Role of Arachidonic Acid Metabolites in Proliferation,
Differentiation and Apoptosis on Human Leukaemic Cell Line
HL-60 after TPA Administration

D 1999

Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration

ŠTIKA, Jiří; Jiřina HOFMANOVÁ; Karel SOUČEK; Jan VONDRÁČEK; Vladimír ŠIMEK et al.

Základní údaje

Originální název

Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration

Autoři

ŠTIKA, Jiří ; Jiřina HOFMANOVÁ; Karel SOUČEK; Jan VONDRÁČEK; Vladimír ŠIMEK a Alois KOZUBÍK

Vydání

České Budějovice, Cells, s. 131-131, 15th Biological Days, 1999

Nakladatel

Nakladatelství Koop, Czech Republic

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/99:00001303

Organizační jednotka

Přírodovědecká fakulta

ISBN

80-7232-069-6

Změněno: 8. 1. 2002 13:48, Mgr. Jiří Štika, Ph.D.

Anotace

V originále

TPA is known activator of protein kinase C. This activation subsequently reduces proliferation and induces differentiation and apoptosis of human myeloid leukaemia cell line HL-60. We have studied possible role of arachidonic acid metabolites in these processes. The reduction of proliferation and the induction of differentiation were not influenced either by indomethacin or MK-886. While indomethacin did not affect the percentage of apoptotic cells, MK-886 combined with TPA significantly enhanced the amount of apoptotic cells in concentration in which MK-886 alone did not induce apoptosis. Assuming that the enhancement of apoptosis by MK-886 was caused by 5-LPO inhibition, blocking the 5-LPO activity could contribute to leukaemia treatment.

Návaznosti

GA524/99/0694, projekt VaV

Název: Vysoce nenasycené mastné kyseliny a cytokiny - jejich úloha pro zachování homeostázy na úrovni buněčných populací

Citovat

ŠTIKA, Jiří; Jiřina HOFMANOVÁ; Karel SOUČEK; Jan VONDRÁČEK; Vladimír ŠIMEK a Alois KOZUBÍK. Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration. In Cells. České Budějovice: Nakladatelství Koop, Czech Republic, 1999, s. 131. 15th Biological Days. ISBN 80-7232-069-6.

@inproceedings{219451,
   author = {Štika, Jiří and Hofmanová, Jiřina and Souček, Karel and Vondráček, Jan and Šimek, Vladimír and Kozubík, Alois},
   address = {České Budějovice},
   booktitle = {Cells},
   language = {eng},
   location = {České Budějovice},
   isbn = {80-7232-069-6},
   pages = {131-131},
   publisher = {Nakladatelství Koop, Czech Republic},
   title = {Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration},
   year = {1999}
}

TY  - CONF
ID  - 219451
AU  - Štika, Jiří - Hofmanová, Jiřina - Souček, Karel - Vondráček, Jan - Šimek, Vladimír - Kozubík, Alois
PY  - 1999
TI  - Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration
VL  - 15th Biological Days
PB  - Nakladatelství Koop, Czech Republic
CY  - České Budějovice
SN  - 8072320696
N2  - TPA is known activator of protein kinase C. This activation subsequently reduces proliferation and induces differentiation and apoptosis of human myeloid leukaemia cell line HL-60. We have studied possible role of arachidonic acid metabolites in these processes. The reduction of proliferation and the induction of differentiation were not influenced either by indomethacin or MK-886. While indomethacin did not affect the percentage of apoptotic cells, MK-886 combined with TPA significantly enhanced the amount of apoptotic cells in concentration in which MK-886 alone did not induce apoptosis. Assuming that the enhancement of apoptosis by MK-886 was caused by 5-LPO inhibition, blocking the 5-LPO activity could contribute to leukaemia treatment.
ER  -

ŠTIKA, Jiří; Jiřina HOFMANOVÁ; Karel SOUČEK; Jan VONDRÁČEK; Vladimír ŠIMEK a Alois KOZUBÍK. Role of Arachidonic Acid Metabolites in Proliferation, Differentiation and Apoptosis on Human Leukaemic Cell Line HL-60 after TPA Administration. In \textit{Cells}. České Budějovice: Nakladatelství Koop, Czech Republic, 1999, s.~131. 15th Biological Days. ISBN~80-7232-069-6.

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