The reduction of hippocampal volume in Parkinson's disease

J 2022

The reduction of hippocampal volume in Parkinson's disease

ŘÍHA, Pavel; Luboš BRABENEC; Radek MAREČEK; Ivan REKTOR; Irena REKTOROVÁ et. al.

Základní údaje

Originální název

The reduction of hippocampal volume in Parkinson's disease

Autoři

ŘÍHA, Pavel; Luboš BRABENEC; Radek MAREČEK; Ivan REKTOR a Irena REKTOROVÁ

Vydání

Journal of Neural Transmission, WIEN, SPRINGER WIEN, 2022, 0300-9564

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.300

Kód RIV

RIV/00216224:14740/22:00126466

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1007/s00702-021-02451-8

UT WoS

000751224300001

EID Scopus

2-s2.0-85124293730

Klíčová slova anglicky

Parkinson's disease; Aging; Hippocampus-to-cortex volume ratio; Processing speed

Štítky

14110127, CF MAFIL, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 10. 2024 09:57, Ing. Jana Kuchtová

Anotace

V originále

The volume of the hippocampus decreases more slowly than the volume of the cortex during normal aging. We explored changes in the hippocampus-to-cortex volume (HV:CTV) ratio with increasing age in non-demented Parkinson's disease (PD) patients as compared to healthy controls (HC). We also evaluated the association between the HV:CTV ratio and cognitive outcomes. Altogether 130 participants without dementia aged 51-88 years were consecutively enrolled, including 54 PD patients (mean age 67, standard deviation (SD) 8 years) and 76 HC (mean age 69, SD 7 years). All participants underwent structural magnetic resonance examination and psychological evaluation. Hippocampal and cortex volumes were determined from T1 and FLAIR scans using FreeSurfer software, and the HV:CTV ratio was calculated. Regression lines for age-dependence of the HV:CTV ratio for PD and HC groups were calculated. We further assessed the association between the HV:CTV ratio and cognitive tests examining hippocampus-related cognitive functions. PD patients and age-matched HC showed a significant difference in age-dependence of HV:CTV ratio (p value = 0.012), with a decreasing slope in PD and increasing slope in HC. In the PD group, a significant correlation (R = 0.561, p = 0.024) was observed between the HV:CTV ratio and the Digit Symbol-Coding test. The reduction of HV:CTV ratio is accelerated in pathological aging due to PD pathology. The HV:CTV ratio was associated with impaired processing speed, i.e., the cognitive function that is linked to subcortical alterations of both associated basal ganglia circuitry and the hippocampus.

Návaznosti

GA21-25953S, projekt VaV

Název: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Akronym: DBS3D)

Investor: Grantová agentura ČR, Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace

NU20-04-00294, projekt VaV

Název: Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

Investor: Ministerstvo zdravotnictví ČR, Diagnostika onemocnění s Lewyho tělísky v prodromálním stadiu založená na analýze multimodálních dat

734718, interní kód MU

Název: Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology (Akronym: CoBeN)

Investor: Evropská unie, Novel Network-Based Approaches for Studying Cognitive Dysfunction in Behavioral Neurology, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

90129, velká výzkumná infrastruktura

Název: Czech-BioImaging II

Citovat

ŘÍHA, Pavel; Luboš BRABENEC; Radek MAREČEK; Ivan REKTOR a Irena REKTOROVÁ. The reduction of hippocampal volume in Parkinson's disease. Journal of Neural Transmission. WIEN: SPRINGER WIEN, 2022, roč. 129, 5-6, s. 575-580. ISSN 0300-9564. Dostupné z: https://doi.org/10.1007/s00702-021-02451-8.

@article{2212070,
   author = {Říha, Pavel and Brabenec, Luboš and Mareček, Radek and Rektor, Ivan and Rektorová, Irena},
   article_location = {WIEN},
   article_number = {5-6},
   doi = {https://doi.org/10.1007/s00702-021-02451-8},
   keywords = {Parkinson's disease; Aging; Hippocampus-to-cortex volume ratio; Processing speed},
   language = {eng},
   issn = {0300-9564},
   journal = {Journal of Neural Transmission},
   title = {The reduction of hippocampal volume in Parkinson's disease},
   url = {https://link.springer.com/article/10.1007/s00702-021-02451-8},
   volume = {129},
   year = {2022}
}

TY  - JOUR
ID  - 2212070
AU  - Říha, Pavel - Brabenec, Luboš - Mareček, Radek - Rektor, Ivan - Rektorová, Irena
PY  - 2022
TI  - The reduction of hippocampal volume in Parkinson's disease
JF  - Journal of Neural Transmission
VL  - 129
IS  - 5-6
SP  - 575-580
EP  - 575-580
PB  - SPRINGER WIEN
SN  - 03009564
KW  - Parkinson's disease
KW  - Aging
KW  - Hippocampus-to-cortex volume ratio
KW  - Processing speed
UR  - https://link.springer.com/article/10.1007/s00702-021-02451-8
N2  - The volume of the hippocampus decreases more slowly than the volume of the cortex during normal aging. We explored changes in the hippocampus-to-cortex volume (HV:CTV) ratio with increasing age in non-demented Parkinson's disease (PD) patients as compared to healthy controls (HC). We also evaluated the association between the HV:CTV ratio and cognitive outcomes. Altogether 130 participants without dementia aged 51-88 years were consecutively enrolled, including 54 PD patients (mean age 67, standard deviation (SD) 8 years) and 76 HC (mean age 69, SD 7 years). All participants underwent structural magnetic resonance examination and psychological evaluation. Hippocampal and cortex volumes were determined from T1 and FLAIR scans using FreeSurfer software, and the HV:CTV ratio was calculated. Regression lines for age-dependence of the HV:CTV ratio for PD and HC groups were calculated. We further assessed the association between the HV:CTV ratio and cognitive tests examining hippocampus-related cognitive functions. PD patients and age-matched HC showed a significant difference in age-dependence of HV:CTV ratio (p value = 0.012), with a decreasing slope in PD and increasing slope in HC. In the PD group, a significant correlation (R = 0.561, p = 0.024) was observed between the HV:CTV ratio and the Digit Symbol-Coding test. The reduction of HV:CTV ratio is accelerated in pathological aging due to PD pathology. The HV:CTV ratio was associated with impaired processing speed, i.e., the cognitive function that is linked to subcortical alterations of both associated basal ganglia circuitry and the hippocampus.
ER  -

ŘÍHA, Pavel; Luboš BRABENEC; Radek MAREČEK; Ivan REKTOR a Irena REKTOROVÁ. The reduction of hippocampal volume in Parkinson's disease. \textit{Journal of Neural Transmission}. WIEN: SPRINGER WIEN, 2022, roč.~129, 5-6, s.~575-580. ISSN~0300-9564. Dostupné z: https://doi.org/10.1007/s00702-021-02451-8.

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