {Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms},
volume = {72},
year = {1999}
}
TY - JOUR
ID - 207691
AU - Vašků, Anna - Souček, Miroslav - Znojil, Vladimír - Rambousková, Lada - Řiháček, Ivan - Cídl, Karel - Střelcová, Lenka - Vácha, Jiří
PY - 1999
TI - Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms
JF - Scripta medica
VL - 72
IS - 2-3
SP - 87
EP - 87
PB - Lékařská fakulta Masarykovy univerzity
SN - 12113395
KW - quinapril
KW - angiotensin-converting enzyme
KW - angiotensinogen
KW - ambulatory blood pressure monitoring
N2 - The purpose of the study has been to evaluate the influence of one year angiotensin I-converting enzyme inhibitor (IACE) treatment on 24-h blood pressure (BP) and heart rate (HR) parameters, other hemodynamic (ECG, ECHO) parameters and hematological and biochemical tests in the genetic context of renin - angiotensin system gene polymorphisms. Eleven newly diagnosed essential hypertensives were treated with ACE inhibitor quinapril (Accupro, Gödecke, Berlin) for one year. All patients were genotyped for three polymorphisms - I/D of angiotensin I-converting enzyme and M235->T and T174->M of angiotensinogen genes, respectively. A decrease in the mean levels of systolic (p=0.001), mean arterial (p=0.002) and diastolic (p=0.003) blood pressures were found. No significant differences in ECG parameters nor differences in ECHO parameters became evident.However, a decrease in the red blood cell count (p=0.004) and an increase in the MCV of the RBCs (p=0.002) were observed. Differences in the blood glucose levels appeared to be associated with I/D ACE genotype (p=0.01).
ER -
VAŠKŮ, Anna, Miroslav SOUČEK, Vladimír ZNOJIL, Lada RAMBOUSKOVÁ, Ivan ŘIHÁČEK, Karel CÍDL, Lenka STŘELCOVÁ a Jiří VÁCHA. Effect of one year antihypertensive therapy with angiotensin I converting enzyme (ACE) inhibitor on hemodynamic, hematological and biochemical parameters. Effects of I/D ACE and M235T and T174M angiotensinogen gene polymorphisms. \textit{Scripta medica}. Brno: Lékařská fakulta Masarykovy univerzity, 1999, roč.~72, 2-3, s.~87-96. ISSN~1211-3395.
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