Interaction of five gene polymorphism at psoriasis

VAŠKŮ, Vladimír, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ, Kateřina KAŇKOVÁ, Vladimír ZNOJIL, Věra SEMRÁDOVÁ and Jiří VÁCHA. Interaction of five gene polymorphism at psoriasis. The Journal of Investigative Dermatology. Cambridge: Blackwell Science Inc., 1999, vol. 113, No 3, p. 494. ISSN 0022-202X.

Basic information

• Original name: Interaction of five gene polymorphism at psoriasis
• Authors: VAŠKŮ, Vladimír (203 Czech Republic, guarantor), Anna VAŠKŮ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Kateřina KAŇKOVÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic), Věra SEMRÁDOVÁ (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
• Edition: The Journal of Investigative Dermatology, Cambridge, Blackwell Science Inc. 1999, 0022-202X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30216 Dermatology and venereal diseases
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 4.903
• RIV identification code: RIV/00216224:14110/99:00002134
• Organization unit: Faculty of Medicine
• UT WoS: 000082406000405
• Keywords in English: gene; polymorphism; TAP; TNF; endothelin; ACE
• Tags: ACE, endothelin, gene, polymorphism, TAP, TNF

Abstract

Associations among five gene polymorphism interactions and clinically manifested psoriasis were studied. All studied gene polymorphisms (endothelin-1-ET-1, transporters associated with antigen processing-TAP1, tumor necrosis factor beta-TNF beta, angiotensin I converting enzyme-ACE, advanced glycosylation end product-specific receptor- RAGE) were analyzed for their possible participation in the MHC class I cell surface antigen presentation to CD8+ T-cells. In psoriatic patients (n=153), the disequilibrium was found for coincidence of TNF beta with TAPl-333 ( P=0.016) as well as with TAP1-637 ( P=0.035). TNF beta was in disequilibrium with (ACE) polymorphism (P=0.036). ACE was observed to be in tight disequilibrium with TAP1-333 (p= 0.009) but not with TAP1-637 (P=0.133). The borderline significance of disequilibrium was found for ET-1 and RAGE gene polymorphisms (P=0.07).

Links

• GA306/93/2192, research and development project: Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.

Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension

• GA306/96/0099, research and development project: Name: Polymorfismus genu pro endotelin - 1 (EDN 1) u esenciální hypertense

Investor: Czech Science Foundation, Polymorphism of endothelin - 1 gene (EDN 1) in essential hypertension

• MSM 141100002, plan (intention): Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

• VS96097, research and development project: Name: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases