2022
Osteocalcin levels decrease during the treatment of an acute depressive episode
BARTEČKŮ, Elis, Jana HOŘÍNKOVÁ, Pavel KŘENEK, Alena DAMBORSKÁ, Josef TOMANDL et. al.Základní údaje
Originální název
Osteocalcin levels decrease during the treatment of an acute depressive episode
Autoři
BARTEČKŮ, Elis (203 Česká republika, domácí), Jana HOŘÍNKOVÁ (203 Česká republika, garant, domácí), Pavel KŘENEK (203 Česká republika, domácí), Alena DAMBORSKÁ (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí), Marie TOMANDLOVÁ (203 Česká republika, domácí), Jan KUČERA (203 Česká republika, domácí), Jana KUČEROVÁ (203 Česká republika, domácí) a Julie DOBROVOLNÁ (203 Česká republika, domácí)
Vydání
Frontiers in Psychiatry, LAUSANNE, FRONTIERS MEDIA SA, 2022, 1664-0640
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30215 Psychiatry
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 4.700
Kód RIV
RIV/00216224:14110/22:00126850
Organizační jednotka
Lékařská fakulta
UT WoS
000841615400001
Klíčová slova anglicky
osteocalcin; major depressive disorder; biomarker; depression; antidepressant treatment
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 12. 1. 2023 08:11, Mgr. Tereza Miškechová
Anotace
V originále
ObjectivesOsteocalcin is a protein secreted by osteoblasts with a versatile endocrine role. Several domains in which it plays a role-stress response, monoamine synthesis, and cognitive functioning-are implicated also in the pathophysiology of major depressive disorder. In search of possible objective biomarkers of depression, the aim of the study was to assess the relationship between osteocalcin and depressive symptoms during the treatment of depressive episode. MethodsThe study included female inpatients with at least moderate depressive episode. In these patients, depression severity was measured using the Montgomery-angstrom sberg Depression Rating Scale (MADRS), and osteocalcin levels were assessed before the stabilization of antidepressive treatment and after 6 weeks. Relationships between osteocalcin levels and symptoms were analyzed with mixed-effect and linear models, taking into account age, menopausal status, and body mass index. ResultsIn 11 out of 13 enrolled inpatients, osteocalcin levels decreased during the first 6 weeks of treatment; this decrease was significant according to the mixed-effects model (t = -2.345, p = 0.019). According to the linear model, this decrease was significantly associated with reduction in depressive symptom severity (t = 2.673, p = 0.028). Osteocalcin was not associated with initial depressive symptom severity, and initial osteocalcin levels did not predict response to treatment. Limitations of the study include low sample size and inclusion of both pre- and postmenopausal women of various ages. ConclusionsThis preliminary study suggests that osteocalcin may be a candidate biomarker of antidepressive treatment response and that this topic warrants further investigation.
Návaznosti
EF15_003/0000469, projekt VaV |
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EF17_043/0009632, projekt VaV |
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LM2018121, projekt VaV |
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857560, interní kód MU (Kód CEP: EF17_043/0009632) |
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