| ŠTIKA, Jiří, Jiřina HOFMANOVÁ, Karel SOUČEK, Jan VONDRÁČEK, Vladimír ŠIMEK a Alois KOZUBÍK. Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration. In Cells. České Budějovice: Nakladatelství Koop, Czech Republic, 1999, s. 131. 15th Biological Days. ISBN 80-7232-069-6. |
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@inproceedings{219451,
author = {Štika, Jiří and Hofmanová, Jiřina and Souček, Karel and Vondráček, Jan and Šimek, Vladimír and Kozubík, Alois},
address = {České Budějovice},
booktitle = {Cells},
language = {eng},
location = {České Budějovice},
isbn = {80-7232-069-6},
pages = {131-131},
publisher = {Nakladatelství Koop, Czech Republic},
title = {Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration},
year = {1999}
}
TY - JOUR
ID - 219451
AU - Štika, Jiří - Hofmanová, Jiřina - Souček, Karel - Vondráček, Jan - Šimek, Vladimír - Kozubík, Alois
PY - 1999
TI - Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration
VL - 15th Biological Days
PB - Nakladatelství Koop, Czech Republic
CY - České Budějovice
SN - 8072320696
N2 - TPA is known activator of protein kinase C. This activation subsequently reduces proliferation and induces differentiation and apoptosis of human myeloid leukaemia cell line HL-60. We have studied possible role of arachidonic acid metabolites in these processes. The reduction of proliferation and the induction of differentiation were not influenced either by indomethacin or MK-886. While indomethacin did not affect the percentage of apoptotic cells, MK-886 combined with TPA significantly enhanced the amount of apoptotic cells in concentration in which MK-886 alone did not induce apoptosis. Assuming that the enhancement of apoptosis by MK-886 was caused by 5-LPO inhibition, blocking the 5-LPO activity could contribute to leukaemia treatment.
ER -
ŠTIKA, Jiří, Jiřina HOFMANOVÁ, Karel SOUČEK, Jan VONDRÁČEK, Vladimír ŠIMEK a Alois KOZUBÍK. Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration. In \textit{Cells}. České Budějovice: Nakladatelství Koop, Czech Republic, 1999, s.~131. 15th Biological Days. ISBN~80-7232-069-6.
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