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@article{2210841,
author = {Smetana, Jan and Brož, Petr},
article_number = {3},
doi = {http://dx.doi.org/10.3390/genes13030556},
keywords = {national genome project; whole-genome sequencing; population; genetic variability Europe; United Kingdom},
language = {eng},
issn = {2073-4425},
journal = {Genes},
title = {National Genome Initiatives in Europe and the United Kingdom in the Era of Whole-Genome Sequencing: A Comprehensive Review},
url = {https://www.mdpi.com/2073-4425/13/3/556},
volume = {13},
year = {2022}
}
TY - JOUR
ID - 2210841
AU - Smetana, Jan - Brož, Petr
PY - 2022
TI - National Genome Initiatives in Europe and the United Kingdom in the Era of Whole-Genome Sequencing: A Comprehensive Review
JF - Genes
VL - 13
IS - 3
SP - 1-12
EP - 1-12
PB - MDPI
SN - 20734425
KW - national genome project
KW - whole-genome sequencing
KW - population
KW - genetic variability Europe
KW - United Kingdom
UR - https://www.mdpi.com/2073-4425/13/3/556
N2 - Identification of genomic variability in population plays an important role in the clinical diagnostics of human genetic diseases. Thanks to rapid technological development in the field of massive parallel sequencing technologies, also known as next-generation sequencing (NGS), complex genomic analyses are now easier and cheaper than ever before, which consequently leads to more effective utilization of these techniques in clinical practice. However, interpretation of data from NGS is still challenging due to several issues caused by natural variability of DNA sequences in human populations. Therefore, development and realization of projects focused on description of genetic variability of local population (often called "national or digital genome") with a NGS technique is one of the best approaches to address this problem. The next step of the process is to share such data via publicly available databases. Such databases are important for the interpretation of variants with unknown significance or (likely) pathogenic variants in rare diseases or cancer or generally for identification of pathological variants in a patient's genome. In this paper, we have compiled an overview of published results of local genome sequencing projects from United Kingdom and Europe together with future plans and perspectives for newly announced ones.
ER -
SMETANA, Jan a Petr BROŽ. National Genome Initiatives in Europe and the United Kingdom in the Era of Whole-Genome Sequencing: A Comprehensive Review. \textit{Genes}. MDPI, 2022, roč.~13, č.~3, s.~1-12. ISSN~2073-4425. Dostupné z: https://dx.doi.org/10.3390/genes13030556.
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