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@article{2223869,
author = {Bartečků, Elis and Hořínková, Jana and Křenek, Pavel and Damborská, Alena and Tomandl, Josef and Tomandlová, Marie and Kučera, Jan and Kučerová, Jana and Dobrovolná, Julie},
article_location = {LAUSANNE},
article_number = {August 2022},
doi = {http://dx.doi.org/10.3389/fpsyt.2022.893012},
keywords = {osteocalcin; major depressive disorder; biomarker; depression; antidepressant treatment},
language = {eng},
issn = {1664-0640},
journal = {Frontiers in Psychiatry},
title = {Osteocalcin levels decrease during the treatment of an acute depressive episode},
url = {https://www.frontiersin.org/articles/10.3389/fpsyt.2022.893012/full},
volume = {13},
year = {2022}
}
TY - JOUR
ID - 2223869
AU - Bartečků, Elis - Hořínková, Jana - Křenek, Pavel - Damborská, Alena - Tomandl, Josef - Tomandlová, Marie - Kučera, Jan - Kučerová, Jana - Dobrovolná, Julie
PY - 2022
TI - Osteocalcin levels decrease during the treatment of an acute depressive episode
JF - Frontiers in Psychiatry
VL - 13
IS - August 2022
SP - 1-8
EP - 1-8
PB - FRONTIERS MEDIA SA
SN - 16640640
KW - osteocalcin
KW - major depressive disorder
KW - biomarker
KW - depression
KW - antidepressant treatment
UR - https://www.frontiersin.org/articles/10.3389/fpsyt.2022.893012/full
N2 - ObjectivesOsteocalcin is a protein secreted by osteoblasts with a versatile endocrine role. Several domains in which it plays a role-stress response, monoamine synthesis, and cognitive functioning-are implicated also in the pathophysiology of major depressive disorder. In search of possible objective biomarkers of depression, the aim of the study was to assess the relationship between osteocalcin and depressive symptoms during the treatment of depressive episode. MethodsThe study included female inpatients with at least moderate depressive episode. In these patients, depression severity was measured using the Montgomery-angstrom sberg Depression Rating Scale (MADRS), and osteocalcin levels were assessed before the stabilization of antidepressive treatment and after 6 weeks. Relationships between osteocalcin levels and symptoms were analyzed with mixed-effect and linear models, taking into account age, menopausal status, and body mass index. ResultsIn 11 out of 13 enrolled inpatients, osteocalcin levels decreased during the first 6 weeks of treatment; this decrease was significant according to the mixed-effects model (t = -2.345, p = 0.019). According to the linear model, this decrease was significantly associated with reduction in depressive symptom severity (t = 2.673, p = 0.028). Osteocalcin was not associated with initial depressive symptom severity, and initial osteocalcin levels did not predict response to treatment. Limitations of the study include low sample size and inclusion of both pre- and postmenopausal women of various ages. ConclusionsThis preliminary study suggests that osteocalcin may be a candidate biomarker of antidepressive treatment response and that this topic warrants further investigation.
ER -
BARTEČKŮ, Elis, Jana HOŘÍNKOVÁ, Pavel KŘENEK, Alena DAMBORSKÁ, Josef TOMANDL, Marie TOMANDLOVÁ, Jan KUČERA, Jana KUČEROVÁ a Julie DOBROVOLNÁ. Osteocalcin levels decrease during the treatment of an acute depressive episode. \textit{Frontiers in Psychiatry}. LAUSANNE: FRONTIERS MEDIA SA, 2022, roč.~13, August 2022, s.~1-8. ISSN~1664-0640. Dostupné z: https://dx.doi.org/10.3389/fpsyt.2022.893012.
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