Candida dubliniensis and Candida albicans associated with early
childhood caries in preschool children - a case-control study

a 2022

Candida dubliniensis and Candida albicans associated with early childhood caries in preschool children - a case-control study

CVANOVÁ, Michaela, Filip RŮŽIČKA, Martina KUKLETOVÁ, Břetislav LIPOVÝ, Daniela GACHOVÁ et. al.

Základní údaje

Originální název

Candida dubliniensis and Candida albicans associated with early childhood caries in preschool children - a case-control study

Autoři

CVANOVÁ, Michaela (203 Česká republika), Filip RŮŽIČKA (203 Česká republika), Martina KUKLETOVÁ (203 Česká republika), Břetislav LIPOVÝ (203 Česká republika), Daniela GACHOVÁ (203 Česká republika), Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika), Zdeněk DANĚK (203 Česká republika), Veronika HOLÁ (203 Česká republika), Michaela BARTOŠOVÁ (703 Slovensko), Jiří JARKOVSKÝ (203 Česká republika), Ladislav DUŠEK (203 Česká republika) a Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, garant, domácí)

Vydání

ESPID 2022, 2022

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/22:00126401

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

candida; infectious; children; caries

Změněno: 30. 3. 2023 10:55, Mgr. Terezie Slámová

Anotace

V originále

Backgrounds: Dental caries is the worldwide most common infectious disease within the oral cavity. Caries in the primary dentition is referred to as Early Childhood Caries (ECC) and is associated with the presence of oral cariogenic bacteria. The role of other oral candidas in the ECC development is not fully understood. Our study aimed to investigate the occurrence of Candida sp. in preschool children according to their oral status. Methods: In this case-control association study, samples of dental plaque were collected from 164 children with ECC (with 6 or more of decayed,missed or filled teeth) and 147 children without dental caries. MALDI-TOF mass spectroscopy was used to identify Candida sp. Results: In all, 12 Candida sp. were identified in our study group. The occurrence of Candida sp. was significantly associated with sECC (odds ratio, OR 11.40, p < 0.001). The strongest association was with C. dubliniensis (OR 13.50, p < 0.001) and C. albicans (OR 6.83, p < 0.001). Conclusions/Learning Points: The presence of C. dubliniensis and C. albicans in dental plaque is an important indicator of dental caries development in preschool children. This research was supported by Ministry of Health of the Czech Republic, grant number: IGA NR8394-3/2005, NV17-30439A, NU20-08-00205, and by a project provided by University Hospital Brno, Ministry of Health Czech Republic – RVO (FNBr, 65269705). This publication has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 857560. Authors also thank the Research Infrastructure RECETOX RI (No LM2018121) and project CETOCOEN EXCELLENCE (No CZ.02.1.01/0.0/0.0/17_043/0009632) financed by the Ministry of Education, Youth and Sports for supportive background.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LM2018121, projekt VaV

Název: Výzkumná infrastruktura RECETOX (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI

NR8394, projekt VaV

Název: Stav orálního zdraví u dětí sledovaných v programu ELSPAC Brno

Investor: Ministerstvo zdravotnictví ČR, Stav orálního zdraví u dětí sledovaných v programu ELSPAC Brno

NU20-08-00205, projekt VaV

Název: Molekulární etiopatogeneze apikální periodontitidy a odontogenních cyst

Investor: Ministerstvo zdravotnictví ČR, Molekulární etiopatogeneze apikální periodontitidy a odontogenních cyst, Podprogram 1 - standardní

NV17-30439A, projekt VaV

Název: Moderní biotechnologické a behaviorální přístupy ve výzkumu zubního kazu a strategie jeho prevence

Citovat

CVANOVÁ, Michaela, Filip RŮŽIČKA, Martina KUKLETOVÁ, Břetislav LIPOVÝ, Daniela GACHOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Zdeněk DANĚK, Veronika HOLÁ, Michaela BARTOŠOVÁ, Jiří JARKOVSKÝ, Ladislav DUŠEK a Petra BOŘILOVÁ LINHARTOVÁ. Candida dubliniensis and Candida albicans associated with early childhood caries in preschool children - a case-control study. In ESPID 2022. 2022.

@proceedings{2210899,
   author = {Cvanová, Michaela and Růžička, Filip and Kukletová, Martina and Lipový, Břetislav and Gachová, Daniela and Izakovičová Hollá, Lydie and Daněk, Zdeněk and Holá, Veronika and Bartošová, Michaela and Jarkovský, Jiří and Dušek, Ladislav and Bořilová Linhartová, Petra},
   booktitle = {ESPID 2022},
   keywords = {candida; infectious; children; caries},
   language = {eng},
   title = {Candida dubliniensis and Candida albicans associated with early childhood caries in preschool children - a case-control study},
   year = {2022}
}

TY  - CONF
ID  - 2210899
AU  - Cvanová, Michaela - Růžička, Filip - Kukletová, Martina - Lipový, Břetislav - Gachová, Daniela - Izakovičová Hollá, Lydie - Daněk, Zdeněk - Holá, Veronika - Bartošová, Michaela - Jarkovský, Jiří - Dušek, Ladislav - Bořilová Linhartová, Petra
PY  - 2022
TI  - Candida dubliniensis and Candida albicans associated with early childhood caries in preschool children - a case-control study
KW  - candida
KW  - infectious
KW  - children
KW  - caries
N2  - Backgrounds: Dental caries is the worldwide most common infectious disease within the oral cavity. Caries in the primary dentition is referred to as Early Childhood Caries (ECC) and is associated with the presence of oral cariogenic bacteria. The role of other oral candidas in the ECC development is not fully understood. Our study aimed to investigate the occurrence of Candida sp. in preschool children according to their oral status. Methods: In this case-control association study, samples of dental plaque were collected from 164 children with ECC (with 6 or more of decayed,missed or filled teeth) and 147 children without dental caries. MALDI-TOF mass spectroscopy was used to identify Candida sp. Results: In all, 12 Candida sp. were identified in our study group. The occurrence of Candida sp. was significantly associated with sECC (odds ratio, OR 11.40, p < 0.001). The strongest association was with C. dubliniensis (OR 13.50, p < 0.001) and C. albicans (OR 6.83, p < 0.001). Conclusions/Learning Points: The presence of C. dubliniensis and C. albicans in dental plaque is an important indicator of dental caries development in preschool children. This research was supported by Ministry of Health of the Czech Republic, grant number: IGA NR8394-3/2005, NV17-30439A, NU20-08-00205, and by a project provided by University Hospital Brno, Ministry of Health Czech Republic – RVO (FNBr, 65269705). This publication has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 857560. Authors also thank the Research Infrastructure RECETOX RI (No LM2018121) and project CETOCOEN EXCELLENCE (No CZ.02.1.01/0.0/0.0/17_043/0009632) financed by the Ministry of Education, Youth and Sports for supportive background.
ER  -

Podrobný výpis o publikaci