NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT
ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND
XII INHIBITORS

D 2022

NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS

HAVRÁNKOVÁ, Eva; Josef JAMPÍLEK; Vladimír GARAJ a Claudiu T. SUPURAN

Základní údaje

Originální název

NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS

Autoři

HAVRÁNKOVÁ, Eva ; Josef JAMPÍLEK; Vladimír GARAJ a Claudiu T. SUPURAN

Vydání

Prague, Czech republic, Czech Chemical Society Symposium Series, od s. 14-15, 2 s. 2022

Nakladatel

Czech Chemical Society

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30107 Medicinal chemistry

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

elektronická verze "online"

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14160/22:00126647

Organizační jednotka

Farmaceutická fakulta

ISSN

Klíčová slova anglicky

carbonic anhydrases; vancomycin-resistant enterococci; anti-VRE agents; triazinyl-benzenesulfonamides

Příznaky

Recenzováno

Změněno: 13. 9. 2022 14:00, RNDr. Eva Havránková, Ph.D.

Anotace

V originále

Carbonic anhydrases (CA, EC 4.2.1.1) are metallo-enzymes present in various organisms. In pathogenic bacteria, CAs play an important role in growth and survival. Inhibition of bacterial CAs leads to growth defects, growth retardation and makes bacterias vulnerable to host defense mechanisms. Bacterial CAs are therefore a very promising target in the search for new antibiotics. A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs were synthesized as potential bacterial CAs inhibitors. Newly prepared compounds have a great potential as antibacterial agents with high activity and at the same time with high selectivity for bacterial CA in comparison with metabolically important hCA isoenzymes (e.g. hCA I, hCA II) found in the human body.

Návaznosti

MUNI/A/1202/2020, interní kód MU

Název: Syntéza nových potenciálních inhibitorů CA

Investor: Masarykova univerzita, Syntéza nových potenciálních inhibitorů CA

Citovat

HAVRÁNKOVÁ, Eva; Josef JAMPÍLEK; Vladimír GARAJ a Claudiu T. SUPURAN. NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS. Online. In Radmila Řápková, Martin Fusek, Pavel Drašar. Czech Chemical Society Symposium Series. Prague, Czech republic: Czech Chemical Society, 2022, s. 14-15. ISSN 2336-7210.

@inproceedings{2217366,
   author = {Havránková, Eva and Jampílek, Josef and Garaj, Vladimír and Supuran, Claudiu T.},
   address = {Prague, Czech republic},
   booktitle = {Czech Chemical Society Symposium Series},
   editor = {Radmila Řápková, Martin Fusek, Pavel Drašar},
   keywords = {carbonic anhydrases; vancomycin-resistant enterococci; anti-VRE agents; triazinyl-benzenesulfonamides},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Prague, Czech republic},
   pages = {14-15},
   publisher = {Czech Chemical Society},
   title = {NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS},
   url = {http://www.ccsss.cz/index.php/ccsss/issue/view/31/45},
   year = {2022}
}

TY  - CONF
ID  - 2217366
AU  - Havránková, Eva - Jampílek, Josef - Garaj, Vladimír - Supuran, Claudiu T.
PY  - 2022
TI  - NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS
PB  - Czech Chemical Society
CY  - Prague, Czech republic
KW  - carbonic anhydrases
KW  - vancomycin-resistant enterococci
KW  - anti-VRE agents
KW  - triazinyl-benzenesulfonamides
UR  - http://www.ccsss.cz/index.php/ccsss/issue/view/31/45
N2  - Carbonic anhydrases (CA, EC 4.2.1.1) are metallo-enzymes present in various organisms. In pathogenic bacteria, CAs play an important role in growth and survival. Inhibition of bacterial CAs leads to growth defects, growth retardation and makes bacterias vulnerable to host defense mechanisms. Bacterial CAs are therefore a very promising target in the search for new antibiotics. A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs were synthesized as potential bacterial CAs inhibitors. Newly prepared compounds have a great potential as antibacterial agents with high activity and at the same time with high selectivity for bacterial CA in comparison with metabolically important hCA isoenzymes (e.g. hCA I, hCA II) found in the human body.
ER  -

HAVRÁNKOVÁ, Eva; Josef JAMPÍLEK; Vladimír GARAJ a Claudiu T. SUPURAN. NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS. Online. In Radmila Řápková, Martin Fusek, Pavel Drašar. \textit{Czech Chemical Society Symposium Series}. Prague, Czech republic: Czech Chemical Society, 2022, s.~14-15. ISSN~2336-7210.

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